Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(11)
Published: June 1, 2024
Abstract
Diabetic
kidney
disease
(DKD)
is
a
leading
cause
of
end
stage
renal
with
unmet
clinical
demands
for
treatment.
Lipids
are
essential
cell
survival;
however,
cells
have
limited
capability
to
metabolize
overloaded
lipids.
Dyslipidaemia
common
in
DKD
patients
and
ectopic
lipid
accumulation
associated
progression.
Unveiling
the
molecular
mechanism
involved
regulation
crucial
exploring
potential
therapeutic
targets.
In
this
review,
we
focused
on
underlying
cholesterol,
oxysterol
fatty
acid
metabolism
disorder
context
DKD.
Specific
regulators
different
compartment
TREM2
macrophages,
lipid‐related
macrophages
DKD,
were
discussed.
The
role
sodium‐glucose
transporter
2
inhibitors
improving
was
summarized.
EBioMedicine,
Journal Year:
2024,
Volume and Issue:
107, P. 105294 - 105294
Published: Aug. 23, 2024
Acute
kidney
injury
(AKI)
is
a
clinical
syndrome
characterized
by
rapid
and
significant
decrease
in
renal
function
that
can
arise
from
various
etiologies,
associated
with
high
morbidity
mortality.
The
tubular
epithelial
cells
(TECs)
represent
the
central
cell
type
affected
AKI,
their
notable
regenerative
capacity
critical
for
recovery
of
afflicted
patients.
adaptive
repair
process
initiated
surviving
TECs
following
mild
AKI
facilitates
full
recovery.
Conversely,
when
severe
or
persistent,
it
allows
to
undergo
pathological
responses,
abnormal
phenotypic
transformation,
which
will
lead
development
fibrosis.
Given
implications
fate
after
outcomes,
deeper
understanding
these
mechanisms
necessary
identify
promising
therapeutic
targets
biomarkers
human
kidney.
Journal of the American Society of Nephrology,
Journal Year:
2024,
Volume and Issue:
35(3), P. 281 - 298
Published: Jan. 11, 2024
Significance
Statement
This
study
sheds
light
on
the
central
role
of
adenine
nucleotide
translocase
2
(ANT2)
in
pathogenesis
obesity-induced
CKD.
Our
data
demonstrate
that
ANT2
depletion
renal
proximal
tubule
cells
(RPTCs)
leads
to
a
shift
their
primary
metabolic
program
from
fatty
acid
oxidation
aerobic
glycolysis,
resulting
mitochondrial
protection,
cellular
survival,
and
preservation
function.
These
findings
provide
new
insights
into
underlying
mechanisms
CKD
have
potential
be
translated
toward
development
targeted
therapeutic
strategies
for
this
debilitating
condition.
Background
The
impairment
ATP
production
transport
RPTCs
has
been
linked
condition
is
characterized
by
kidney
dysfunction,
inflammation,
lipotoxicity,
fibrosis.
In
study,
we
investigated
ANT2,
which
serves
as
regulator
content
RPTCs,
Methods
We
generated
RPTC-specific
knockout
(
RPTC-ANT2
−/−
)
mice,
were
then
subjected
24-week
high-fat
diet–feeding
regimen.
conducted
comprehensive
assessment
morphology,
function,
alterations
these
mice.
addition,
used
large-scale
transcriptomics,
proteomics,
metabolomics
analyses
gain
regulating
RPTC
physiology,
overall
health.
Results
revealed
obese
mice
displayed
preserved
morphology
along
with
notable
absence
lipotoxicity
Ant2
led
fundamental
rewiring
program.
Specifically,
shifted
oxidizing
acids
energy
source
favoring
phenomenon
mediated
testis-selective
Ant4.
Conclusions
propose
significant
RPTC-Ant2
nullification
triggers
cascade
mechanisms,
including
enhanced
ultimately
shed
complex
pathways
contributing
suggest
targets
Annual Review of Immunology,
Journal Year:
2024,
Volume and Issue:
42(1), P. 207 - 233
Published: Jan. 12, 2024
The
immune
system
and
the
kidneys
are
closely
related.
Immune
components
mediate
acute
kidney
disease
crucial
to
progression
of
chronic
disease.
Beyond
its
pathogenic
functions,
supports
immunological
homeostasis
in
healthy
kidneys.
help
maintain
equilibrium
by
removing
metabolic
waste
products
toxins,
thereby
limiting
local
systemic
inflammation.
In
this
review,
we
describe
close
relationship
between
We
discuss
how
imbalance
response
can
be
deleterious
immunomodulation
important
preventing
end-stage
renal
addition,
recent
tools
such
as
silico
platforms
organoids
unveil
cells
homeostasis.
Journal of Clinical & Translational Endocrinology,
Journal Year:
2024,
Volume and Issue:
36, P. 100341 - 100341
Published: April 2, 2024
Obesity
and
chronic
kidney
disease
are
two
ongoing
progressive
clinical
pandemics
of
major
public
health
care
significance.
Because
their
growing
prevalence,
indolent
course
consequent
complications
both
these
conditions
place
significant
burden
on
the
delivery
system
especially
in
developed
countries
like
United
States.
Beyond
chance
coexistence
same
patient
based
high
prevalence
it
is
now
apparent
that
obesity
associated
with
likely
has
a
direct
causal
role
onset,
progression
severity
disease.
The
causes
underlying
pathophysiology
this
myriad,
complicated
multi-faceted.
In
review,
continuing
theme
special
edition
journal
"
Cross
roads
between
Endocrinology
Nephrology"
we
review
epidemiology
related
(ORCKD),
its
various
pathophysiology.
addition,
delve
into
comorbidities
ORCKD
particular
emphasis
cardio
metabolic
consequences
then
current
body
evidence
for
available
strategies
modulation
as
well
potential
unique
weight
reduction
management
improvement
risk
reduction.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(11)
Published: June 1, 2024
Abstract
Diabetic
kidney
disease
(DKD)
is
a
leading
cause
of
end
stage
renal
with
unmet
clinical
demands
for
treatment.
Lipids
are
essential
cell
survival;
however,
cells
have
limited
capability
to
metabolize
overloaded
lipids.
Dyslipidaemia
common
in
DKD
patients
and
ectopic
lipid
accumulation
associated
progression.
Unveiling
the
molecular
mechanism
involved
regulation
crucial
exploring
potential
therapeutic
targets.
In
this
review,
we
focused
on
underlying
cholesterol,
oxysterol
fatty
acid
metabolism
disorder
context
DKD.
Specific
regulators
different
compartment
TREM2
macrophages,
lipid‐related
macrophages
DKD,
were
discussed.
The
role
sodium‐glucose
transporter
2
inhibitors
improving
was
summarized.
