Antimicrobial Nanofibers to Fight Multidrug-Resistant Bacteria DOI
Carolina A. M. Ferreira, Sara F. C. Guerreiro, Tatiana Padrão

et al.

Published: Jan. 1, 2024

Multidrug-resistant bacteria are among the most challenges in healthcare systems. According to World Health Organization, these that belong critical and high-priority groups resistant carbapenem or multiple antibiotics, respectively. They commonly associated with bone, skin, soft tissue infections, current treatment strategies involve use of oral intravenous antibiotics. Consequently, infected injured sites benefit from combined antimicrobial regenerative action during tissues' repair. The high demand for effective solutions led development biocompatible antibacterial polymeric membranes local therapy. These highly porous composed by nanofibers' network providing a matrix cellular proliferation release agents. Nowadays, there several techniques produce nanofibers like template synthesis, self-assembly, freeze-drying, melt-blowing, electrospinning, others. Electrospinning emerges production intrinsic characteristics. surface area-to-volume ratio nanometric diameters allow mimicking innate tissues increasing biomedical fields' attention. Therefore, electrospun become favoured as drug delivery systems, improving drugs' dissolution rates while maximizing their action. Additionally, they permits loading drugs higher concentrations control rate without toxicity. Hence, antibiotics have been common encapsulated medicinal compounds using numerous polymers combinations carriers. versatility electrospinning advanced approaches which combine complex locally provide agents through same platform consider different profiles. Overall, further developments should continue systems meet clinical requirements.

Language: Английский

The Bioavailability of Drugs—The Current State of Knowledge DOI Creative Commons

Marlena Stielow,

Adrianna Witczyńska,

Natalia Kubryń

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8038 - 8038

Published: Dec. 11, 2023

Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness drug therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in patients' bodies essential to ensure proper safe treatment. This publication aims highlight relevance research its importance In addition biochemical activity, also plays critical role achieving desired therapeutic effects. may seem obvious, but it worth noting that can only produce expected effect if level concentration be achieved at point patient's body. Given differences between patients, dosages, administration forms, understanding controlling has become priority pharmacology. discusses basic concepts factors it. We looked various methods assessing bioavailability, both laboratory clinic. Notably, introduction new technologies tools this field vital achieve advances research. cases with poorly described providing deeper complex challenges they pose medical researchers practitioners. Simultaneously, article focuses on perspectives trends shape future regarding which development modern pharmacology context, offers an essential, meaningful contribution toward highlighting bioavailability's reliable patient The text identifies areas require further exploration.

Language: Английский

Citations

123

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action DOI Creative Commons
Massimo Sartelli, Philip S. Barie, Federico Coccolini

et al.

World Journal of Emergency Surgery, Journal Year: 2023, Volume and Issue: 18(1)

Published: Oct. 16, 2023

Abstract Antibiotics are recognized widely for their benefits when used appropriately. However, they often inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component universal healthcare, and it a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive develop new antibiotics due scientific, regulatory, financial barriers, further emphasizing To address this issue, Global Alliance Infections in Surgery established international multidisciplinary task force 295 experts from 115 countries with different backgrounds. The developed position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness antimicrobial resistance improving prescribing practices worldwide. outlined 10 axioms, or “golden rules,” that all healthcare workers should consistently adhere

Language: Английский

Citations

44

Early switch from intravenous to oral antibiotic treatment in bone and joint infections DOI Creative Commons
Parham Sendi,

Jaime Lora-Tamayo,

Nicolás W Cortés-Penfield

et al.

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 29(9), P. 1133 - 1138

Published: May 12, 2023

Language: Английский

Citations

17

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial DOI Creative Commons
Ali S. Omrani,

Sulieman H. Abujarir,

Fatma Ben Abid

et al.

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 30(4), P. 492 - 498

Published: Oct. 18, 2023

To evaluate the safety and efficacy of switching from intravenous (IV) to oral antimicrobial therapy in patients with Enterobacterales bacteraemia, after completion 3-5 days microbiologically active IV therapy.

Language: Английский

Citations

16

Bone Voyage: Navigating Updates in the Management of Bone and Joint Infections DOI
Barbara A. Santevecchi,

Kayihura Manigaba,

Lindsey M. Childs‐Kean

et al.

Current Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 2, 2025

Language: Английский

Citations

0

Unveiling the trending paradigms of synthesis and theranostic biomedical potentials of nano-diamonds (NDs) DOI Creative Commons
Sagnik Nag,

Kedlaya Srikrishna H. Damodar,

Suprabhat Mukherjee

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114313 - 114313

Published: March 1, 2025

Language: Английский

Citations

0

“Once more, with feeling”: no difference in outcomes between patients discharged on oral versus intravenous antibiotics for orthopedic infections in a propensity score matched cohort at a US medical center DOI Creative Commons
Julie Gray, Russell J Benefield, Chanah K. Gallagher

et al.

Antimicrobial Stewardship & Healthcare Epidemiology, Journal Year: 2024, Volume and Issue: 4(1)

Published: Jan. 1, 2024

To compare outcomes between patients discharged on intravenous (IV) versus oral (PO) antibiotics for the treatment of orthopedic infections, after creation an IV-to-PO guideline, at a single academic medical center in United States.

Language: Английский

Citations

2

Oral switch vs continued intravenous antibiotic therapy in patients with bacteraemia and sepsis: a systematic review and meta-analysis DOI
Qinyuan Li, Qi Zhou,

Junqiao Fan

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2

Antibiotic Guideline Adherence at the Emergency Department: A Descriptive Study from a Country with a Restrictive Antibiotic Policy DOI Creative Commons
Mariana Bichuette Cartuliares, Sara N. Søgaard, Flemming Schønning Rosenvinge

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(12), P. 1680 - 1680

Published: Nov. 29, 2023

Denmark has a low level of antimicrobial resistance (AMR). Patients hospitalized with suspected infection often present unspecific symptoms. This challenges the physician between using narrow-spectrum antibiotics in accordance guidelines or broad-spectrum to compensate for diagnostic uncertainty. The aim this study was investigate adherence restrictive antibiotic guideline most common emergency departments (EDs), namely community-acquired pneumonia (CAP).This multicenter descriptive cross-sectional included adults admitted Danish EDs infection. Data were collected prospectively from medical records.We 954 patients analysis. prescribed penicillin beta-lactamase inhibitor at 4 h (307 (32.2%)), 48 (289 (30.3%)), and day 5 after admission (218 (22.9%)). empirical treatment CAP followed 126 (31.3%) patients. At h, administered intravenously 244 (60.7%) 5, 218 (54.4%) received oral antibiotics.Adherence poor. In country policy, infections are commonly treated against recommendations.

Language: Английский

Citations

3

Early switch from intravenous to oral anti-microbial therapy in infectious diseases DOI Creative Commons
Parham Sendi, Sandra B. Nelson, Àlex Soriano

et al.

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 29(9), P. 1117 - 1119

Published: June 21, 2023

Language: Английский

Citations

2