Metabolic heterogeneity in cancer DOI
Margherita Demicco, Xiao‐Zheng Liu, Katharina Leithner

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 18 - 38

Published: Jan. 24, 2024

Language: Английский

Oxidative Stress in Cancer DOI Creative Commons
John D. Hayes, Albena T. Dinkova‐Kostova, Kenneth D. Tew

et al.

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(2), P. 167 - 197

Published: July 9, 2020

Language: Английский

Citations

1832
Cancer metabolism: looking forward DOI
Inmaculada Martínez‐Reyes, Navdeep S. Chandel

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(10), P. 669 - 680

Published: July 16, 2021

Language: Английский

Citations

1223
The role of ROS in tumour development and progression DOI
Eric C. Cheung, Karen H. Vousden

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(5), P. 280 - 297

Published: Jan. 31, 2022

Language: Английский

Citations

980
The hallmarks of cancer metabolism: Still emerging DOI Creative Commons
Natalya N. Pavlova, Jiajun Zhu, Craig B. Thompson

et al.

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(3), P. 355 - 377

Published: Feb. 4, 2022

Language: Английский

Citations

790
The metabolism of cancer cells during metastasis DOI
Gabriele Bergers, Sarah‐Maria Fendt

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(3), P. 162 - 180

Published: Jan. 18, 2021

Language: Английский

Citations

669
The Complex Interplay between Antioxidants and ROS in Cancer DOI
Isaac S. Harris, Gina M. DeNicola

Trends in Cell Biology, Journal Year: 2020, Volume and Issue: 30(6), P. 440 - 451

Published: April 14, 2020

Language: Английский

Citations

492
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments DOI Creative Commons
Zhennan Yuan, Yingpu Li, Sifan Zhang

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 11, 2023

The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation distant metastasis. Anticancer treatments including adjuvant therapies targeted are effective in eliminating cancer cells but limited number of patients. Increasing evidence suggests that the extracellular matrix (ECM) plays an important role development through changes macromolecule components, degradation enzymes stiffness. These variations under control cellular components tissue via aberrant activation signaling pathways, interaction ECM to multiple surface receptors, mechanical impact. Additionally, shaped regulates immune which results suppressive microenvironment hinders efficacy immunotherapies. Thus, acts as barrier protect from supports progression. Nevertheless, profound regulatory network remodeling hampers design individualized antitumor treatment. Here, we elaborate on composition ECM, discuss specific mechanisms remodeling. Precisely, highlight impact development, proliferation, anoikis, metastasis, angiogenesis, lymphangiogenesis, escape. Finally, emphasize "normalization" potential strategy for anti-malignant

Language: Английский

Citations

368
Metastasis DOI Creative Commons

Stefanie Gerstberger,

Qingwen Jiang, Karuna Ganesh

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

Citations

357
Lipids in the tumor microenvironment: From cancer progression to treatment DOI
Kevin C. Corn,

McKenzie A. Windham,

Marjan Rafat

et al.

Progress in Lipid Research, Journal Year: 2020, Volume and Issue: 80, P. 101055 - 101055

Published: Aug. 11, 2020

Language: Английский

Citations

295
Crosstalk between mechanotransduction and metabolism DOI
Patrizia Romani, Lorea Valcárcel-Jiménez, Christian Frezza

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 22 - 38

Published: Nov. 13, 2020

Language: Английский

Citations

295