Mechanisms and possible hepatoprotective effects of glucagon-like peptide-1 receptor agonists and other incretin receptor agonists in non-alcoholic fatty liver disease

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2023, Volume and Issue: 8(2), P. 179 - 191

Published: Jan. 5, 2023

Language: Английский

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Targeting the incretin system in obesity and type 2 diabetes mellitus

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(8), P. 447 - 459

Published: April 17, 2024

Language: Английский

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Stress-sensitive neural circuits change the gut microbiome via duodenal glands

Cell, Journal Year: 2024, Volume and Issue: 187(19), P. 5393 - 5412.e30

Published: Aug. 8, 2024

Negative psychological states impact immunity by altering the gut microbiome. However, relationship between brain and microbiome composition remains unclear. We show that Brunner's glands in duodenum couple stress-sensitive circuits to bacterial homeostasis. mediated enrichment of Lactobacillus species response vagus nerve stimulation. Cell-specific ablation markedly suppressed Lactobacilli counts heightened vulnerability infection. In forebrain, we mapped a vagally mediated, polysynaptic circuit connecting central nucleus amygdala glands. Chronic stress activity phenocopied effects gland lesions. Conversely, excitation either or parasympathetic vagal neurons activated reversed on immunity. The findings revealed tractable brain-body mechanism linking host defense.

Language: Английский

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Acetate enables metabolic fitness and cognitive performance during sleep disruption

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(9), P. 1998 - 2014.e15

Published: Aug. 19, 2024

Language: Английский

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Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The hippocampus (HPC) has emerged as a critical player in the control of food intake, beyond its well-known role memory. While previous studies have primarily associated HPC with intake inhibition, recent research suggests appetitive processes. Here we identified spatially distinct neuronal populations within dorsal (dHPC) that respond to either fats or sugars, potent natural reinforcers contribute obesity development. Using activity-dependent genetic capture nutrient-responsive dHPC neurons, demonstrate causal both promoting nutrient-specific through different mechanisms. Sugar-responsive neurons encoded spatial memory for sugar location, whereas fat-responsive selectively enhanced preference and motivation fat intake. Importantly, stimulation increased while ablation differentially impacted obesogenic diet consumption prevented diet-induced weight gain. Collectively, these findings uncover previously unknown orexigenic circuits underlying macronutrient-specific provide foundation developing potential treatments. Yang et al. identify characterize sugar- their contribution development obesity.

Language: Английский

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Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 24, 2025

The visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. A small subset innervate liver project centrally to nucleus tractus solitarius, area postrema, dorsal motor vagus, peripherally periportal areas liver. loss these prevents diet-induced obesity, outcomes are associated with increased expenditure. Although males females exhibit improved glucose homeostasis following disruption only male display insulin sensitivity. Furthermore, limits progression steatosis. Intriguingly, lacking liver-innervating also less compared control mice. Modulation liver-brain axis may aid designing effective treatments both psychiatric metabolic disorders obesity MAFLD. Liver-projecting play a key role regulating Modulating via vagus nerve offer promising therapeutic approach improving lipid metabolism, homeostasis, affective diabetes.

Language: Английский

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Skeletal interoception in bone homeostasis and pain

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(12), P. 1914 - 1931

Published: Oct. 17, 2022

Language: Английский

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The Metabolic Role and Therapeutic Potential of the Microbiome

Endocrine Reviews, Journal Year: 2022, Volume and Issue: 43(5), P. 907 - 926

Published: Jan. 30, 2022

We are host to an assembly of microorganisms that vary in structure and function along the length gut from lumen mucosa. This ecosystem is collectively known as microbiota significant efforts have been spent during past 2 decades catalog functionally describe normal how it varies a wide spectrum disease states. The altered several cardiometabolic diseases recent work has established microbial signatures may advance disease. However, most research focused on identifying associations between human states investigate causality potential mechanisms using cells animals. Since functions intersection diet metabolism, can contribute inflammation, microbially produced metabolites molecules modulate diseases. Here we discuss bacterial composition in, to, disease, well bacteria be targeted treat prevent metabolic

Language: Английский

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Neural signalling of gut mechanosensation in ingestive and digestive processes

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(3), P. 135 - 156

Published: Jan. 4, 2022

Language: Английский

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Boundaries and integration between microbiota, the nervous system, and immunity

Immunity, Journal Year: 2023, Volume and Issue: 56(8), P. 1712 - 1726

Published: Aug. 1, 2023

Language: Английский

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