Current Biology, Journal Year: 2021, Volume and Issue: 31(24), P. R1555 - R1557
Published: Dec. 1, 2021
Language: Английский
Current Opinion in Behavioral Sciences, Journal Year: 2022, Volume and Issue: 48, P. 101226 - 101226
Published: Oct. 7, 2022
Food rewards elicit a variety of affective responses. They emerge from multiple components, including motivational and hedonic processes. Here, we review evidence for these components through an science lens. We describe recent advances showing that the are modulated by dopamine opioids in different ways, involve distinct subregions ventral striatum, decoupled addiction. Building on conceptual links between food-reward appraisal processes emotion, propose multicomponential framework distinguishing elicitation- response-based affective-reward suggest relevance could be key determinant elicitation food-seeking behaviors. outline how this can help identify psychological neural implicated responses relying properties food examine effects executive control thereon. Altogether, approach to may contribute better mechanistic understanding eating behaviors valuation food.
Language: Английский
Citations
12
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 27, 2024
Abstract Background Anhedonia is a core symptom of major depressive disorder (MDD). While its narrow definition as hedonic or consummatory deficit evolved to encompass anticipatory and motivational reward facets, it remains unclear where deficits manifest. As evidence accumulates for metabolic hormones affecting processing, studying their role in mitigating could yield crucial insights. Here, we compare food ratings between patients with MDD healthy control participants (HCPs) from anticipation consummation evaluate associations anhedonia parameters. Methods We conducted cross-sectional study 103 participants, including 52 51 HCPs. After overnight fasting, blood samples were collected determine levels ghrelin, glucose, insulin, triglycerides. Participants completed taste test, providing repeated wanting liking, gradually moving consummation. Findings Patients showed decreased ( p = .046) but not liking rewards during visual anticipation. However, once was inspected tasted, increased relative HCPs .004), strong against (Bayes Factors > 9). In contrast anhedonia, higher scores on the Snaith-Hamilton Pleasure Scale associated reduced .010) more pronounced increases proximity .037). Acyl ghrelin ratings, while poor glycemic linked symptoms anhedonia. Interpretation Our demonstrates that are rather than pleasure deficits. Notably, ghrelin’s association elevated implicates gut-brain axis potential target treating MDD. Funding DFG KR 4555/7-1, 4555/9-1, 4555/10-1, & WA 2673/15-1 Graphical Research context Evidence before this Anhedonia, depression, has traditionally been conceptualised pleasure. recent definitions have expanded include aspects processing. Despite evolution, experimental studies systematically investigate these facets lacking, most animal models focusing Added value This contributes novel insights by demonstrating Major Depressive Disorder (MDD) exhibit rewards. Bayesian hypothesis testing indicates deficit, suggesting instead primary impairment Additionally, highlights peripheral specific function, shedding light underlying mechanisms lower insulin sensitivity glucose fasting acyl ratings. Implications all available The findings suggest wanting, pleasure, may underlie distinction important implications treatment strategies, targeting incentive motivation be effective alleviating symptoms. observation improves therapeutic approach enhancing proximity. Furthermore, suggests signalling symptoms, particularly cases depression involving loss appetite weight.
Language: Английский
Citations
2
Published: Sept. 7, 2023
The phenomenon of aesthetic chills—shivers and goosebumps associated with either rewarding or threatening stimuli—offers a unique window into the brain basis conscious reward due to their universal nature simultaneous subjective physical counterparts. Elucidating neural mechanisms underlying chills can reveal fundamental insights about emotion, consciousness, embodied mind. What is precise timing mechanism bodily feedback in emotional experience? How are feelings motivations generated from interoceptive predictions? role uncertainty precision signaling shaping emotions? does distinguish balance processing rewards versus threats? Here we review neuroimaging evidence highlight key questions for understanding how sensations shape pleasure meaning. This research stands advance models brain-body interactions affect may lead novel non-pharmacological interventions disorders motivation pleasure.
Language: Английский
Citations
6
Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(6), P. 1111 - 1124
Published: May 4, 2024
Abstract Rationale Evidence on the effect of dopamine D1-like and D2-like receptor antagonists licking microstructure forced swimming response led us to suggest that (i) receptors plays a role in activating reward-directed responses (ii) level activation is reboosted based process evaluation efficacy requiring receptors. A main piece evidence support this hypothesis observation antagonist raclopride induces within-session decrement burst number occurring after contact with reward. The few published studies detailed analysis time-course measure were conducted our laboratory. Objectives aim review recapitulate discuss as behavioural substrate for study mechanisms governing ingestion, related processes, its relevance drug effects ingestion. Conclusions gathered so far suggests provides an important might provide decisive drugs However, further from independent sources necessary validate use proposed interpretation measure.
Language: Английский
Citations
2
Current Biology, Journal Year: 2021, Volume and Issue: 31(24), P. R1555 - R1557
Published: Dec. 1, 2021
Language: Английский
Citations
13