Gut Microbes,
Journal Year:
2020,
Volume and Issue:
12(1), P. 1802866 - 1802866
Published: Aug. 23, 2020
Over
the
last
two
decades
our
understanding
of
gut
microbiota
and
its
contribution
to
health
disease
has
been
transformed.
Among
a
new
'generation'
potentially
beneficial
microbes
have
recognized
are
members
genus
Eubacterium,
who
form
part
core
human
microbiome.
The
consists
phylogenetically,
quite
frequently
phenotypically,
diverse
species,
making
Eubacterium
taxonomically
unique
challenging
genus.
Several
produce
butyrate,
which
plays
critical
role
in
energy
homeostasis,
colonic
motility,
immunomodulation
suppression
inflammation
gut.
spp.
also
carry
out
bile
acid
cholesterol
transformations
gut,
thereby
contributing
their
homeostasis.
Gut
dysbiosis
consequently
modified
representation
linked
with
various
states.
This
review
provides
an
overview
species
from
phylogenetic
perspective,
describes
how
they
alter
diet
age
summarizes
association
conditions.
Gut,
Journal Year:
2022,
Volume and Issue:
71(5), P. 1020 - 1032
Published: Feb. 1, 2022
The
gut
microbiota
is
now
considered
as
one
of
the
key
elements
contributing
to
regulation
host
health.
Virtually
all
our
body
sites
are
colonised
by
microbes
suggesting
different
types
crosstalk
with
organs.
Because
development
molecular
tools
and
techniques
(ie,
metagenomic,
metabolomic,
lipidomic,
metatranscriptomic),
complex
interactions
occurring
between
microorganisms
progressively
being
deciphered.
Nowadays,
deviations
linked
many
diseases
including
obesity,
type
2
diabetes,
hepatic
steatosis,
intestinal
bowel
(IBDs)
several
cancer.
Thus,
that
various
pathways
involved
in
immunity,
energy,
lipid
glucose
metabolism
affected.
In
this
review,
specific
attention
given
provide
a
critical
evaluation
current
understanding
field.
Numerous
mechanisms
explaining
how
bacteria
might
be
causally
protection
or
onset
discussed.
We
examine
well-established
metabolites
short-chain
fatty
acids,
bile
trimethylamine
N-oxide)
extend
more
recently
identified
actors
endocannabinoids,
bioactive
lipids,
phenolic-derived
compounds,
advanced
glycation
end
products
enterosynes)
their
receptors
such
peroxisome
proliferator-activated
receptor
alpha
(PPARα)
gamma
(PPARγ),
aryl
hydrocarbon
(AhR),
G
protein-coupled
GPR41,
GPR43,
GPR119,
Takeda
5).
Altogether,
complexity
aspects
linking
health
will
help
set
basis
for
novel
therapies
already
developed.
Journal of Hepatology,
Journal Year:
2019,
Volume and Issue:
72(3), P. 558 - 577
Published: Oct. 15, 2019
The
gut-liver
axis
refers
to
the
bidirectional
relationship
between
gut
and
its
microbiota,
liver,
resulting
from
integration
of
signals
generated
by
dietary,
genetic
environmental
factors.
This
reciprocal
interaction
is
established
portal
vein
which
enables
transport
gut-derived
products
directly
liver
feedback
route
bile
antibody
secretion
intestine.
intestinal
mucosal
vascular
barrier
functional
anatomical
structure
that
serves
as
a
playground
for
interactions
limiting
systemic
dissemination
microbes
toxins
while
allowing
nutrients
access
circulation
reach
liver.
control
microbial
communities
critical
maintaining
homeostasis
axis,
part
this
communication
shapes
communities.
Alcohol
disrupts
at
multiple
interconnected
levels,
including
microbiome,
mucus
barrier,
epithelial
level
antimicrobial
peptide
production,
increases
exposure
proinflammatory
environment
Growing
evidence
indicates
pathogenetic
role
microbe-derived
metabolites,
such
trimethylamine,
secondary
acids,
short-chain
fatty
acids
ethanol,
in
pathogenesis
non-alcoholic
disease.
Cirrhosis
itself
associated
with
profound
alterations
microbiota
damage
different
levels
defence
epithelial,
immune
barriers.
relevance
severe
disturbance
cirrhosis
has
been
linked
translocation
live
bacteria,
bacterial
infections
disease
progression.
identification
elements
primarily
damaged
each
chronic
offers
possibilities
intervention.
Beyond
antibiotics,
upcoming
therapies
centred
on
include
new
generations
probiotics,
metabolites
(postbiotics),
faecal
transplantation,
carbon
nanoparticles.
FXR-agonists
target
both
are
currently
being
tested
diseases.
Finally,
synthetic
biotic
medicines,
phages
specific
bacteria
or
create
physical
barriers
offer
therapeutic
approaches.
Reviews in Endocrine and Metabolic Disorders,
Journal Year:
2019,
Volume and Issue:
20(4), P. 461 - 472
Published: Nov. 9, 2019
Abstract
The
gut
microbiota
is
a
central
regulator
of
host
metabolism.
composition
and
function
the
dynamic
affected
by
diet
properties
such
as
amount
lipids.
Hence,
dietary
lipids
may
influence
physiology
through
interaction
with
microbiota.
Lipids
affect
both
substrates
for
bacterial
metabolic
processes,
inhibiting
growth
toxic
influence.
has
been
shown
to
lipid
metabolism
levels
in
blood
tissues,
mice
humans.
Furthermore,
diseases
linked
dyslipidemia,
non-alcoholic
liver
disease
atherosclerosis,
are
associated
changes
profile.
on
be
mediated
metabolites
produced
short-chain
fatty
acids,
secondary
bile
acids
trimethylamine
pro-inflammatory
bacterially
derived
factors
lipopolysaccharide.
Here
we
will
review
association
between
microbiota,
