Molecular Metabolism,
Journal Year:
2024,
Volume and Issue:
91, P. 102067 - 102067
Published: Nov. 14, 2024
Infiltration
of
adipocytes
into
the
pancreatic
parenchyma
has
been
linked
to
impaired
insulin
secretion
in
individuals
with
increased
genetic
risk
T2D
and
prediabetic
conditions.
However,
study
this
ectopic
fat
depot
limited
by
lack
suitable
vitro
models.
Here,
we
developed
a
novel
3D
model
functionally
mature
human
adipose
tissue
organoids
aggregating
tissue-derived
stromal
vascular
fraction
(SVF)
cells
differentiating
them
over
19
days.
These
carry
biological
properties
situ
fat,
presenting
levels
adipogenic
markers
comparable
native
improved
lipolytic
anti-lipolytic
response
compared
conventional
2D
cultures.
The
harbour
small
population
immune
cells,
mimicking
vivo
environment.
Furthermore,
they
express
GIPR,
allowing
investigation
incretin
effects
fat.
In
accordance,
GIP
dual
GLP1R/GIPR
agonist
tirzepatide
stimulate
lipolysis
but
had
distinct
on
expression
proinflammatory
cytokines.
This
organoid
is
valuable
tool
metabolic
impact
signalling
tissue,
revealing
potential
therapeutic
targets
incretins
beyond
islets.
donor-specific
memory
these
enables
examination
fat-islet
crosstalk
donor-related
context.
Mathematical Biosciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109433 - 109433
Published: April 1, 2025
White
adipose
tissue
is
in
charge
of
storing
excess
energy
form
lipids.
The
main
cells
involved
the
process
-
adipocytes
adapt
their
sizes
up
to
200μm
diameter
accomodate
storage.
In
addition,
size
distribution
bimodal.
A
previous
mathematical
model
based
on
lipid
fluxes
provided
bimodality.
However,
variability
within
cell
population
was
not
fully
explored.
model,
bimodality
considered
a
consequence
bistable
at
equilibrium:
meaning
that
had
have
two
stable
sizes.
this
study,
we
first
provide
computational
method
evaluate
equilbria
taking
into
account
variabilty.
Our
results
suggest
key
realistic
distributions.
show
with
proportion
bi-stable
profile
are
good
agreement
measurements.
We
find
mono-stable
(i.e.
one
equilibrium
size)
enough
explain
and
reproduces
qualitatively
data.
thus
does
arise
directly
from
cellular
bi-stability
but
rather
property.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3245 - 3245
Published: Sept. 25, 2024
Background:
Obesity
is
a
global
issue,
the
development
of
which
depends
on
many
interacting
factors.
Among
these,
hormones
secreted
in
gastrointestinal
tract
play
an
important
role.
The
aim
this
review
was
to
assess
impact
these
functions
adipose
tissue.
Methods:
analysis
based
latest
research
concerning
both
tissue
and
hormones.
Results:
It
found
that
can
significantly
affect
tissue,
directly
indirectly.
Some
hormones,
when
excess,
stimulate
formation
processes,
while
others
inhibit
them.
location
type
as
well
physiological
state
body.
should
also
be
noted
no
hormone
acts
isolation
but
close
cooperation
with
other
Conclusions:
relationship
between
their
role
obesity,
complex
evolving
field
study.
Further
necessary,
particularly
into
interactions
factors,
mutual
interactions.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 4, 2025
Abstract
This
landmark
propensity-score
matched
study
examined
ocular
outcomes
of
modern
anti-obesity
medications
in
nearly
5
million
non-diabetic
individuals
with
obesity.
Through
analysis
TriNetX
US
network
data,
we
discovered
that
Tirzepatide
significantly
reduced
cataract
risk
versus
other
treatments,
showing
a
striking
59%
lower
compared
to
Semaglutide
(HR:
0.41,
95%
CI:
0.19–0.85).
users
experienced
markedly
fewer
visual
disturbances
than
those
on
Contrave
0.58,
0.41–0.82)
or
Phentermine
0.62,
0.46–0.82).
Both
GLP-1
receptor
agonists
demonstrated
protection
against
age-related
cataracts,
exceptional
benefits
0.17,
0.07–0.42).
While
these
protective
effects
remained
robust
across
patient
subgroups,
Tirzepatide's
diminished
impaired
kidney
function.
Multiple
sensitivity
analyses
and
negative
controls
validated
compelling
findings.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 28, 2024
Tirzepatide,
a
novel
GLP-1/GIP
dual
receptor
agonist,
shows
significant
advantages
in
glycemic
management
and
weight
control.
By
summarizing
the
results
of
SURMOUNT
SURPASS
clinical
trials,
we
evaluate
efficacy
safety
tirzepatide
reducing
blood
glucose
weight.
These
trials
indicate
that
significantly
lowers
HbA1c
levels
(with
maximum
reduction
2.24%)
promotes
loss
(up
to
11.2
kg)
with
good
tolerability.
However,
there
are
still
some
challenges
its
application,
including
high
treatment
costs
gastrointestinal
discomfort.
Additionally,
special
populations,
such
as
patients
renal
impairment,
require
further
investigation.
Future
large-scale
SURPASS-CVOT
SUMMIT,
expected
verify
long-term
benefits
cardiovascular
health
management,
providing
stronger
evidence
for
comprehensive
diabetes
complications.
Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Abstract
Obesity
and
type
2
diabetes
are
significant
public
health
challenges
that
greatly
impact
global
well‐being.
The
development
of
effective
therapeutic
strategies
has
become
more
concentrated
on
the
central
nervous
system
metabolic
regulation.
primary
pharmaceutical
interventions
for
treatment
obesity
uncontrolled
hyperglycemia
now
generally
considered
to
be
incretin‐based
anti‐diabetic
treatments,
particularly
glucagon‐like
peptide‐1
glucose‐dependent
insulinotropic
polypeptide
receptor
agonists.
This
is
a
result
their
substantial
influence
consequent
effects
energy
balance
glucose
It
increasingly
crucial
understand
neural
pathways
these
pharmaceuticals.
purpose
this
review
compile
present
most
recent
regarding
peptide‐1,
glucagon
receptors,
with
particular
emphasis
