Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(10), P. 854 - 871
Published: June 12, 2024
Language: Английский
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 3, 2024
Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture intracellular content release. Originally investigated as targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential complement chemotherapy, immunotherapy, radiotherapy in various types. However, it can lead side effects, including immune death, bone marrow impairment, liver kidney damage, cachexia (severe weight loss muscle wasting), secondary tumorigenesis. In this review, we discuss the advantages offer an overview diverse range documented effects. Furthermore, examine underlying mechanisms explore strategies effect mitigation.
Language: Английский
Citations
28
Advanced Science, Journal Year: 2024, Volume and Issue: 11(24)
Published: April 19, 2024
Abstract Preventing and treating avascular necrosis at the distal end of flaps are critical to surgery success, but current treatments not ideal. A recent study shows that apoptotic bodies (ABs) generated near site apoptosis can be taken up promote cell proliferation. The reveals ABs derived from fibroblast‐like cells in subcutaneous connective tissue (FSCT cells) skin promoted ischaemic flap survival. It is also found inhibited death oxidative stress M1‐to‐M2 polarization macrophages. Transcriptome sequencing protein level testing demonstrated survival endothelial macrophages by inhibiting ferroptosis via KEAP1‐Nrf2 axis. Furthermore, microRNA (miR) data vitro vivo experiments KEAP1 delivering miR‐339‐5p exert therapeutic effects. In conclusion, FSCT cell‐derived ferroptosis, macrophage transition miR‐339‐5p/KEAP1/Nrf2 axis These results provide a potential strategy administering ABs.
Language: Английский
Citations
18
Molecular Cell, Journal Year: 2024, Volume and Issue: 84(16), P. 3098 - 3114.e6
Published: Aug. 1, 2024
Language: Английский
Citations
16
Nature Cell Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Language: Английский
Citations
3
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 7, 2025
Sodium aescinate (SA), a natural plant extract with various bioactivities, is widely used to treat oedema and inflammation in clinics. However, adverse events, including liver injury, kidney phlebitis, have been reported patients SA recent years. In this study, we BALB/c mice L02 cells evaluate the role of ferroptosis SA-induced injury. significantly increased AST, ALT, MDA Fe2+, decreased GSH levels, induced pathological changes vivo. also reduced viability LDH release, intracellular cysteine reduction, depletion, iron accumulation, ROS production, lipid peroxidation, indicating that causes ferroptosis. addition, inhibited transcriptional activity activating transcription factor 4 (ATF4) subsequently expression downstream genes xCT (solute carrier family 7a member 11, SLC7A11) Cystathionine gamma-lyase (CTH) which play vital roles biosynthesis. Interestingly, cytotoxic effects were effectively attenuated by ATF4 overexpression, while they aggravated silencing. These results revealed triggers hepatocyte inhibiting ATF4, an oxidative imbalance.
Language: Английский
Citations
2
Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(11), P. 1872 - 1886
Published: Nov. 1, 2023
Language: Английский
Citations
39
Nature Structural & Molecular Biology, Journal Year: 2023, Volume and Issue: 30(9), P. 1295 - 1302
Published: Aug. 7, 2023
Language: Английский
Citations
30
Molecular Cell, Journal Year: 2023, Volume and Issue: 83(20), P. 3740 - 3753.e9
Published: Oct. 1, 2023
Language: Английский
Citations
24
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: Nov. 6, 2023
Cardiovascular diseases (CVDs) are one of the primary causes mortality worldwide. An optimal mitochondrial function is central to supplying tissues with high energy demand, such as cardiovascular system. In addition producing ATP a power source, mitochondria also heavily involved in adaptation environmental stress and fine-tuning tissue functions. Mitochondrial quality control (MQC) through fission, fusion, mitophagy, biogenesis ensures clearance dysfunctional preserves homeostasis tissues. Furthermore, generate reactive oxygen species (ROS), which trigger production pro-inflammatory cytokines regulate cell survival. dysfunction has been implicated multiple CVDs, including ischemia-reperfusion (I/R), atherosclerosis, heart failure, cardiac hypertrophy, hypertension, diabetic genetic cardiomyopathies, Kawasaki Disease (KD). Thus, MQC pivotal promoting health. Here, we outline mechanisms discuss current literature on CVDs.
Language: Английский
Citations
24
Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)
Published: Nov. 9, 2023
Abstract Ferroptosis, which is caused by iron‐dependent accumulation of lipid peroxides, an emerging form regulated cell death and considered a potential target for cancer therapy. However, the regulatory mechanisms underlying ferroptosis remain unclear. This study defines distinctive role ferroptosis. Inhibition CARM1 can increase sensitivity tumor cells to inducers in vitro vivo. Mechanistically, it found that ACSL4 methylated at arginine 339 (R339). Furthermore, R339 methylation promotes RNF25 binding ACSL4, contributes ubiquitylation ACSL4. The blockade facilitates effectively enhances ferroptosis‐associated immunotherapy. Overall, this demonstrates critical contributor resistance highlights as candidate therapeutic improving effects ferroptosis‐based antitumor
Language: Английский
Citations
23