The Gut Microbiome and Metabolites Are Altered and Interrelated in Patients With Rheumatoid Arthritis DOI Creative Commons

Die Yu,

Juping Du,

Xia Pu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 11

Published: Jan. 25, 2022

The relationship among the gut microbiome, global fecal metabolites and rheumatoid arthritis (RA) has not been systematically evaluated. In this study, we performed 16S rDNA sequencing liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based nontargeted metabolomic profiling on feces of 26 untreated RA patients healthy controls. Twenty-six genera forty-one MS2-identified were significantly altered in patients. Klebsiella, Escherichia, Eisenbergiella Flavobacterium more abundant patients, while Fusicatenibacter, Megamonas Enterococcus Function prediction analysis demonstrated that biosynthesis pathways amino acids, such as L-arginine aromatic depleted group. metabolome results, including glycerophospholipids (PC(18:3(9Z,12Z,15Z)/16:1(9Z)), lysoPE 19:1, 18:0, lysoPC(18:0/0:0)), sphingolipids (Cer(d18:0/16:0), Cer(d18:0/12:0), Cer(d18:0/14:0)), kynurenic acid, xanthurenic acid 3-hydroxyanthranilic remarkably between Dysregulation pathways, tryptophan metabolism, alpha-linolenic metabolism glycerophospholipid may contribute to development RA. Additionally, revealed microbiome interrelated Escherichia was core genus. By depicting overall landscape intestinal our study could provide possible novel research directions regarding pathogenesis targeted therapy.

Language: Английский

The role of short-chain fatty acids in immunity, inflammation and metabolism DOI
Yao Yao, Xiaoyu Cai, Weidong Fei

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2020, Volume and Issue: 62(1), P. 1 - 12

Published: Dec. 1, 2020

Short-chain fatty acids (SCFAs) are carboxylic with carbon atom numbers less than 6, which important metabolites of gut microbiome. Existing research shows that SCFAs play a vital role in the health and disease host. First, key energy source for colon ileum cells, affect intestinal epithelial barrier defense functions by regulating related gene expression. Second, regulate function innate immune cells to participate system, such as macrophages, neutrophils dendritic cells. Third, can also differentiation T B antigen-specific adaptive immunity mediated them. Besides, raw materials sugar lipid synthesis, provides theoretical basis studying potential homeostasis metabolism. There studies showing inhibit tumor cell proliferation promote apoptosis. In this article, we summarized detail immunity, inflammation metabolism, briefly introduced survival. It systematic study drugs human health.

Language: Английский

Citations

455
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases DOI Open Access
Wenjing Yang, Yingzi Cong

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(4), P. 866 - 877

Published: March 11, 2021

Language: Английский

Citations

333
One year in review 2021: pathogenesis of rheumatoid arthritis DOI Open Access
Davide Testa,

Santina Calvacchi,

Fiorella Petrelli

et al.

Clinical and Experimental Rheumatology, Journal Year: 2021, Volume and Issue: 39(3), P. 445 - 452

Published: May 21, 2021

Language: Английский

Citations

288
The immunology of long COVID DOI Open Access
Daniel M. Altmann, Emily M. Whettlock, Siyi Liu

et al.

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(10), P. 618 - 634

Published: July 11, 2023

Language: Английский

Citations

261
AHR in the intestinal microenvironment: safeguarding barrier function DOI
Brigitta Stockinger, Kathleen Shah, Emma Wincent

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(8), P. 559 - 570

Published: March 19, 2021

Language: Английский

Citations

250
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives DOI Creative Commons
Juan Liu, Yuzhu Tan, Hao Cheng

et al.

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(4), P. 1106 - 1106

Published: Jan. 1, 2022

Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides crucial signaling metabolites for the physiological hosts. In healthy state, gut microbiota are helpful maintaining basic functions hosts, whereas disturbed production these can lead to numerous diseases such as metabolic diseases, cardiovascular neurodegenerative and cancer. Although there many reviews about specific mechanisms on is no comprehensive summarization metabolites. this Opinion, we discuss knowledge including types their ways acting targets. addition, summarize pathologic in health shaping composition nutrition. This paper be understanding roles thus provide guidance developing suitable therapeutic strategies combat microbial-driven improve health.

Language: Английский

Citations

249
Immunosuppressive Mechanisms of Regulatory B Cells DOI Creative Commons
Diego Catalán,

Miguel Andrés Mansilla,

Ashley Ferrier

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: April 29, 2021

Regulatory B cells (Bregs) is a term that encompasses all act to suppress immune responses. Bregs contribute the maintenance of tolerance, limiting ongoing responses and reestablishing homeostasis. The important role in restraining pathology associated with exacerbated inflammatory autoimmunity graft rejection has been consistently demonstrated, while more recent studies have suggested for this population other immune-related conditions, such as infections, allergy, cancer, chronic metabolic diseases. Initial identified IL-10 hallmark Breg function; nevertheless, past decade seen discovery molecules utilized by human murine regulate This new arsenal includes anti-inflammatory cytokines IL-35 TGF-β, well cell surface proteins like CD1d PD-L1. In review, we examine main suppressive mechanisms employed these novel populations. We also discuss evidence helps unravel previously unknown aspects phenotype, development, activation, function IL-10-producing Bregs, incorporating an overview on those questions remain obscure.

Language: Английский

Citations

239
Short-chain fatty acids: linking diet, the microbiome and immunity DOI
Elizabeth R. Mann, Ying Ka Lam, Holm H. Uhlig

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(8), P. 577 - 595

Published: April 2, 2024

Language: Английский

Citations

239
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

Citations

231
Tryptophan Metabolism as a Pharmacological Target DOI Creative Commons

Morgane Modoux,

Nathalie Rolhion, Sridhar Mani

et al.

Trends in Pharmacological Sciences, Journal Year: 2020, Volume and Issue: 42(1), P. 60 - 73

Published: Nov. 27, 2020

L-Tryptophan (L-Trp) is metabolized via three pathways: the indole pathway in bacteria and kynurenine serotonin pathways mammalian cells.Disruptions L-Trp metabolism are reported several diseases making a promising therapeutic target.Manipulating an attractive strategy.Key enzymes of targets inhibitors currently undergoing clinical trials cancerology, dermatology, gastroenterology.Serotonin aryl hydrocarbon receptor (AhR) receptors targeted treatment gastrointestinal diseases, inflammation, many cancers.Next-generation probiotics producing indoles being developed for their ability to activate AhR gut. essential amino acid required protein synthesis. It undergoes extensive complex along pathways, resulting bioactive molecules acting various organs through different action mechanisms. Enzymes involved its metabolism, metabolites themselves, or receptors, represent potential targets, which subject dynamic research. Disruptions L-tryptophan neurological, metabolic, psychiatric, intestinal disorders, paving way develop drugs target it. This review will briefly describe present discuss most recent pharmacological developments targeting

Language: Английский

Citations

223