Bifidobacterium Longum: Protection against Inflammatory Bowel Disease

Journal of Immunology Research, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 11

Published: July 23, 2021

The prevalence of inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s (CD), increases gradually worldwide in the past decades. IBD is generally associated with change immune system gut microbiota, conventional treatments usually result some side effects. Bifidobacterium longum, as colonizing bacteria intestine, has been demonstrated to be capable relieving mice can employed an alternative or auxiliary way for treating IBD. Here, mechanisms longum treatment were summarized based on previous cell animal studies clinical trials testing bacterial therapies. This review will served a basis future research treatment.

Language: Английский

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Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 178 - 198

Published: June 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Language: Английский

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Micro/nano-plastics cause neurobehavioral toxicity in discus fish (Symphysodon aequifasciatus): Insight from brain-gut-microbiota axis

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 421, P. 126830 - 126830

Published: Aug. 5, 2021

Language: Английский

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The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3258 - 3258

Published: July 23, 2023

The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention treatment strategies for disorders. Several gut microbiota, especially Firmicutes Bacteroidetes, are demonstrated affect health through microbiota-gut-brain axis, the microbiota dysbiosis can be related disorders, such as anxiety, depression, other On hand, dietary components, including probiotics Lactobacillus Bifidobacterium), prebiotics fiber alpha-lactalbumin), synbiotics, postbiotics short-chain fatty acids), dairy products, spices Zanthoxylum bungeanum, curcumin, capsaicin), fruits, vegetables, medicinal herbs, so on, could exert protective effects against by enhancing beneficial while suppressing harmful ones. In this paper, disorder-associated summarized. addition, components on targeting discussed. This paper helpful develop some natural products into pharmaceuticals functional foods prevent treat

Language: Английский

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Probiotics synergized with conventional regimen in managing Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2022, Volume and Issue: 8(1)

Published: May 24, 2022

Parkinson's disease (PD) is mainly managed by pharmacological therapy (e.g., Benserazide and dopamine agonists). However, prolonged use of these drugs would gradually diminish their dopaminergic effect. Gut dysbiosis was observed in some patients with PD, suggesting close association between the gut microbiome PD. Probiotics modulate host's microbiota beneficially. A 3-month randomized, double-blind, placebo-controlled clinical trial conducted to investigate beneficial effect probiotic co-administration Eighty-two PD were recruited randomly divided into [n = 48; Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8), Benserazide, agonists] placebo (n 34; placebo, agonists) groups. Finally, 45 29 from groups provided complete fecal serum samples for further omics analysis, respectively. The results showed that conferred added benefits improving sleep quality, alleviating anxiety, gastrointestinal symptoms. Metagenomic analysis that, after intervention, there significantly more species-level genome bins (SGBs) animalis, Ruminococcaceae, Lachnospira, while less Lactobacillus fermentum Klebsiella oxytoca group (P < 0.05). Interestingly, correlated positively scores UPDRS-III, HAMA, HAMD-17, negatively MMSE. feces hardness. Moreover, co-administering increased SGBs involved tryptophan degradation, gamma-aminobutyric acid, short-chain fatty acids, secondary bile acid biosynthesis, as well acetic levels Taken together, synergized conventional regimen strengthened efficacy managing accompanied modifications microbiome, microbial metabolic potential, metabolites.

Language: Английский

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Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Test anxiety is a common issue among college students, which can affect their physical and psychological health. However, effective interventions or therapeutic strategies are still lacking. This study aims to evaluate the potential effects of

Language: Английский

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The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(20), P. 4491 - 4538

Published: Sept. 27, 2023

The physiological consequences of stress often manifest in the gastrointestinal tract. Traumatic or chronic is associated with widespread maladaptive changes throughout gut, although comparatively little known about effects acute stress. Furthermore, these stress-induced gut may increase susceptibility to disorders and infection, impact critical features neural behavioural response by impairing gut-brain axis communication. Understanding mechanisms behind enteric nervous system circuitry, visceral sensitivity, barrier function, permeability, microbiota following an important research objective pathophysiological implications both neurogastroenterology psychiatry. Moreover, has emerged as a key aspect physiology sensitive In this review, we focus on different aspects tract including function well immune, humoral neuronal elements involved discuss evidence for role disorders. Existing gaps current literature are highlighted, possible avenues future integrated perspective have been suggested. A more complete understanding spatial temporal dynamics host microbial kinds stressors will enable full exploitation diagnostic therapeutic potential fast-evolving field host-microbiome interactions.

Language: Английский

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Gamma-aminobutyric acid as a potential postbiotic mediator in the gut–brain axis

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: April 2, 2024

Abstract Gamma-aminobutyric acid (GABA) plays a crucial role in the central nervous system as an inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with neurological diseases, such Alzheimer’s and Parkinson’s disease, psychological disorders, including anxiety, depression, stress. Since GABA has long been believed to not cross blood–brain barrier, effects circulating on brain neglected. However, emerging evidence demonstrated that changes both levels gut microbiota composition play modulating mental health. This recent research raised possibility may be potent mediator gut–brain axis. review article will cover up-to-date information about GABA-producing microorganisms isolated from human food sources, explanation why those produce GABA, factors inducing gut–GABA production, suggesting linking between health, stress, epilepsy, autism spectrum disorder, attention deficit hyperactivity novel regarding homocarnosine-a predominant peptide is putative downstream regulating functions. help us understand how GABA-homocarnosine metabolism significant Nonetheless, it could support further use production-inducing agents treat disorders.

Language: Английский

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Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3340 - 3340

Published: March 15, 2024

Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies expand boundaries neuropharmacology, studies from field have highlighted gut microbiota’s role modulating these disorders. These alterations may influence brain’s processes through brain–gut axis, multifaceted bidirectional system that establishes connection between enteric central nervous systems. Thus, probiotic prebiotic supplements are meant overall health play an insightful alleviating psychiatric symptoms, such templates major depressive disorder, anxiety, or schizophrenia. Moreover, administration psychotropic drugs has been revealed induce specific changes microbiome’s diversity, suggesting their potential utility combating bacterial infections. This review emphasizes intricate correlations microbiota, mentioning promising approaches regard modulation treatments, well antimicrobial effects medication.

Language: Английский

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Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome

Microbiology Spectrum, Journal Year: 2021, Volume and Issue: 9(2)

Published: Oct. 7, 2021

Asthma is a multifactorial disorder, and microbial dysbiosis enhances lung inflammation asthma-related symptoms. Probiotics have shown anti-inflammatory effects could regulate the gut-lung axis. Thus, 3-month randomized, double-blind, placebo-controlled human trial was performed to investigate adjunctive efficacy of probiotics in managing asthma. Fifty-five asthmatic patients were randomly assigned probiotic group (n = 29; received Bifidobacterium lactis Probio-M8 powder Symbicort Turbuhaler) placebo 26; Turbuhaler), all 55 subjects provided details their clinical history demographic data. However, only 31 donated complete set fecal blood samples at three time points for further analysis. Compared with those group, co-administering Turbuhaler significantly decreased fractional exhaled nitric oxide level day 30 (P 0.049) improved asthma control test score end intervention 0.023). More importantly, alveolar concentration among receivers 0.038), symptom relief effect even more obvious 90 0.001). Probiotic co-administration increased resilience gut microbiome, which reflected by minor fluctuations microbiome diversity > 0.05, receivers; P < receivers). Additionally, showed changes some species-level genome bins (SGBs), namely, increases potentially beneficial species animalis, longum, Prevotella sp. CAG decreases Parabacteroides distasonis Clostridiales bacterium 0.05). that metabolic potential exhibited levels predicted bioactive metabolites (linoleoyl ethanolamide, adrenergic acid, erythronic acid) serum (5-dodecenoic tryptophan, sphingomyelin) during/after intervention. Collectively, our results suggested synergized conventional therapy alleviate diseases associated axis, like asthma, possibly via activating multiple pathways. IMPORTANCE The microbiota has on pathogenesis closely related disease phenotype. Our demonstrated findings present study provide new insights into treatment mechanisms novel therapeutic strategies, application probiotics-based therapy.

Language: Английский

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