Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(10), P. 625 - 637

Published: May 31, 2022

Language: Английский

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Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Cells, Journal Year: 2023, Volume and Issue: 12(1), P. 184 - 184

Published: Jan. 2, 2023

Immune cells and commensal microbes in the human intestine constantly communicate with react to each other a stable environment order maintain healthy immune activities. system-microbiota cross-talk relies on complex network of pathways that sustain balance between tolerance immunogenicity. Probiotic bacteria can interact stimulate intestinal microflora modulate specific functions homeostasis. Growing evidence shows probiotic present important health-promoting immunomodulatory properties. Thus, use probiotics might represent promising approach for improving system So far, few studies have been reported beneficial modulatory effect probiotics. However, many others, which are mainly focused their metabolic/nutritional properties, published. Therefore, mechanisms behind interaction host only partially described. The review aims collect summarize most recent scientific results resulting implications how improve functions. Hence, description currently known is provided.

Language: Английский

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Gut-liver axis: Pathophysiological concepts and clinical implications

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(11), P. 1700 - 1718

Published: Oct. 7, 2022

Language: Английский

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

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TTD: Therapeutic Target Database describing target druggability information

Nucleic Acids Research, Journal Year: 2023, Volume and Issue: 52(D1), P. D1465 - D1477

Published: Sept. 15, 2023

Target discovery is one of the essential steps in modern drug development, and identification promising targets fundamental for developing first-in-class drug. A variety methods have emerged target assessment based on druggability analysis, which refers to likelihood a being effectively modulated by drug-like agents. In therapeutic database (TTD), nine categories established characteristics were thus collected 426 successful, 1014 clinical trial, 212 preclinical/patented, 1479 literature-reported via systematic review. These characteristic classified into three distinct perspectives: molecular interaction/regulation, human system profile cell-based expression variation. With rapid progression technology concerted effort discovery, TTD other databases highly expected facilitate explorations validation innovative target. now freely accessible at: https://idrblab.org/ttd/.

Language: Английский

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Emerging issues in probiotic safety: 2023 perspectives

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 15, 2023

Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical proven adverse events from probiotic consumption exist. New strains products, as well expanding use of probiotics into vulnerable populations, warrants concise, actionable recommendations on how to work toward their safe effective use. The International Scientific Association Prebiotics convened a meeting discuss produce evidence-based potential acute long-term risks, risks the importance product quality match needs need event reporting related whole genome sequencing, which enables determination virulence, toxin, antibiotic resistance genes, clear assignment species strain identity, is emphasized. We present guide scientific medical community judging safety.

Language: Английский

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Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(6), P. 943 - 960.e9

Published: May 15, 2023

Language: Английский

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The gut microbiota in obesity and weight management: microbes as friends or foe?

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(5), P. 258 - 271

Published: Jan. 17, 2023

Language: Английский

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Rethinking healthy eating in light of the gut microbiome

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(6), P. 764 - 785

Published: June 1, 2022

Language: Английский

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The neurobiology of irritable bowel syndrome

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(4), P. 1451 - 1465

Published: Feb. 2, 2023

Abstract Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that affects between 5 and 10% general population worldwide. The current symptom criteria restrict diagnosis to recurrent abdominal pain associated with altered habits, but majority patients also report non-painful discomfort, psychiatric conditions (anxiety depression), as well other visceral somatic pain-related symptoms. For decades, IBS was considered an intestinal motility disorder, more recently a gut disorder. However, based on extensive body reported information about central, peripheral mechanisms genetic factors involved in pathophysiology symptoms, comprehensive disease model brain-gut-microbiome has emerged, which can explain chronic pain, comorbidities. In this review, we will first describe novel insights into several key components microbiome interactions, starting alterations connectome enteric nervous system, list distinct functional structural brain signatures, comparing them proposed anxiety disorders. We then point out emerging correlations networks genomic, gastrointestinal, immune, microbiome-related parameters. incorporate new systems-based IBS. Finally, discuss implications such for improved understanding development effective treatment approaches future.

Language: Английский

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