Which trial do we need? A randomized controlled trial comparing oral antibiotic monotherapy versus standard of care as antibiotic continuation treatment for the treatment of left-sided native valve bacterial endocarditis. DOI
Johan Van Laethem

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Osteomyelitis DOI Open Access
Myriam Jean Cadet

Nursing, Journal Year: 2025, Volume and Issue: 55(3), P. 28 - 35

Published: Feb. 21, 2025

Abstract: Osteomyelitis is characterized by inflammation of the bone tissue, typically caused microorganisms such as bacteria. It can be challenging to treat and may lead unnecessary antibiotic therapies. Prompt identification osteomyelitis implementation effective treatments are necessary eradicate this infection. This article discusses pathophysiology, clinical presentation, diagnosis, nursing management osteomyelitis, focusing on native

Language: Английский

Citations

0

Comparative study of the inhibitory effects of different antibiotic administration routes on bone healing in a rat tibial infection model DOI Creative Commons
Xianlin Han, Wei Wang,

Zixian Shen

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 28, 2025

Objective This study aimed to evaluate the effectiveness of intravenous versus oral antibiotic treatments in managing bone infections, particularly osteomyelitis, using a rat tibial infection model. Methods A model was established twelve-week-old Wistar rats via injection Staphylococcus aureus at cortical defect site. After six weeks, were treated with vancomycin (intravenous), cefazolin ciprofloxacin (oral), or combined rifampin (oral). Microbial analysis, blood analysis for pro-inflammatory cytokines, micro-computed tomography (μCT), histological and osteoclast activity used assess efficacy each treatment. Results Blood showed significant reductions white cell count cytokines treatment groups, especially vancomycin. μCT imaging revealed better preservation structure while resulted more pronounced structural deterioration. confirmed lower bacterial load vancomycin, compared treatments. Histological reduced inflammation, fibrosis, minimal presence groups. Osteoclast notably indicating control resorption. Conclusion Intravenous administration demonstrated superior controlling infection, reducing preserving While ciprofloxacin-rifampin combination some efficacy, they less effective than likely due bioavailability insufficient drug penetration tissue.

Language: Английский

Citations

0

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis DOI Creative Commons
Dong Yang, Chang Shu, Chengwei Xu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way

Language: Английский

Citations

0

Optimizing Antibiotic Therapy in Musculoskeletal Infections DOI
Nicolás W Cortés-Penfield, Julie Ann Justo,

Erin K McCreary

et al.

Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0

Oral versus intravenous antibiotics for bone and joint infections: Systematic review and meta-analysis of randomized controlled trials DOI

J. Lima,

Kauê A Chagas,

Lívia Fernanda de Oliveira

et al.

Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117494 - 117494

Published: April 1, 2025

Language: Английский

Citations

0

Research Progress in Medical Biomaterials for Bone Infections DOI Creative Commons
Tingting Lian,

Yiwei Wang,

Pengfei Zheng

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 189 - 189

Published: May 21, 2025

Bone infection is a debilitating condition characterized by inflammation of the bone and its marrow. It poses significant challenges in clinical practice due to recalcitrant nature difficulty eradicating infecting microorganisms. Recent advancements field medical biomaterials have shown hope treatment infections. This article reviews research progress for anti-osteomyelitis recent years, focusing on mechanism action, unique advantages, application backgrounds various materials. At same time, we pay attention need materials used osteomyelitis promote healing.

Language: Английский

Citations

0

Periprosthetic Joint Infections DOI
Angela Hewlett, Beau J. Kildow, Nicolás W Cortés-Penfield

et al.

Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0

Factors influencing the use of highly bioavailable oral antibiotic therapy for the treatment of prosthetic joint infections DOI Creative Commons

Marie-Félixe Granger,

Jerome A. Leis, Amanda Hempel

et al.

Infection Control and Hospital Epidemiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 4

Published: Oct. 10, 2024

We conducted a retrospective cohort study to identify factors influencing intravenous (IV) versus oral antibiotic therapy in first-episode prosthetic joint infections. Of the 34/78 (44%) cases treated intravenously, negative cultures (26%), concomitant infections necessitating IV antibiotics (21%), and delays susceptibility testing (15%) were most common reasons for therapy.

Language: Английский

Citations

2

Methicillin Resistance Increased the Risk of Treatment Failure in Native Joint Septic Arthritis Caused by Staphylococcus aureus DOI Creative Commons
Jungok Kim, So Yeon Park, Kyung Mok Sohn

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1628 - 1628

Published: Nov. 15, 2023

This study aimed to compare clinical characteristics and outcomes in patients with native joint septic arthritis (NJSA) due methicillin-resistant Staphylococcus aureus (MRSA) comparison methicillin-sensitive S. (MSSA) identify treatment failure risk factors. We conducted a multi-center retrospective on adult NJSA at three teaching hospitals South Korea from 2005 2017. Among 101 diagnosed NJSA, 39 (38.6%) had MRSA strains. Compared MSSA, higher prevalence of nosocomial infections (17.9% vs. 1.6%; p = 0.005) received inappropriate antibiotics within 48 h more frequently (74.4% 0%; < 0.001). In total, twenty (19.8%) experienced failure, which encompassed five (5.0%) who passed away, nine (8.9%) requiring repeated surgical drainage after 30 days antibiotic therapy, seven (6.9%) relapse. The group showed rate overall (33.3% 11.3%; 0.007) notably increased frequency interventions therapy 3.2%, 0.026), contrast the MSSA group. Independent factors for included Charlson comorbidity score, elevated CRP levels, methicillin resistance. Methicillin resistance is an independent factor emphasizing need vigilant monitoring targeted MRSA-related cases.

Language: Английский

Citations

4

Clinical, organizational, and pharmacoeconomic perspectives of dalbavancin vs standard of care in the infectious disease network DOI Creative Commons
Daniela Segala, Marco Barbieri,

Mariachiara Di Nuzzo

et al.

Global & Regional Health Technology Assessment, Journal Year: 2024, Volume and Issue: 11(Suppl. 2), P. 5 - 12

Published: July 29, 2024

The therapeutic approach to the patient with acute bacterial skin and structure infection (ABSSSI) complicated infections often involves early transition from intravenous oral therapy (early switch) or discharge. Our study aimed evaluate sustainable innovative care models that can be transferred community healthcare economic impact of dalbavancin vs Standard Care (SoC) for treatment ABSSSI other Gram-positive including those by multidrug-resistant organisms. We also described organization an infectious disease network allows optimizing complex dalbavancin.

Language: Английский

Citations

1