Interaction between redox regulation, immune activation, and response to treatment in HER2+ breast cancer DOI Creative Commons
Paulo Luz, Sofı́a Ramos, Maria José Oliveira

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103609 - 103609

Published: March 1, 2025

In HER2+ breast cancer (BC), neoadjuvant therapy represents an ideal scenario for translational research, considering pathological complete response (pCR) as endpoint. these patients, achieving pCR after is associated with a better prognosis. However, biomarkers are needed to tailor optimal treatment each patient. Evaluating tumour-infiltrating lymphocytes (TILs) has gained attention in predicting pCR. the context of metastatic disease, TILs also appear play role outcomes. The interaction between presence and reactive oxygen species (ROS) remains area be explored. ROS critical tumour cell homeostasis, different levels can trigger differential biological responses cells their microenvironment. Nevertheless, influence on efficacy prognosis patients BC elucidated. this article, we reviewed interplay response, immune system activation, production suggested novel areas intervention research. We present bioinformatic analysis demonstrating that altered expression several redox-related genes could prevalence populations microenvironment patient survival. New thus should further explored best

Language: Английский

Interplay of oxidative stress, cellular communication and signaling pathways in cancer DOI Creative Commons
Muhammad Javed Iqbal,

Ayesha Kabeer,

Zaighum Abbas

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 2, 2024

Abstract Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays critical role in development cancer affecting genomic stability signaling pathways cellular microenvironment. Elevated levels ROS disrupt homeostasis contribute to loss normal functions, which are associated initiation progression various types cancer. In this review, we have focused on elucidating downstream that influenced oxidative stress carcinogenesis. These include p53, Keap1-NRF2, RB1, p21, APC, tumor suppressor genes, cell type transitions. Dysregulation these can lead uncontrolled growth, impaired DNA repair mechanisms, evasion death, all hallmark features development. Therapeutic strategies aimed at targeting emerged as area investigation for molecular biologists. The objective is limit response time cancer, including liver, breast, prostate, ovarian, lung cancers. By modulating redox balance restoring homeostasis, it may be possible mitigate damaging effects enhance efficacy treatments. targeted therapies interventions specifically address impact holds great promise improving patient outcomes. approaches antioxidant-based treatments, redox-modulating agents, restore function affected stress. summary, understanding carcinogenesis process through therapeutic utmost importance combating Further research needed unravel complex mechanisms underlying stress-related develop effective translated into clinical applications management treatment

Language: Английский

Citations

123
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis DOI
Hardeep Singh Tuli, Jagjit Kaur,

Kanupriya Vashishth

et al.

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 97(1), P. 103 - 120

Published: Nov. 28, 2022

Language: Английский

Citations

57
Remodeling tumor microenvironment with natural products to overcome drug resistance DOI Creative Commons
Wanlu Zhang, Shubo Li, Chunting Li

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand find safer more effective anticancer strategy for patients. Natural products, have the advantage low toxicity multiple action targets, are always used treatment prevention early stage supplement late stage. Tumor microenvironment necessary cells survive progression, immune activation vital means tumor eliminate cells. A number studies found that various natural products could target regulate such as T cells, macrophages, mast well inflammatory cytokines microenvironment. tuning via mechanisms activate response immeasurable potential immunotherapy. In this review, it highlights research findings related regulating responses against cancer, especially reveals possibility utilizing remodel overcome resistance.

Language: Английский

Citations

40
ROS are evolutionary conserved cell-to-cell stress signals DOI Creative Commons
Yosef Fichman, Linda Rowland, Melvin J. Oliver

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(31)

Published: July 26, 2023

Cell-to-cell communication is fundamental to multicellular organisms and unicellular living in a microbiome. It thought have evolved as stress- or quorum-sensing mechanism organisms. A unique cell-to-cell that uses reactive oxygen species (ROS) signal (termed the “ROS wave”) was identified flowering plants. This process essential for systemic signaling plant acclimation stress can spread from small group of cells entire within minutes. Whether similar found other however unknown. Here, we report ROS wave be algae, amoeba, ferns, mosses, mammalian cells, isolated hearts. We further show this triggered by local H 2 O treatment blocked application catalase NADPH oxidase inhibitors algae it communicates important stress–response signals between cells. Taken together, our findings suggest an active signaling, like wave, before diverged. could communicated environmental coordinated response many different community. The finding process, contributes understanding diseases impact development drugs target example cancer heart disease.

Language: Английский

Citations

34
The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy DOI Creative Commons
Elena Puris, Gert Fricker, Mikko Gynther

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 364 - 364

Published: Jan. 21, 2023

Transporter-mediated drug resistance is a major obstacle in anticancer delivery and key reason for cancer therapy failure. Membrane solute carrier (SLC) transporters play crucial role the cellular uptake of drugs. The expression function SLC can be down-regulated cells, which limits drugs into tumor resulting inefficiency therapy. In this review, we summarize current understanding low-SLC-transporter-expression-mediated different types cancers. Recent advances SLC-transporter-targeting strategies include development transporter-utilizing prodrugs nanocarriers modulation transporter cells. These will an important future therapies by enabling efficient

Language: Английский

Citations

30
Nanoparticles (NPs)-mediated targeted regulation of redox homeostasis for effective cancer therapy DOI Creative Commons
Zixuan Zhao,

Yuan Cao,

Rui Xu

et al.

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 291 - 320

Published: March 24, 2024

Language: Английский

Citations

9
Plasma–liquid interactions in the presence of organic matter—A perspective DOI
Katharina Stapelmann, Sophia Gershman, Vandana Miller

et al.

Journal of Applied Physics, Journal Year: 2024, Volume and Issue: 135(16)

Published: April 26, 2024

As investigations in the biomedical applications of plasma advance, a demand for describing safe and efficacious delivery is emerging. It quite clear that not all plasmas are "equal" applications. This Perspective discusses limitations existing parameters used to define context need "right plasma" at dose" each "disease system." The validity results extrapolated from

Language: Английский

Citations

8
Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies DOI
Ismail Eş, Aneesh Thakur, Amin Mousavi Khaneghah

et al.

Biotechnology Advances, Journal Year: 2024, Volume and Issue: 72, P. 108342 - 108342

Published: March 20, 2024

Language: Английский

Citations

7
Glutathione-Dependent Pathways in Cancer Cells DOI Open Access
Elena Kalinina

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8423 - 8423

Published: Aug. 1, 2024

The most abundant tripeptide—glutathione (GSH)—and the major GSH-related enzymes—glutathione peroxidases (GPxs) and glutathione S-transferases (GSTs)—are highly significant in regulation of tumor cell viability, initiation development, its progression, drug resistance. high level GSH synthesis different cancer types depends not only on increasing expression key enzymes γ-glutamyl cycle but also changes transport velocity precursor amino acids. ability GPxs to reduce hydroperoxides is used for cellular each member GPx family has a mechanism action site maintaining redox balance. GSTs catalyze conjugation electrophilic substances reduction organic take part signaling pathways. By catalyzing S-glutathionylation target proteins, are involved processes, including metabolism (e.g., glycolysis PPP), signal transduction, transcription regulation, development resistance anticancer drugs. In this review, recent findings synthesis, roles functions GPxs, GST isoforms discussed, along with search inhibitors treatment.

Language: Английский

Citations

6
Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors DOI Creative Commons
Fiona C. Malcomson, John C. Mathers

Redox Biology, Journal Year: 2023, Volume and Issue: 62, P. 102710 - 102710

Published: April 23, 2023

Personalised and precision nutrition uses information on individual characteristics responses to nutrients, foods dietary patterns develop targeted nutritional advice that is more effective in improving the diet health of each individual. Moving away from conventional 'one size fits all', such intervention approaches may pave way better population health, including lower burden non-communicable diseases. To date, most personalised have been focussed tackling obesity cardiometabolic diseases with limited efforts directed cancer prevention for survivors. Advances understanding biological basis role played by survival after diagnosis, mean it timely test apply area. This endeavour can take advantage enhanced interactions between factors, genotype gut microbiome impact risk of, after, diagnosis. Translation these basic research into public action should include real-time acquisition nutrigenomic related data use AI-based integration methods systems be scaled up using mobile devices.

Language: Английский

Citations

14