Diabetes and SARS-CoV-2–Is There a Mutual Connection? DOI Creative Commons

Anna P. Jedrzejak,

Edyta Urbaniak,

Jadwiga Waśko

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: June 13, 2022

SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple organs humans, including pancreas. Here, we present bilateral link between pathophysiology of diabetes and COVID-19, with being COVID-19 comorbidity, complication SARS-CoV-2 infection. Analysis clinical data indicates that patients chronic conditions like are at increased risk severe hospitalization, ICU admission, death compared to healthy subjects. Further, show infection might be also associated development new-onset diabetic ketoacidosis. We then discuss options studying pancreatic settings, use human pluripotent stem cell-derived organoids. review presence receptors different cell types efficiency based on sections from primary islet vitro studies. Finally, impact homeostasis, focusing β-cells.

Language: Английский

Risks and burdens of incident diabetes in long COVID: a cohort study DOI
Yan Xie, Ziyad Al‐Aly

The Lancet Diabetes & Endocrinology, Journal Year: 2022, Volume and Issue: 10(5), P. 311 - 321

Published: March 21, 2022

Language: Английский

Citations

468
Two Years into the COVID-19 Pandemic: Lessons Learned DOI Creative Commons
Severino Jefferson Ribeiro da Silva, Jéssica Catarine Frutuoso do Nascimento, Renata Pessôa Germano Mendes

et al.

ACS Infectious Diseases, Journal Year: 2022, Volume and Issue: 8(9), P. 1758 - 1814

Published: Aug. 8, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and virulent human-infecting that emerged in late December 2019 Wuhan, China, causing disease called (COVID-19), which has massively impacted global public health caused widespread disruption to daily life. The crisis by COVID-19 mobilized scientists authorities across the world rapidly improve our knowledge about this devastating disease, shedding light on its management control, spawned development of new countermeasures. Here we provide an overview state art gained last years virus COVID-19, including origin natural reservoir hosts, viral etiology, epidemiology, modes transmission, clinical manifestations, pathophysiology, diagnosis, treatment, prevention, emerging variants, vaccines, highlighting important differences from previously known pathogenic coronaviruses. We also discuss selected key discoveries each topic underline gaps for future investigations.

Language: Английский

Citations

111
Incidence of new-onset in-hospital and persistent diabetes in COVID-19 patients: comparison with influenza DOI Creative Commons
Justin Y. Lu,

Jack Wilson,

Wei Hou

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104487 - 104487

Published: Feb. 28, 2023

Language: Английский

Citations

45
Risk of incident diabetes post-COVID-19: A systematic review and meta-analysis DOI Open Access
Mainak Banerjee, Rimesh Pal, Sulagna Dutta

et al.

Primary care diabetes, Journal Year: 2022, Volume and Issue: 16(4), P. 591 - 593

Published: May 30, 2022

Language: Английский

Citations

55
SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study DOI Open Access
Mikael Knip, Anna Parviainen, Maaret Turtinen

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(4), P. 251 - 260

Published: March 21, 2023

Language: Английский

Citations

31
New-Onset Diabetes After COVID-19 DOI
Sun H. Kim,

Ipsa Arora,

Daniel S. Hsia

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 108(11), P. e1164 - e1174

Published: May 19, 2023

Abstract There is evidence suggesting that infection with SARS-CoV-2 can lead to several long-term sequelae including diabetes. This mini-review examines the rapidly evolving and conflicting literature on new-onset diabetes after COVID-19, which we term NODAC. We searched PubMed, MEDLINE, medRxiv from inception until December 1, 2022, using Medical Subject Headings (MeSH) terms free text words “COVID-19,” “SARS-CoV-2,” “diabetes,” “hyperglycemia,” “insulin resistance,” “pancreatic β-cell.” also supplemented searches by examining reference lists retrieved articles. Current suggests COVID-19 increases risk of developing diabetes, but attributable uncertain because limitations study designs nature pandemic, new variants, widespread population exposure virus, diagnostic options for vaccination status. The etiology likely multifactorial includes factors associated host characteristics (eg, age), social determinants health deprivation index), pandemic-related effects both at personal psychosocial stress) societal-community level containment measures). may have direct indirect pancreatic β-cell function insulin sensitivity related acute its treatment glucocorticoids); autoimmunity; persistent viral residency in multiple organs adipose tissue; endothelial dysfunction; hyperinflammatory state. While our understanding NODAC continues evolve, consideration should be given classified as a post-COVID syndrome, addition traditional classifications type 1 or 2), so pathophysiology, natural history, optimal management studied.

Language: Английский

Citations

27
Generation of functional thymic organoids from human pluripotent stem cells DOI Creative Commons

Stephan A. Ramos,

Lucas H. Armitage, J. Jason Morton

et al.

Stem Cell Reports, Journal Year: 2023, Volume and Issue: 18(4), P. 829 - 840

Published: March 23, 2023

The thymus is critical for the establishment of a functional and self-tolerant adaptive immune system but involutes with age, resulting in reduced naive T cell output. Generation human from pluripotent stem cells (hPSCs) an attractive regenerative strategy. Direct differentiation thymic epithelial progenitors (TEPs) hPSCs has been demonstrated vitro, (TECs) only form months after transplantation TEPs vivo. We show generation TECs vitro isogenic cell-derived organoids (sTOs) consisting TEPs, hematopoietic progenitor cells, mesenchymal differentiated same hPSC line. sTOs support development, express key markers negative selection, including autoimmune regulator (AIRE) protein, facilitate regulatory development. provide basis patient-specific organoid models, allowing study function, transplant immunity.

Language: Английский

Citations

24
Patients with prediabetes are at greater risk of developing diabetes 5 months postacute SARS-CoV-2 infection: a retrospective cohort study DOI Creative Commons
A Xu, Stephen Wang, Timothy Q. Duong

et al.

BMJ Open Diabetes Research & Care, Journal Year: 2023, Volume and Issue: 11(3), P. e003257 - e003257

Published: June 1, 2023

Patients with prediabetes who contract SARS-CoV-2 infection (COVID-19) could be at higher risk of developing frank diabetes compared those do not. This study aims to investigate the incidence new-onset in patients after COVID-19 and if it differs from not infected.Using electronic medical record data, 42 877 COVID-19, 3102 were identified as having a history Montefiore Health System, Bronx, New York. During same time period, 34 786 individuals without 9306 propensity matched controls. status was determined by real-time PCR test between March 11, 2020 August 17, 2022. The primary outcomes in-hospital mellitus (I-DM) persistent (P-DM) 5 months infection.Compared hospitalized prediabetes, had I-DM (21.9% vs 6.02%, p<0.001) P-DM postinfection (14.75% 7.51%, p<0.001). Non-hospitalized similar (4.15% 4.1%, p>0.05). Critical illness (HR 4.6 (95% CI 3.5 6.1), p<0.005), steroid treatment 2.88 2.2 3.8), 1.8 1.4 2.3), hemoglobin A1c (HbA1c) 1.7 1.6 1.8), p<0.005) significant predictors I-DM. 23.2 16.1 33.4), critical 2.4 HbA1c 1.3 1.1 1.4), follow-up.SARS-CoV-2 confers for post-COVID-19 COVID-19-negative counterparts prediabetes. In-hospital diabetes, illness, elevated are factors diabetes. severe disease may need more diligent monitoring postacute infection.

Language: Английский

Citations

24
Infection with SARS-CoV-2 can cause pancreatic impairment DOI Creative Commons
Wei Deng, Linlin Bao, Zhiqi Song

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 12, 2024

Abstract Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction an even higher risk of the occurrence diabetes. Herein, we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates (NHPs) models 121 vaccinated NHPs 2020 to 2023 patients. Multi-label immunofluorescence revealed direct infection both exocrine endocrine cells by virus humans. Minor limited phenotypic histopathological changes were observed adult models. Systemic proteomics metabolomics results indicated metabolic disorders, mainly enriched insulin resistance pathways, NHPs, along with elevated fasting C-peptide C-peptide/glucose ratio levels. Furthermore, elder causes loss beta (β) lower expressed-insulin situ characterized islet amyloidosis necrosis, activation α-SMA aggravated fibrosis consisting collagen serum, increase inflammation stress markers, ICAM-1 G3BP1, more severe dysfunction. In contrast, vaccination maintained glucose homeostasis activating receptor α β. Overall, cumulative diabetes post-COVID-19 is closely tied age, suggesting attention should be paid blood sugar management elderly

Language: Английский

Citations

9
Diabetes Mellitus, Energy Metabolism, and COVID-19 DOI Creative Commons
Caterina Conte, Elisa Cipponeri, Michael Roden

et al.

Endocrine Reviews, Journal Year: 2023, Volume and Issue: 45(2), P. 281 - 308

Published: Nov. 2, 2023

Abstract Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because they are not only risk factors for both acute chronic manifestations, but also alters energy metabolism. Such metabolic alterations can lead to dysglycemia long-lasting effects. Thus, the pandemic has potential a further rise of pandemic. This review outlines how preexisting spanning from excess visceral adipose tissue hyperglycemia overt may exacerbate severity. We summarize different effects SARS-CoV-2 infection on key organs tissues orchestrating metabolism, including tissue, liver, skeletal muscle, pancreas. Last, we provide an integrative view derangements that occur during COVID-19. Altogether, this allows better understanding occurring when fire starts small flame, thereby help reducing impact

Language: Английский

Citations

16