Infection with SARS-CoV-2 can cause pancreatic impairment DOI Creative Commons
Wei Deng, Linlin Bao, Zhiqi Song

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 12, 2024

Abstract Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction an even higher risk of the occurrence diabetes. Herein, we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates (NHPs) models 121 vaccinated NHPs 2020 to 2023 patients. Multi-label immunofluorescence revealed direct infection both exocrine endocrine cells by virus humans. Minor limited phenotypic histopathological changes were observed adult models. Systemic proteomics metabolomics results indicated metabolic disorders, mainly enriched insulin resistance pathways, NHPs, along with elevated fasting C-peptide C-peptide/glucose ratio levels. Furthermore, elder causes loss beta (β) lower expressed-insulin situ characterized islet amyloidosis necrosis, activation α-SMA aggravated fibrosis consisting collagen serum, increase inflammation stress markers, ICAM-1 G3BP1, more severe dysfunction. In contrast, vaccination maintained glucose homeostasis activating receptor α β. Overall, cumulative diabetes post-COVID-19 is closely tied age, suggesting attention should be paid blood sugar management elderly

Language: Английский

Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021 DOI Creative Commons
Xiaodong Zhou, Qin‐Fen Chen, Wah Yang

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 76, P. 102848 - 102848

Published: Sept. 24, 2024

Language: Английский

Citations

30
Impact of COVID-19 on the Endocrine System: A Mini-review DOI Creative Commons
Sophie Clarke, Ali Abbara, Waljit S. Dhillo

et al.

Endocrinology, Journal Year: 2021, Volume and Issue: 163(1)

Published: Sept. 20, 2021

The coronavirus disease 2019 (COVID-19) pandemic continues to exert a significant impact on global health care systems, causing devastating mortality and morbidity. As time passes our understanding of this novel respiratory virus deepens, it is increasingly clear that its effects extend beyond the system. responsible for COVID-19, severe acute syndrome 2, obtains cellular access through angiotensin-converting enzyme 2 (ACE2) receptor in process requiring transmembrane serine protease (TMPRSS2) protein. Both ACE2 TMPRSS2 are widely expressed many endocrine glands. This, along with several case reports thyroid pituitary disruption patients has resulted interest Indeed, as abated by increasing availability effective vaccines, there focus long-term COVID-19 survivors. This review summarizes data investigating each axes guide appropriate investigations optimal management.

Language: Английский

Citations

100
COVID-19–Induced New-Onset Diabetes: Trends and Technologies DOI Open Access
Ahmed A. Metwally,

Pranav Mehta,

Brian S. Johnson

et al.

Diabetes, Journal Year: 2021, Volume and Issue: 70(12), P. 2733 - 2744

Published: Oct. 22, 2021

The coronavirus disease 2019 (COVID-19) global pandemic continues to spread worldwide with approximately 216 million confirmed cases and 4.49 deaths date. Intensive efforts are ongoing combat this by suppressing viral transmission, understanding its pathogenesis, developing vaccination strategies, identifying effective therapeutic targets. Individuals preexisting diabetes also show higher incidence of COVID-19 illness poorer prognosis upon infection. Likewise, an increased frequency onset complications has been reported in patients following diagnosis. may elevate the risk hyperglycemia other without prior history. It is unclear whether virus induces type 1 or 2 instead causes a novel atypical form diabetes. Moreover, it remains unknown if recovering exhibit new-onset going forward. aim review summarize what currently known about epidemiology mechanisms bidirectional relationship between We highlight major challenges that hinder study COVID-19–induced propose potential framework for overcoming these obstacles. state-of-the-art wearables microsampling technologies can further management progression cases. conclude outlining current research initiatives investigating diabetes, some emphasis on wearable technology.

Language: Английский

Citations

90
Diabetes and COVID-19: The past, the present, and the future DOI Open Access
Raymond Pranata, Joshua Henrina, Wilson Matthew Raffaello

et al.

Metabolism, Journal Year: 2021, Volume and Issue: 121, P. 154814 - 154814

Published: June 11, 2021

Language: Английский

Citations

86
Microbiome Profiling Using Shotgun Metagenomic Sequencing Identified Unique Microorganisms in COVID-19 Patients With Altered Gut Microbiota DOI Creative Commons
Sijia Li, Siyuan Yang, Yuzheng Zhou

et al.

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 11, 2021

COVID-19 is mainly associated with respiratory distress syndrome, but a subset of patients often present gastrointestinal (GI) symptoms. Imbalances gut microbiota have been previously linked to virus infection. Understanding how the gut-lung axis affects progression can provide novel framework for therapies and management. In this study, we examined (n = 47) compared it healthy controls 19). Using shotgun metagenomic sequencing, identified four microorganisms unique in patients, namely Streptococcus thermophilus, Bacteroides oleiciplenus, Fusobacterium ulcerans, Prevotella bivia. The abundances stercoris, B. vulgatus, massiliensis, Bifidobacterium longum, Lachnospiraceae bacterium 5163FAA, bivia, Erysipelotrichaceae 6145, 2244A were enriched whereas Clostridium nexile, salivarius, Coprococcus catus, Eubacterium hallii, Enterobacter aerogenes, Adlercreutzia equolifaciens decreased (p < 0.05). relative abundance butyrate-producing Roseburia inulinivorans evidently depleted while Paraprevotella sp. probiotic thermophilus increased. We further 30 KEGG orthology (KO) modules overrepresented, 7 increasing 23 decreasing modules. Notably, 15 optimal microbial markers using random forest model strong diagnostic potential distinguishing COVID-19. Based on Spearman's correlation, eight species clinical indices. Moreover, increased Bacteroidetes Firmicutes also found across types Our findings suggest that alterations may influence disease severity. classifier, which was cross-regionally verified, provides proof concept set distinguish presence

Language: Английский

Citations

65
OBESITY MAY HAMPER SARS-CoV-2 VACCINE IMMUNOGENICITY DOI Creative Commons
Raul Pellini, Aldo Venuti, Fulvia Pimpinelli

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: Feb. 26, 2021

ABSTRACT Background The first goal of the study was to analyse antibody titre 7 days after second dose BNT162b2 vaccine in a group 248 healthcare workers (HCW). how changes correlation with age, gender and BMI. Methods Participants were assigned receive priming at baseline booster day 21. Blood nasopharyngeal swabs collected vaccine. Findings HWCs analysed, 158 women (63.7%) 90 men (36.3%). After vaccine, 99.5% participants developed humoral immune response. geometric mean concentration antibodies among vaccinated subjects (285.9 AU/mL 95% CI: 249.5-327.7); higher than that human convalescent sera (39.4 AU/mL, 33.1-46.9), p<0.0001. found be young female participants. A strong BMI classes titres noticed: response more efficient under- normal-weight vs pre- obesity (p<0.0001 T1). Interpretation These findings imply females, lean people have an increased capacity mount responses compared males, overweight older population. Although further studies are needed, this data may important implications for development vaccination strategies COVID-19, particularly obese people. Funding None

Language: Английский

Citations

61
Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection DOI Creative Commons

Mahnaz Norouzi,

Shaghayegh Norouzi,

Alistaire D. Ruggiero

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(6), P. 1211 - 1211

Published: June 3, 2021

The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed disease 2019 (COVID-19), has generated a notable challenge for diabetic patients. Overall, people with diabetes have higher risk of developing different infectious diseases and demonstrate increased mortality. Type mellitus (T2DM) is significant factor COVID-19 progression its severity, poor prognosis, How contributes to severity unclear; however, it may be correlated the effects hyperglycemia on systemic inflammatory responses immune system dysfunction. Using envelope spike glycoprotein SARS-CoV-2, binds angiotensin-converting enzyme (ACE2) receptors, key protein expressed in metabolic organs tissues such as pancreatic islets. Therefore, been suggested that patients are more susceptible SARS-CoV-2 infections, glucose metabolism impairments complicate pathophysiology these In this review, we provide insight into complications relevant try focus present data growing concepts surrounding infections T2DM

Language: Английский

Citations

59
Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans DOI Creative Commons

Martin Zickler,

Stephanie Stanelle‐Bertram,

Sandra Ehret

et al.

Cell Metabolism, Journal Year: 2021, Volume and Issue: 34(1), P. 1 - 2

Published: Dec. 10, 2021

Language: Английский

Citations

56
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner DOI Creative Commons
Tatiana D. Saccon, Felippe Mousovich‐Neto, Raissa G. Ludwig

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 29, 2022

Abstract Visceral adiposity is a risk factor for severe COVID-19, and link between adipose tissue infection disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human undergoes productive in fat cells. However, susceptibility to the cellular response depends on anatomical origin of cells viral lineage. express more ACE2 are susceptible than their subcutaneous counterparts. leads inhibition lipolysis cells, while visceral it results higher expression pro-inflammatory cytokines. Viral load attenuated when infected with gamma variant. A similar degree cell death occurs 4-days after infection, regardless or Hence, replicating altering function viability depot- lineage-dependent fashion.

Language: Английский

Citations

52
Limited extent and consequences of pancreatic SARS-CoV-2 infection DOI Creative Commons
Verena van der Heide, Sonia Jangra, Phillip Cohen

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 38(11), P. 110508 - 110508

Published: Feb. 21, 2022

Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of disease 2019 (COVID-19), may cause new-onset diabetes persist in an evolving research landscape, and precise risk assessment is hampered by, at times, conflicting evidence. Here, leveraging comprehensive single-cell analyses vitro SARS-CoV-2-infected human pancreatic islets, we demonstrate productive strictly dependent on SARS-CoV-2 entry receptor ACE2 targets practically all cell types. Importantly, remains highly circumscribed largely non-cytopathic and, despite a high viral burden infected subsets, promotes only modest cellular perturbations inflammatory responses. Similar experimental outcomes are also observed after islet endemic coronaviruses. Thus, limits infection, even under conditions enhanced virus exposure, challenge proposition vivo targeting β cells by precipitates diabetes. Whether restricted damage immunological alterations accrued COVID-19 increase cumulative risk, however, to be evaluated.

Language: Английский

Citations

48