Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments

Developmental Cell, Journal Year: 2020, Volume and Issue: 54(2), P. 183 - 195

Published: July 1, 2020

Language: Английский

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Cancer cell plasticity during tumor progression, metastasis and response to therapy

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(8), P. 1063 - 1082

Published: Aug. 3, 2023

Language: Английский

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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Feb. 22, 2021

Abstract Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes non-alcoholic fatty liver disease. Currently, our understanding of metabolic mechanistic implications for immune cells, such as monocytes macrophages, exposed to elevated levels dietary fructose limited. Here, we show that reprograms cellular pathways favour glutaminolysis oxidative metabolism, which are required support inflammatory cytokine production in both LPS-treated human mouse macrophages. A fructose-dependent increase mTORC1 activity drives translation pro-inflammatory cytokines response LPS. LPS-stimulated treated rely heavily on metabolism have reduced flexibility glycolytic mitochondrial inhibition, suggesting glycolysis inextricably coupled these cells. The physiological exposure demonstrated a model LPS-induced systemic inflammation, mice having circulating IL-1β after LPS challenge. Taken together, work underpins role mononuclear phagocytes occurs at expense flexibility.

Language: Английский

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The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: April 22, 2022

Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive oxygen species (ROS) exert paradoxical effects cancers; an appropriate concentration stimulates tumorigenesis and supports progression cells, while excessive leads to cell death. The upregulated antioxidant system in cells limits ROS tumor-promoting level. In cancers, redox regulation interacts with tumor initiation, proliferation, metastasis, programmed death, autophagy, metabolic reprogramming, microenvironment, therapies, therapeutic resistance facilitate development. This review discusses control major hallmarks cancer.

Language: Английский

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Metabolic heterogeneity in cancer

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 18 - 38

Published: Jan. 24, 2024

Language: Английский

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