Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies DOI Open Access
Pilar Codoñer‐Franch, Marie Gombert, José Martı́nez-Raga

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7579 - 7579

Published: April 20, 2023

Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired rhythms are associated with mental disorders. The evening chronotype, which misalignment, risk factor for severe psychiatric symptoms metabolic comorbidities. Resynchronization of commonly improves symptoms. Furthermore, evidence indicates that preventing misalignment help reduce disorders impact neuro–immuno–metabolic disturbances in psychiatry. gut microbiota exhibits diurnal rhythmicity, as governed by meal timing, regulates host’s rhythms. Temporal regulation feeding has emerged promising chronotherapeutic strategy prevent and/or treatment illnesses, through modulation microbiota. Here, we provide an overview link between disruption illness. We summarize connection rhythms, supporting idea aid resynchronization disrupted describe microbiome rhythmicity its related factors, highlighting role timing. Lastly, emphasize necessity rationale further research develop effective safe dietary strategies based chrononutrition combat

Language: Английский

Hallmarks of Health DOI Creative Commons
Carlos López‐Otín, Guido Kroemer

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 33 - 63

Published: Dec. 18, 2020

Language: Английский

Citations

377
Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer DOI
Faraz Bishehsari, Robin M. Voigt, Ali Keshavarzian

et al.

Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(12), P. 731 - 739

Published: Oct. 26, 2020

Language: Английский

Citations

243
The Microbiota–Gut–Brain Axis in Psychiatric Disorders DOI Open Access
Aleksandra Góralczyk-Bińkowska, Dagmara Szmajda‐Krygier, Elżbieta Kozłowska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11245 - 11245

Published: Sept. 24, 2022

Modulating the gut microbiome and its influence on human health is subject of intense research. The microbiota could be associated not only with gastroenterological diseases but also psychiatric disorders. importance factors such as stress, mode delivery, role probiotics, circadian clock system, diet, occupational environmental exposure in relationship between brain function through bidirectional communication, described "the microbiome-gut-brain axis", especially underlined. In this review, we discuss link intestinal host response involving different pathways nervous system (e.g., neurotransmitters, endocrine immunological mechanisms, or bacterial metabolites). We review alterations their results development disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar (BD), autism spectrum (ASD), attention-deficit hyperactivity (ADHD).

Language: Английский

Citations

237
Cycles in epilepsy DOI
Philippa J. Karoly, Vikram R. Rao, Nicholas M. Gregg

et al.

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 17(5), P. 267 - 284

Published: March 15, 2021

Language: Английский

Citations

206
Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review DOI
Yunzhen Zhang,

Lezhen Dong,

Lingyi Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(21), P. 6300 - 6316

Published: May 17, 2022

Hydrogels obtained from natural polymers have received widespread attention for their excellent biocompatible property, nontoxicity, easy gelation, and functionalization. Polysaccharides can regulate the gut microbiota improve intestinal microenvironment, thus exerting healthy effect of immunity. In an active substance delivery system, extent speed reaching its target are highly dependent on carrier. Thus, smart systems gradually increasing. The polysaccharide-hydrogels possess ability in response to external stimuli through changing volume phase structure, which applied various fields. Natural polysaccharide-based hydrogels characteristics environmental friendliness, good biocompatibility, abundant sources. According type, usually divided into stimulus-responsive hydrogels, including internal (pH, temperature, enzyme, redox) (light, electricity, magnetism) hydrogels. system based polysaccharides exert effects gastrointestinal tract. At same time, may also take part regulating brain signals microbiota-gut-brain axis. Therefore, considered as promising biomaterials, be designed gut-brain This article reviews research advance focus types, characteristics, applications systems.

Language: Английский

Citations

123
Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease DOI Creative Commons
Simon Spichak, Thomaz F. S. Bastiaanssen,

Kirsten Berding

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 125, P. 698 - 761

Published: March 5, 2021

There is increasing knowledge regarding the role of microbiome in modulating brain and behaviour. Indeed, actions microbial metabolites are key for appropriate gut-brain communication humans. Among these metabolites, short-chain fatty acids, tryptophan, bile acid metabolites/pathways show strong preclinical evidence involvement various aspects function With identification neuroactive modules, new predictive tools can be applied to existing datasets. We identified 278 studies relating human microbiota-gut-brain axis which included sequencing data. This spanned across psychiatric neurological disorders with a small number also focused on normal behavioural development. consistent bioinformatics pipeline, thirty-five datasets were reanalysed from publicly available raw files remainder summarised collated. studies, we uncovered disease-related alterations metabolic pathways Alzheimer's Disease, schizophrenia, anxiety depression. Amongst that could not reanalysed, many technical limitations hindered discovery specific biomarkers microbes or conserved studies. Future warranted confirm our findings. propose guidelines future analysis increase reproducibility consistency within field.

Language: Английский

Citations

107
Microbiota and sleep: awakening the gut feeling DOI
Paromita Sen,

Alicia Molinero-Perez,

Kenneth J. O’Riordan

et al.

Trends in Molecular Medicine, Journal Year: 2021, Volume and Issue: 27(10), P. 935 - 945

Published: Aug. 4, 2021

Language: Английский

Citations

105
Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota DOI Creative Commons
Teng Ma, Hao Jin, Lai‐Yu Kwok

et al.

Neurobiology of Stress, Journal Year: 2021, Volume and Issue: 14, P. 100294 - 100294

Published: Jan. 14, 2021

Stress has been shown to disturb the balance of human intestinal microbiota and subsequently causes mental health problems like anxiety depression. Our previous study showed that ingesting probiotic strain, Lactobacillus (L.) plantarum P-8, for 12 weeks could alleviate stress stressed adults. The current was a follow-up work aiming investigate functional role gut metagenomes in observed beneficial effects. fecal (n = 43) placebo 36) receivers were analyzed depth. microbiomes group at 0 significantly greater Aitchison distance (P < 0.001) compared with group. Meanwhile, Shannon diversity index 0.05) but not decreased week 12. Additionally, more species-level genome bins (SGBs) Bifidobacterium adolescentis, longum, Fecalibacterium prausnitzii 0.01) identified group, while abundances SGBs representing species Roseburia faecis Fusicatenibacter saccharivorans 0.05). Furthermore, 12-week supplementation enhanced neurotransmitter-synthesizing/consuming levels some predicted microbial neuroactive metabolites (e.g., short-chain fatty acids, gamma-aminobutyric acid, arachidonic sphingomyelin). results potential link between probiotic-induced modulation stress/anxiety alleviation adults, supporting gut-brain axis involved relieving stress-related symptoms. effect relied only on changes importantly metagenome modulations SGB gene levels.

Language: Английский

Citations

104
Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism DOI Creative Commons
Ruizhe Zhu, Yilin Fang, Hongyu Li

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Test anxiety is a common issue among college students, which can affect their physical and psychological health. However, effective interventions or therapeutic strategies are still lacking. This study aims to evaluate the potential effects of

Language: Английский

Citations

84
Gut microbiota: A new target of traditional Chinese medicine for insomnia DOI Open Access

Wanying Feng,

Zhihua Yang,

Yangxi Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114344 - 114344

Published: Feb. 2, 2023

All species have a physiological need for sleep, and sleep is crucial the preservation restoration of many processes in body. Recent research on effects gut microbiota brain function has produced essential data relationship between them. It been discovered that dysregulation gut-brain axis related to insomnia. Certain metabolites linked insomnia, disturbances can worsen Traditional Chinese medicine (TCM) unique advantages treatment Taking as target determining scientific relevance TCM prevention insomnia may lead new concepts disorders improve therapeutic effect sleep. an entry point, this paper reviews TCM, mechanism by which regulate regulates treatment. This review provides ideas through drug development.

Language: Английский

Citations

43