Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
14(3), P. 953 - 1008
Published: Dec. 16, 2023
Cancer
reprogramming
is
an
important
facilitator
of
cancer
development
and
survival,
with
tumor
cells
exhibiting
a
preference
for
aerobic
glycolysis
beyond
oxidative
phosphorylation,
even
under
sufficient
oxygen
supply
condition.
This
metabolic
alteration,
known
as
the
Warburg
effect,
serves
significant
indicator
malignant
transformation.
The
effect
primarily
impacts
occurrence
by
influencing
pathway
in
cells.
Key
enzymes
involved
this
process
include
glucose
transporters
(GLUTs),
HKs,
PFKs,
LDHs,
PKM2.
Moreover,
expression
transcriptional
regulatory
factors
proteins,
such
FOXM1,
p53,
NF-
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Nov. 1, 2022
Colorectal
cancer
(CRC)
is
the
third
most
common
and
second
leading
cause
of
cancer-related
death
worldwide.
Countless
CRC
patients
undergo
disease
progression.
As
a
hallmark
cancer,
Warburg
effect
promotes
metastasis
remodels
tumor
microenvironment,
including
promoting
angiogenesis,
immune
suppression,
cancer-associated
fibroblasts
formation
drug
resistance.
Targeting
metabolism
would
be
promising
method
for
treatment
CRC.
In
this
review,
we
summarize
information
about
roles
in
microenvironment
to
elucidate
mechanisms
governing
identify
novel
targets
therapy.
Neuro-Oncology Advances,
Journal Year:
2023,
Volume and Issue:
5(1)
Published: Jan. 1, 2023
Glioblastoma
(GBM)
tumor
microenvironment
(TME)
is
a
highly
heterogeneous
and
complex
system,
which
in
addition
to
cancer
cells,
consists
of
various
resident
brain
immune
cells
as
well
transit
through
the
such
marrow-derived
cells.
The
TME
dynamic
environment
heavily
influenced
by
alterations
cellular
composition,
cell-to-cell
contact
metabolic
products
other
chemical
factors,
pH
oxygen
levels.
Emerging
evidence
suggests
that
GBM
appear
reprogram
their
TME,
hijack
microenvironmental
elements
facilitate
rapid
proliferation,
invasion,
migration,
survival
thus
generating
treatment
resistance.
interact
with
directly
interaction
mediated
cell-surface
molecules,
or
indirectly
apocrine
paracrine
signaling
via
cytokines,
growth
extracellular
vehicles.
recent
discovery
neuron-glioma
interfaces
neurotransmitter-based
interactions
has
uncovered
novel
mechanisms
favor
cell
growth.
Here,
we
review
known
emerging
related
communication
between
components
its
discuss
models
for
studying
outline
current
studies
targeting
therapeutic
purposes.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 18, 2024
Abstract
Cancer,
a
complex
and
multifactorial
disease,
presents
significant
challenge
to
global
health.
Despite
advances
in
surgical,
radiotherapeutic
immunological
approaches,
which
have
improved
cancer
treatment
outcomes,
drug
therapy
continues
serve
as
key
therapeutic
strategy.
However,
the
clinical
efficacy
of
is
often
constrained
by
resistance
severe
toxic
side
effects,
thus
there
remains
critical
need
develop
novel
therapeutics.
One
promising
strategy
that
has
received
widespread
attention
recent
years
repurposing:
identification
new
applications
for
existing,
clinically
approved
drugs.
Drug
repurposing
possesses
several
inherent
advantages
context
since
repurposed
drugs
are
typically
cost-effective,
proven
be
safe,
can
significantly
expedite
development
process
due
their
already
established
safety
profiles.
In
light
this,
present
review
offers
comprehensive
overview
various
methods
employed
repurposing,
specifically
focusing
on
treat
cancer.
We
describe
antitumor
properties
candidate
drugs,
discuss
detail
how
they
target
both
hallmarks
tumor
cells
surrounding
microenvironment.
addition,
we
examine
innovative
integrating
with
nanotechnology
enhance
topical
delivery.
also
emphasize
role
play
when
used
part
combination
regimen.
To
conclude,
outline
challenges
associated
consider
future
prospects
these
transitioning
into
application.
Cancer Cell International,
Journal Year:
2022,
Volume and Issue:
22(1)
Published: Sept. 15, 2022
Abstract
The
PI3K-Akt-mechanistic
(formerly
mammalian)
target
of
the
rapamycin
(mTOR)
signaling
pathway
is
important
in
a
variety
biological
activities,
including
cellular
proliferation,
survival,
metabolism,
autophagy,
and
immunity.
Abnormal
PI3K-Akt-mTOR
signalling
activation
can
promote
transformation
by
creating
environment
conducive
to
it.
Deregulation
such
system
terms
genetic
mutations
amplification
has
been
related
several
human
cancers.
Consequently,
mTOR
recognized
as
key
for
treatment
cancer,
especially
treating
cancers
with
elevated
due
or
metabolic
disorders.
In
vitro
vivo,
which
an
immunosuppressant
agent
actively
suppresses
activity
reduces
cancer
cell
growth.
As
result,
various
sirolimus-derived
compounds
have
now
established
therapies
these
medications
are
being
investigated
clinical
studies.
this
updated
review,
we
discuss
usage
other
drugs
preclinical
studies
well
explain
some
challenges
involved
targeting
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2022,
Volume and Issue:
18(1), P. 467 - 492
Published: Nov. 2, 2022
Reprogrammed
metabolism
is
a
hallmark
of
colorectal
cancer
(CRC).
CRC
cells
are
geared
toward
rapid
proliferation,
requiring
nutrients
and
the
removal
cellular
waste
in
nutrient-poor
environments.
Intestinal
stem
(ISCs),
primary
cell
origin
for
CRCs,
must
adapt
their
along
adenoma-carcinoma
sequence
to
unique
features
complex
microenvironment
that
include
interactions
with
intestinal
epithelial
cells,
immune
stromal
commensal
microbes,
dietary
components.
Emerging
evidence
implicates
modifiable
risk
factors
related
environment,
such
as
diet,
important
pathogenesis.
Here,
we
focus
on
describing
ISCs,
diets
influence
initiation,
genetics
metabolism,
tumor
microenvironment.
The
mechanistic
links
between
environmental
factors,
metabolic
adaptations,
enhancing
or
supporting
tumorigenesis
becoming
better
understood.
Thus,
greater
knowledge
holds
promise
improved
prevention
treatment.
