Prodromic Inflammatory–Oxidative Stress in Peritoneal Leukocytes of Triple-Transgenic Mice for Alzheimer’s Disease DOI Open Access
Noemí Ceprián, Irene Martínez de Toda,

Ianire Maté

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6976 - 6976

Published: June 26, 2024

Inflammatory–oxidative stress is known to be pivotal in the pathobiology of Alzheimer’s disease (AD), but involvement this at peripheral level disease’s onset has been scarcely studied. This study investigated pro-inflammatory profile and oxidative parameters peritoneal leukocytes from female triple-transgenic mice for AD (3xTgAD) non-transgenic (NTg). Peritoneal were obtained 2, 4, 6, 12, 15 months age. The concentrations TNFα, INFγ, IL-1β, IL-2, IL-6, IL-17, IL-10 released cultures without stimuli mitogen concanavalin A lipopolysaccharide presence measured. reduced glutathione (GSH), oxidized (GSSG), lipid peroxidation, Hsp70 also analyzed cells. Our results showed that although there was a lower release cytokines by 3xTgAD mice, response uncontrolled overstimulated, especially prodromal stage 2 In addition, GSH higher amounts peroxides 4 months, as well as, 6 concentration Hsp70. conclusion, show worse than NTg during stages, potentially supporting idea could consequence alteration leukocyte inflammation–oxidation state.

Language: Английский

The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review DOI Creative Commons
Shengwen Lu, Qiqi Zhao, Yu Guan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117207 - 117207

Published: July 26, 2024

Language: Английский

Citations

16
The gut microbiota-immune-brain axis: Therapeutic implications DOI Creative Commons
Kenneth J. O’Riordan, Gerard M. Moloney, Lily Keane

et al.

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101982 - 101982

Published: March 1, 2025

Language: Английский

Citations

1
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution DOI
Zhisheng Wu, Yiheng Wang, Weiwei Chen

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
The effects of dietary L-theanine on the growth performance, non-specific immunity, antioxidant status, and intestinal microflora of female Chinese mitten crabs (Eriocheir sinensis) DOI Creative Commons

Min Yang,

Tingshuang Pan, Tong Li

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 34, P. 101923 - 101923

Published: Jan. 11, 2024

L-theanine, a non-protein amino acid in tea, has been widely studied as an immune enhancer poultry, livestock, and rodents. However, no studies have performed on the application of L-theanine aquaculture feed. To fill this research gap, we investigated effects feed additive growth performance, function, antioxidant capacity, intestinal flora female Chinese mitten crab (Eriocheir sinensis) using biochemical assays, real-time polymerase chain reaction, 16 S rRNA gene sequencing. In total, 300 one-year-old crabs were randomly divided into treatment groups supplemented with 0 (control), 0.5%, 1.0%, 1.5%, 2.0% (L0–L4, respectively; n = 4 replicates per group 15 replicate). After eight weeks, total edible yield was significantly higher all than L0 (P < 0.05). Furthermore, muscle (both P 0.01) hepatopancreas index 0.01 0.05, respectively) L2 L3 group. The gonadosomatic also 0.01). Moreover, superoxide dismutase, phosphatase, glutathione peroxidase activities increased, malondialdehyde content decreased compared to Anti-lipopolysaccharide factor (ALF) 2 (i.e., ALF2), Toll-like receptor TLR), myeloid differentiation primary response 88 Myd88) expression up-regulated L2, L3, L4 <0.01), ALF1 mammalian target rapamycin mTOR) <0.01) Overall, these results suggest that supplementation 0.5–1.0% positively affected gut microbiota composition crabs, improving their fraction, immunity, abundance.

Language: Английский

Citations

6
Gut Microbiota as a Modifier of Huntington’s Disease Pathogenesis DOI Creative Commons
Ali Khoshnan

Journal of Huntington s Disease, Journal Year: 2024, Volume and Issue: 13(2), P. 133 - 147

Published: May 10, 2024

Huntingtin (HTT) protein is expressed in most cell lineages, and the toxicity of mutant HTT multiple organs may contribute to neurological psychiatric symptoms observed Huntington's disease (HD). The proteostasis neurotoxicity are influenced by intracellular milieu responses environmental signals. Recent research has highlighted a prominent role gut microbiota brain immune system development, aging, progression disorders. Several studies suggest that might disrupt homeostasis (known as dysbiosis) impact pathogenesis HD. Dysbiosis been HD patients, animal models it coincides with aggregation, abnormal behaviors, reduced lifespan. This review article aims highlight potential pathways within microbiota-gut-immune-central nervous (CNS) axis. Understanding functions Wild-Type (WT) these associated networks elucidate novel pathogenic pathways, identify biomarkers peripheral therapeutic targets for

Language: Английский

Citations

6
Fibre & fermented foods: differential effects on the microbiota-gut-brain axis DOI Creative Commons
Elizabeth M. Schneider, Ramya Balasubramanian,

Aimone Ferri

et al.

Proceedings of The Nutrition Society, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Oct. 25, 2024

The ability to manipulate brain function through the communication between microorganisms in gastrointestinal tract and along gut-brain axis has emerged as a potential option improve cognitive emotional health. Dietary composition patterns have demonstrated robust capacity modulate microbiota-gut-brain axis. With their possess pre-, pro-, post-, synbiotic properties, dietary fibre fermented foods stand out potent shapers of gut microbiota subsequent signalling brain. Despite this potential, few studies directly examined mechanisms that might explain beneficial action on axis, thus limiting insight treatments for dysfunction. Herein, we evaluate differential effects from whole food sources functioning. Potential mediating health via are described. Although more multimodal research combines psychological assessments biological sampling compare each type is needed, evidence accumulated date suggests fibre, foods, and/or combination within psychobiotic diet can be cost-effective convenient approach functioning across lifespan.

Language: Английский

Citations

6
Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases DOI Creative Commons

Xinjie Qin,

Zinan Fang,

Jinkang Zhang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 18, 2024

Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal nutritional health care values. Among them, polysaccharides, triterpenoids, oligosaccharides, trace elements, etc. are important bioactive components in G. . These will have an impact on gut flora, thus alleviating diseases such hyperglycemia, hyperlipidemia obesity caused flora disorder. While numerous studies demonstrated ability of its active to regulate systematic review mechanism currently lacking. The purpose paper summarize regulatory effects cardiovascular, gastrointestinal renal metabolic diseases, research progress improving related regulating flora. Additionally, delves into principle which can treat or assist intestinal tract medicine, food clinical application were fully explored for researchers.

Language: Английский

Citations

5
Gut microbiota and atrial cardiomyopathy DOI Creative Commons

Tingting Sun,

Beibei Song, Bo Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Language: Английский

Citations

0
Gut microbiota composition is altered in postural orthostatic tachycardia syndrome and post-acute COVID-19 syndrome DOI Creative Commons
Viktor Hamrefors, Fredrik Kahn, Madlene Holmqvist

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 9, 2024

Abstract Postural Orthostatic Tachycardia Syndrome (POTS) reflects an autonomic dysfunction, which can occur as a complication to COVID-19. Our aim was examine gastrointestinal symptoms and gut microbiota composition in patients with POTS post-acute COVID-19 syndrome (PACS), compared controls. ( n = 27), PACS 32) controls 39) delivered fecal samples completed 4-day food diary, irritable bowel syndrome-severity scoring system (IBS-SSS), visual analog scale for IBS (VAS-IBS). A total of 98 DNA aliquots were sequenced average depth 28.3 million (M) read pairs (Illumina 2 × 150 PE) per sample. Diversity taxonomic levels the microbiome, well functional abundances calculated groups, then There several differences between controls, whereas only abundance Ascomycota Firmicutes differed The clinical variables IBS-SSS, fatigue, bloating flatulence significantly correlated multiple individual taxa abundances, alpha diversity, abundances. We conclude that POTS, less extent PACS, are associated diversity at levels. Clinical both

Language: Английский

Citations

4
Research progress on intestinal microbiota regulating cognitive function through the gut-brain axis DOI

Kaijie Lin,

Feng Peng,

Kunyang He

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(8), P. 3711 - 3721

Published: April 17, 2024

Language: Английский

Citations

4