AJP Endocrinology and Metabolism,
Journal Year:
2024,
Volume and Issue:
327(6), P. E760 - E772
Published: Nov. 13, 2024
Metabolic
diseases,
including
obesity,
dyslipidemia,
and
type
2
diabetes,
have
become
severe
challenges
worldwide.
The
developmental
origins
of
health
disease
(DOHaD)
hypothesis
suggests
that
an
adverse
intrauterine
environment
can
increase
the
risk
metabolic
disorders
in
offspring.
Studies
demonstrated
maternal
exercise
is
effective
intervention
for
improving
offspring
health.
However,
pathways
through
which
works
are
unclear.
It
has
been
reported
gut
microbiota
mediates
effect
on
metabolism,
epigenetic
modifications
also
proposed
to
be
important
molecular
mechanisms.
Microbial
metabolites
influence
epigenetics
by
providing
substrates
DNA
or
histone
modifications,
binding
G-protein
coupled
receptors
affect
downstream
pathways,
regulating
activity
modifying
enzymes.
This
review
aims
summarize
intergenerational
proposes
microbiota-metabolites-epigenetic
regulation
mechanism
improves
may
yield
novel
targets
early
prevention
diseases.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 1975 - 1975
Published: Sept. 1, 2024
Regular
exercise
and
physical
activity
are
now
considered
lifestyle
factors
with
positive
effects
on
human
health.
Physical
reduces
disease
burden,
protects
against
the
onset
of
pathologies,
improves
clinical
course
disease.
Unlike
pharmacological
therapies,
mediated
by
not
limited
to
a
specific
target
organ
but
act
in
multiple
biological
systems
simultaneously.
Despite
substantial
health
benefits
training,
precise
molecular
signaling
processes
that
lead
structural
functional
tissue
adaptation
remain
largely
unknown.
Only
recently,
several
bioactive
molecules
have
been
discovered
produced
following
exercise.
These
collectively
called
“exerkines”.
Exerkines
released
from
various
tissues
response
exercise,
play
crucial
role
mediating
beneficial
body.
Major
discoveries
involving
exerkines
highlight
their
diverse
functions
implications,
particularly
metabolic
regulation,
neuroprotection,
muscle
adaptation.
molecules,
including
peptides,
nucleic
acids,
lipids,
microRNAs,
through
paracrine,
endocrine,
autocrine
pathways
exert
organs
tissues.
represent
complex
network
mediate
Their
roles
importance
maintaining
preventing
Frontiers in Psychiatry,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 28, 2024
Background
Mental
health
symptoms
such
as
anxiety,
depression,
stress,
and
burnout
are
common
among
healthcare
workers.
However,
the
interconnections
them
remain
under-explored.
This
study
aimed
to
address
interrelationships
these
in
psychiatric
nurses.
Methods
We
conducted
a
nationwide
survey
early
stage
of
COVID-19
pandemic
(January
March
2021)
investigate
interconnectedness
Using
network
analysis,
we
identified
central
symptoms,
important
bridge
correlations
symptoms.
Results
Of
9,224
nurses
(79.2%
female)
included
statistical
analyses,
27.6%
reported
clinically
significant
31.2%
14.5%
23.8%
burnout.
Network
analysis
revealed
that
stress
had
highest
expected
influence
(EI)
value
(0.920)
strength
all
nodes.
The
node
for
depression
scored
both
closeness
betweenness.
Emotional
exhaustion
(EE)
(BEI)
0.340,
with
strongest
intergroup
association
between
EE
depression.
No
differences
were
found
gender
or
frontline
work
experience
(all
p
>
0.05).
Conclusions
Burnout,
relatively
context
pandemic.
While
anxiety
was
most
prevalent,
emerged
core
symptom,
an
bridging
node.
Interventions
targeting
nodes
may
improve
mental
AJP Endocrinology and Metabolism,
Journal Year:
2024,
Volume and Issue:
327(6), P. E760 - E772
Published: Nov. 13, 2024
Metabolic
diseases,
including
obesity,
dyslipidemia,
and
type
2
diabetes,
have
become
severe
challenges
worldwide.
The
developmental
origins
of
health
disease
(DOHaD)
hypothesis
suggests
that
an
adverse
intrauterine
environment
can
increase
the
risk
metabolic
disorders
in
offspring.
Studies
demonstrated
maternal
exercise
is
effective
intervention
for
improving
offspring
health.
However,
pathways
through
which
works
are
unclear.
It
has
been
reported
gut
microbiota
mediates
effect
on
metabolism,
epigenetic
modifications
also
proposed
to
be
important
molecular
mechanisms.
Microbial
metabolites
influence
epigenetics
by
providing
substrates
DNA
or
histone
modifications,
binding
G-protein
coupled
receptors
affect
downstream
pathways,
regulating
activity
modifying
enzymes.
This
review
aims
summarize
intergenerational
proposes
microbiota-metabolites-epigenetic
regulation
mechanism
improves
may
yield
novel
targets
early
prevention
diseases.
