Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107691 - 107691
Published: May 1, 2025
Language: Английский
Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 38 - 38
Published: Jan. 6, 2025
Antimicrobial resistance (AMR) represents a critical threat to human, animal, and environmental health, challenging global efforts maintain sustainable ecosystems public health systems. In this review, the complex, cross-disciplinary issues of AMR are explored within framework planetary emphasizing interconnectedness human veterinary medicine with broader social Specifically, it addresses social, economic, environmental, dimensions under framework. The aspects consider how awareness, education, healthcare practices shape antimicrobial use (AMU) patterns. economic impact evaluates cost burdens AMR, including costs, loss productivity, implications for livestock food production industries. dimension highlights role pharmaceutical waste, agricultural runoff, industrial pollution in contributing spread antimicrobials resistant pathogens ecosystems. To illustrate these challenges, comprehensive literature review using PubMed Web Science databases was conducted, identifying 91 relevant articles on AMR. knowledge from studies additional references is integrated provide holistic overview crisis. By applying four pillars health-social, knowledge-in manuscript, necessity underscored collaborative strategies across combat Ultimately, synergistic approach aims policies that safeguard protect ecosystems, promote future by implementing stewardship programs encouraging prudent AMU.
Language: Английский
Citations
3
JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(2)
Published: March 5, 2024
Antimicrobial resistance (AMR) is a global public health crisis. This study assessed the general public's consumption of antibiotics and associated factors in Lusaka district Zambia.
Language: Английский
Citations
15
Antibiotics, Journal Year: 2024, Volume and Issue: 13(1), P. 100 - 100
Published: Jan. 19, 2024
In the multimodal strategy context, to implement healthcare-associated infection prevention, bundles are one of most commonly used methods adapt guidelines in local context and transfer best practices into routine clinical care. One important measures prevent surgical site infections is antibiotic prophylaxis (SAP). This narrative review aims present a bundle for correct SAP administration evaluate evidence supporting it. Surgical (SSI) prevention published by WHO, CDC, NICE, SHEA/IDSA/APIC/AHA, practice ASHP/IDSA/SIS/SHEA, were reviewed. Subsequently, comprehensive searches also conducted using PubMed®/MEDLINE Google Scholar databases, order identify further evidence-based documentation. The includes five different that may affect proper administration. included be easily implemented all hospitals worldwide based on minimal drug pharmacokinetics pharmacodynamics knowledge, which surgeons should know. Antibiotics prescribed procedures at high risk SSIs, such as clean–contaminated contaminated or clean where even if unlikely, have devastating consequences, with prosthetic implants. generally administered within 60 min before incision antibiotics (including cefazolin). redosing indicated exceeding two half-lives significantly associated blood loss. principle, discontinued after procedure. Hospital-based antimicrobial stewardship programmes can optimise treatment reduce adverse events antibiotics. collaborative interdisciplinary approach, it essential encourage an institutional safety culture persuaded, rather than compelled, respect prescribing practices. proposed contains set interventions It easy apply, promotes collaboration, adequately followed evaluated worldwide.
Language: Английский
Citations
13
JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(3)
Published: May 6, 2024
Antimicrobial resistance (AMR) poses a threat to public health globally. Despite its consequences, there is little information about the knowledge, awareness, and practices towards AMR among healthcare workers (HCWs). Therefore, this study assessed awareness regarding antimicrobial use (AMU), stewardship (AMS) HCWs who are involved in implementation of AMS activities across eight hospitals Zambia.
Language: Английский
Citations
13
JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(2)
Published: March 5, 2024
Abstract Background The overuse and misuse of antimicrobials has worsened the problem antimicrobial resistance (AMR) globally. This study investigated AMR profiles Escherichia coli isolated from clinical environmental samples in Lusaka, Zambia. Methods was a cross-sectional conducted February 2023 to June using 450 samples. VITEK® 2 Compact used identify E. perform susceptibility testing. Data analysis done WHONET 2022 SPSS version 25.0. Results Of samples, 66.7% (n = 300) were whereas 33.3% 150) Overall, 47.8% 215) (37.8% 10% environmental) tested positive for coli. 215 isolates, 66.5% MDR 42.8% ESBL-producers. Most isolates resistant ampicillin (81.4%), sulfamethoxazole/trimethoprim (70.7%), ciprofloxacin (67.9%), levofloxacin (64.6%), ceftriaxone (62.3%) cefuroxime (62%). Intriguingly, highly susceptible amikacin (100%), imipenem (99.5%), nitrofurantoin (89.3%), ceftolozane/tazobactam (82%) gentamicin (72.1%). Conclusions found high some antibiotics that are commonly humans. isolation ESBL-producing is public health concern requires urgent action. Therefore, there need instigate strengthen interventional strategies including stewardship programmes combat
Language: Английский
Citations
10
BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 27, 2025
The dispensing of non-prescription antibiotics is a worldwide concern, and should only be dispensed with legitimate prescription. A cross-sectional study was conducted using the simulated client methodology, data collected, recorded, analyzed SPSS. visited 210 pharmacies, which 70 without Outcomes most often suggested for upper respiratory tract infections (URTIs) were Amoxicillin (n = 17, 8.1%), Clarithromycin 20, 9.5%), Moxifloxacin 13, 6.2%), 33.3% medications prescription URTIs. Cefixime 9.5%) ceftriaxone 8.1%) administered urinary (UTIs). non-prescribed (UTIs) markedly elevated (p < 0.05). Antibiotics diarrheal diseases in over 50% Metronidazole 23, 11%), Azithromycin 16, 7.6%), Rifaximin 15, 7.1%) being prescribed. In all bivariate multivariate models, male gender associated reduced likelihood (COR: 0.30, 95% CI: 0.12–0.72; p 0.0079 AOR: 0.03, 0.005–0.15; 0.0001). Individuals aged 30 years older exhibited increased odds both 3.67, 1.69–8.87; 0.0018) analyses (AOR: 9.44, 2.55–61.70; 0.001). presence pharmacist on duty diminished administering 0.13, 0.06–0.25; 0.001; 0.06, 0.03–0.16; These findings highlight imperative enforcing existing laws implementing rigorous rules, alongside pharmacy-centered antimicrobial stewardship programs that focus accurate practices to mitigate resistance.
Language: Английский
Citations
2
Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
2
Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 256 - 256
Published: March 2, 2025
Background/Objectives: Artificial intelligence has made significant strides in healthcare, contributing to diagnosing, treating, monitoring, preventing, and testing various diseases. Despite its broad adoption, clinical consensus on AI’s role infection control remains uncertain. This scoping review aims understand the characteristics of AI applications bacterial control. Results: examines control, analyzing 54 eligible studies across 5 thematic scopes. The search from 3 databases yielded a total 1165 articles, only articles met eligibility criteria were extracted analyzed. Five scopes synthesized data; countries, aim, type AI, advantages, limitations prevention majority reported high-income mainly by USA. most common are pathogen identification risk assessment. used is machine learning. commonest advantage predictive modeling assessment, disadvantage generalizability models. Methods: was developed according Arksey O’Malley frameworks. A comprehensive PubMed, Embase, Web Science conducted using terms, with no restrictions. Publications focusing included. Citations managed via EndNote, initial title abstract screening two authors. Data underwent narrative mapping categorization, followed construction Conclusions: need be strengthened for low-income countries. More efforts should dedicated investing models that have proven their effectiveness maximize utilization tackle challenges.
Language: Английский
Citations
1
Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 896 - 896
Published: Sept. 20, 2024
Antimicrobial resistance (AMR) is one of the main public health global burdens 21st century, responsible for over a million deaths every year. Hospital programs aimed at improving antibiotic use, referred to as antimicrobial stewardship (ASPs), can both optimize treatment infections and minimize adverse antibiotics events including development spread AMR. The challenge AMR closely linked healthcare-associated infection (HAIs). In fact, management patients with HAIs frequently requires administration broader-spectrum regimens due higher risk acquiring multidrug-resistant organisms, which, in turn, promotes resistance. For this reason, even before using correctly, it necessary prevent control our hospitals. narrative review, we present seven measures that healthcare workers, if not directly involved tasks prevention control, must know, support, embrace. We hope review may raise awareness among all professionals about issues increasing rate ongoing efforts towards minimizing its rise.
Language: Английский
Citations
7
Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 887 - 902
Published: Feb. 1, 2025
The inappropriate prescribing and use of antibiotics have contributed to the emergence spread antimicrobial resistance (AMR). In Zambia, there is a paucity information on patterns among hospitalized patients in level 1 hospitals. This study investigated antibiotic five hospitals Lusaka, Zambia. cross-sectional utilized World Health Organization (WHO) Point Prevalence Survey (PPS) methodology in-patients admitted before 08:00 a.m. survey day August 2024. Data were analysed using IBM SPSS version 23.0. prevalence inpatients was 59.0%, with ceftriaxone being most prescribed. Antibiotics prescribed mainly for paediatrics male inpatients. found that 53.0% from Access group while 38.2% Watch Access, Watch, Reserve (AWaRe) classification. Adherence national treatment guidelines 36.0%, empirically without evidence culture sensitivity tests. high low adherence findings this demonstrate need establish strengthen stewardship programs laboratory capacity aid clinicians diagnosing, treating, managing across
Language: Английский
Citations
1