Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Nursing, Journal Year: 2025, Volume and Issue: 55(3), P. 28 - 35
Published: Feb. 21, 2025
Abstract: Osteomyelitis is characterized by inflammation of the bone tissue, typically caused microorganisms such as bacteria. It can be challenging to treat and may lead unnecessary antibiotic therapies. Prompt identification osteomyelitis implementation effective treatments are necessary eradicate this infection. This article discusses pathophysiology, clinical presentation, diagnosis, nursing management osteomyelitis, focusing on native
Language: Английский
Citations
0Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 28, 2025
Objective This study aimed to evaluate the effectiveness of intravenous versus oral antibiotic treatments in managing bone infections, particularly osteomyelitis, using a rat tibial infection model. Methods A model was established twelve-week-old Wistar rats via injection Staphylococcus aureus at cortical defect site. After six weeks, were treated with vancomycin (intravenous), cefazolin ciprofloxacin (oral), or combined rifampin (oral). Microbial analysis, blood analysis for pro-inflammatory cytokines, micro-computed tomography (μCT), histological and osteoclast activity used assess efficacy each treatment. Results Blood showed significant reductions white cell count cytokines treatment groups, especially vancomycin. μCT imaging revealed better preservation structure while resulted more pronounced structural deterioration. confirmed lower bacterial load vancomycin, compared treatments. Histological reduced inflammation, fibrosis, minimal presence groups. Osteoclast notably indicating control resorption. Conclusion Intravenous administration demonstrated superior controlling infection, reducing preserving While ciprofloxacin-rifampin combination some efficacy, they less effective than likely due bioavailability insufficient drug penetration tissue.
Language: Английский
Citations
0Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way
Language: Английский
Citations
0Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117494 - 117494
Published: April 1, 2025
Language: Английский
Citations
0Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 189 - 189
Published: May 21, 2025
Bone infection is a debilitating condition characterized by inflammation of the bone and its marrow. It poses significant challenges in clinical practice due to recalcitrant nature difficulty eradicating infecting microorganisms. Recent advancements field medical biomaterials have shown hope treatment infections. This article reviews research progress for anti-osteomyelitis recent years, focusing on mechanism action, unique advantages, application backgrounds various materials. At same time, we pay attention need materials used osteomyelitis promote healing.
Language: Английский
Citations
0Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0Infection Control and Hospital Epidemiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 4
Published: Oct. 10, 2024
We conducted a retrospective cohort study to identify factors influencing intravenous (IV) versus oral antibiotic therapy in first-episode prosthetic joint infections. Of the 34/78 (44%) cases treated intravenously, negative cultures (26%), concomitant infections necessitating IV antibiotics (21%), and delays susceptibility testing (15%) were most common reasons for therapy.
Language: Английский
Citations
2Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1628 - 1628
Published: Nov. 15, 2023
This study aimed to compare clinical characteristics and outcomes in patients with native joint septic arthritis (NJSA) due methicillin-resistant Staphylococcus aureus (MRSA) comparison methicillin-sensitive S. (MSSA) identify treatment failure risk factors. We conducted a multi-center retrospective on adult NJSA at three teaching hospitals South Korea from 2005 2017. Among 101 diagnosed NJSA, 39 (38.6%) had MRSA strains. Compared MSSA, higher prevalence of nosocomial infections (17.9% vs. 1.6%; p = 0.005) received inappropriate antibiotics within 48 h more frequently (74.4% 0%; < 0.001). In total, twenty (19.8%) experienced failure, which encompassed five (5.0%) who passed away, nine (8.9%) requiring repeated surgical drainage after 30 days antibiotic therapy, seven (6.9%) relapse. The group showed rate overall (33.3% 11.3%; 0.007) notably increased frequency interventions therapy 3.2%, 0.026), contrast the MSSA group. Independent factors for included Charlson comorbidity score, elevated CRP levels, methicillin resistance. Methicillin resistance is an independent factor emphasizing need vigilant monitoring targeted MRSA-related cases.
Language: Английский
Citations
4Global & Regional Health Technology Assessment, Journal Year: 2024, Volume and Issue: 11(Suppl. 2), P. 5 - 12
Published: July 29, 2024
The therapeutic approach to the patient with acute bacterial skin and structure infection (ABSSSI) complicated infections often involves early transition from intravenous oral therapy (early switch) or discharge. Our study aimed evaluate sustainable innovative care models that can be transferred community healthcare economic impact of dalbavancin vs Standard Care (SoC) for treatment ABSSSI other Gram-positive including those by multidrug-resistant organisms. We also described organization an infectious disease network allows optimizing complex dalbavancin.
Language: Английский
Citations
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