Long non-coding RNAs-Sphingolipid Metabolism Nexus: Potential Targets for Cancer Treatment DOI Creative Commons
Runsheng Chen, J H Dai, Peng Chen

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107539 - 107539

Published: Dec. 1, 2024

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis. Sphingolipid metabolism has garnered interest a potential target for therapy owing its considerable diagnostic prognostic value. Recent studies demonstrated that lncRNAs regulate tumor-associated metabolic reprogramming via sphingolipid metabolism. However, the precise nature interactions between remains unclear. This review summarizes key roles in We emphasize interaction influences their impact on both prognosis drug resistance. These findings suggest lncRNA-sphingolipid holds great newl treatment.

Language: Английский

Developmental and Evolutionary Heart Adaptations Through Structure–Function Relationships DOI Creative Commons
Mark Phillips, Marina Nimmo, Sandra Rugonyi

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2025, Volume and Issue: 12(3), P. 83 - 83

Published: Feb. 22, 2025

While the heart works as an efficient pump, it also has a high level of adaptivity by changing its structure to maintain function during healthy and diseased states. In this Review, we present examples structure–function relationships across species throughout embryonic development in mammals birds. We summarize current research on avian models aiming at understanding how biophysical biological mechanisms closely interact formation. conclude underscoring similarities between cardiac adaptations structural changes over developmental evolutionary time scales behind these can help prevent or alleviate effects malformations contribute regeneration efforts.

Language: Английский

Citations

0
Transcriptional, proteomic and metabolic drivers of cardiac regeneration DOI Creative Commons

Matthew S. Cook,

Sean Lal, Robert D. Hume

et al.

Heart, Journal Year: 2025, Volume and Issue: unknown, P. heartjnl - 325442

Published: March 4, 2025

Following injury, many organs are capable of rapid regeneration necrotic tissue to regain normal function. In contrast, the damaged heart typically replaces with a collagen-rich scar, due limited regenerative capacity its functional contractile cardiomyocytes (CMs). However, this varies dramatically during development and between species. Furthermore, studies have shown that cardiac can be enhanced return function following myocardial infarction (MI). review, we outline proliferative CMs in utero, postnatally adulthood. We also describe MI injury. Finally, focus on various therapeutic strategies aim augment preclinical animal models. These include altering transcripts, microRNAs, extracellular matrix proteins inducing metabolic rewiring. Together, these therapies potentially improve lives millions failure patients currently suffering worldwide.

Language: Английский

Citations

0
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation DOI
Tim Koopmans,

Eva van Rooij

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

0
Cell cycle arrest of cardiomyocytes in the context of cardiac regeneration DOI Creative Commons
Qingling Xu, Xinhui Chen, Chenchen Zhao

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

The limited capacity of adult mammalian cardiomyocytes to undergo cell division and proliferation is one the key factors contributing heart failure. In newborn mice, cardiac occurs during a brief window, but this proliferative diminishes by 7 days after birth. Current studies on regeneration focused elucidating changes in regulatory within before aiming determine whether potential association between these cycle arrest cardiomyocytes. Facilitating re-entry into or reversing their exit from it represents critical strategy for regeneration. This paper provides an overview role regeneration, briefly describes cardiomyocyte systematically summarizes regulation cardiomyocytes, metabolic mechanisms underlying arrest. Additionally, we highlight development cardiovascular disease drugs targeting status clinical treatment. Our goal outline strategies promoting repair following injury, while also pointing toward future research directions that may offer new technologies prospects treating diseases, such as myocardial infarction, arrhythmia

Language: Английский

Citations

0
Contribution of gut-derived T cells to extraintestinal autoimmune diseases DOI
Qiaolin Wang,

Yutong Wu,

Qianjin Lu

et al.

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(9), P. 639 - 648

Published: Aug. 23, 2024

Language: Английский

Citations

2
CXCL4 deficiency limits M4 macrophage infiltration and attenuates hyperoxia-induced lung injury DOI Creative Commons

Bingrui Yu,

Siyuan Jia,

Yu Chen

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Language: Английский

Citations

2
Sphingosine‐1‐phosphate signalling in the heart: exploring emerging perspectives in cardiopathology DOI Creative Commons
Franck Phan, Olivier Bourron, Fabienne Foufelle

et al.

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(21), P. 2641 - 2655

Published: July 4, 2024

Cardiometabolic disorders contribute to the global burden of cardiovascular diseases. Emerging sphingolipid metabolites like sphingosine‐1‐phosphate (S1P) and its receptors, S1PRs, present a dynamic signalling axis significantly impacting cardiac homeostasis. S1P's intricate mechanisms extend transportation in bloodstream by two specific carriers: high‐density lipoprotein particles albumin. This transport system ensures accessibility S1P distant target tissues, influencing several physiological processes critical for health. review delves into diverse functions S1PRs both pathophysiological conditions heart. Emphasis is placed on their roles modulating health, spanning from contractility, angiogenesis, inflammation, atherosclerosis myocardial infarction. The interplays involving receptors are analysed concerning different cell types, shedding light respective heart We also therapeutic applications targeting S1P/S1PRs diseases, considering existing drugs Fingolimod, as well prospects challenges developing novel therapies that selectively modulate S1PRs.

Language: Английский

Citations

1
Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration DOI Creative Commons
Yongyu Wang, Yalin Wu, Yu Jiang

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Background The proliferative capacity of cardiomyocytes in adult mammalian hearts is far too low to replace the cells that are lost myocardial infarction. Both cardiomyocyte proliferation and regeneration can be improved via overexpression a constitutively active variant YAP5SA (Yes‐associated protein, 5SA [active] mutant), but persistent proliferation‐inducing genes could lead hypertrophy arrhythmia, whereas off‐target expression fibroblasts macrophages increase fibrosis inflammation. Methods Results Transient or GFP (green fluorescent protein; control) was targeted our cardiomyocyte‐specific modified mRNA translation system ( CM‐SMRTs CM‐SMRTs, respectively). YAP5SA‐cardiomyocyte specificity confirmed vitro experiments cardiac had been differentiated from human induced‐ pluripotent stem umbilical‐vein endothelial cells, regenerative potency evaluated mouse infarction model. In cultured induced‐pluripotent cells‐cardiomyocytes, YAP abundantly expressed for 3 days after administration accompanied by increases markers proliferation, before declining near‐background levels day 7, fluorescence remained high 1 treatment then slowly declined. also observed cells‐cardiac on declined substantially 3. model, echocardiographic assessments left‐ventricular ejection fraction fractional shortening were significantly greater, infarct sizes smaller CM‐SMRTs–treated mice than vehicle‐treated control animals, appeared promote proliferation. Conclusions used transiently specifically overexpress cardiomyocytes, this strategy promoted

Language: Английский

Citations

1
Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration DOI Creative Commons

Kexiao Zheng,

Yanglin Hao,

Chenkun Xia

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 10, 2024

The adult mammalian cardiomyocyte has a limited capacity for self-renewal, which leads to the irreversible heart dysfunction and poses significant threat myocardial infarction patients. In past decades, research efforts have been predominantly concentrated on proliferation regeneration. However, is complex organ that comprises not only cardiomyocytes but also numerous noncardiomyocyte cells, all playing integral roles in maintaining cardiac function. addition, are exposed dynamically changing physical environment includes oxygen saturation mechanical forces. Recently, growing number of studies microenvironment regeneration ongoing. this review, we provide an overview recent advances microenvironment, plays important role

Language: Английский

Citations

1
Protocol to evaluate rat and mouse cardiomyocyte proliferation in vitro and in vivo DOI Creative Commons
Bin Li, Wei Yan, Yijie Guo

et al.

STAR Protocols, Journal Year: 2024, Volume and Issue: 5(3), P. 103204 - 103204

Published: July 21, 2024

Here, we present a protocol for the quantitative assessment of rat and mouse cardiomyocyte proliferation both in vitro vivo. For vivo approach, describe steps isolation neonatal cardiomyocytes employment various indicators to quantify cell proliferation. We then detail procedures that incorporate comprehensive assays genetic lineage tracing strategy evaluate endogenous This can be modified investigate other mammalian complete details on use execution this protocol, please refer Ji et al.

Language: Английский

Citations

0