Synlett,
Journal Year:
2023,
Volume and Issue:
35(14), P. 1629 - 1647
Published: Oct. 13, 2023
Abstract
This
account
summarizes
the
impact
that
quest
for
sustainability
is
having
on
field
of
organic
polyconjugate
molecules
and
polymers
plastic
(opto)electronics.
While
at
proof-of-concept
level,
design
criteria
as
well
preferred
synthetic
strategies
to
access
new
improved
materials
have
been
dominated
by
need
performance.
The
ongoing
transition
from
lab
environment
industrial
scale
imposes
strict
limitations
cost
overall
environmental
materials.
We
here
summarize
our
efforts
development
aimed
improving
–
without
compromising
performance
in
polyconjugated
molecules.
article
composed
three
sections:
Introduction
motivation,
through
methods
design.
Outline
1
Motivation
2
Sustainable
Reaction
Methods
2.1
New
Tools:
Reactions
Aqueous
Solution
Surfactants
2.2
Intrinsically
More
Reactions:
Direct
Arylation
2.3
Multistep
Protocols:
Combining
Micellar,
Solventless,
Mechanochemical
3
Sustainability
a
Design
Criterion:
De
Novo
4
Conclusion
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(2), P. 301 - 317
Published: Jan. 16, 2024
Water
is
considered
to
be
the
most
sustainable
and
safest
solvent.
Micellar
catalysis
a
significant
contributor
chemistry
in
water.
It
promotes
pathways
involving
water-sensitive
intermediates
transient
catalytic
species
under
micelles'
shielding
effect
while
also
replacing
costly
ligands
dipolar-aprotic
solvents.
However,
there
lack
of
critical
information
about
micellar
catalysis.
This
includes
why
it
works
better
than
traditional
organic
solvents,
specific
rules
differ
from
those
conventional
catalysis,
how
limitations
can
addressed
future.
Perspective
aims
highlight
current
gaps
our
understanding
provide
an
analysis
designer
surfactants'
origin
essential
components.
will
fundamental
including
aqueous
micelles
simultaneously
perform
multiple
functions
such
as
solvent,
ligand,
reaction
promoter.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(12), P. 4809 - 4809
Published: June 16, 2023
Many
years
ago,
twelve
principles
were
defined
for
carrying
out
chemical
reactions
and
processes
from
a
green
chemistry
perspective.
It
is
everyone’s
endeavor
to
take
these
points
into
account
as
far
possible
when
developing
new
or
improving
existing
ones.
Especially
in
the
field
of
organic
synthesis,
area
research
has
thus
been
established:
micellar
catalysis.
This
review
article
addresses
question
whether
catalysis
by
applying
reaction
media.
The
shows
that
many
can
be
transferred
an
solvent
medium,
but
surfactant
also
crucial
role
solubilizer.
Thus,
carried
much
more
environmentally
friendly
manner
with
less
risk.
Moreover,
surfactants
are
being
reformulated
their
design,
degradation
add
extra
advantages
match
all
chemistry.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 816 - 830
Published: March 14, 2024
From
the
context
of
sustainability,
contemporary
synthetic
organic
chemistry
practices
require
significant
transformation,
as
indicated
by
various
sustainability
matrices
like
atom
economy,
process
mass
intensity
(PMI),
E-factor,
and
DOZN.
These
factors
have
evidently
unveiled
inherent
inefficiencies
intrinsic
to
conventional
protocols
identified
solvents
principal
causative
agent.
In
response,
utilization
water
a
primary
reaction
medium
for
transformations
has
emerged
an
appealing
alternative.
This
approach
flourished
with
emergence
micellar
catalysis,
where
amphiphilic
molecules
alter
bulk
aqueous
medium's
solvation
properties
promote
desired
chemical
transformation
under
milder
sustainable
conditions.
After
2010,
this
technology
gained
considerable
momentum
established
foundational
framework
performing
reactions
conditions,
consequently
mitigating
dependency
on
hazardous
solvents.
perspective,
recent
advances
in
field
catalysis
will
be
discussed
industrial
applications,
along
future
directions
challenges
associated
regime.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 978 - 1002
Published: March 15, 2024
Despite
the
reported
successes
and
advantages
involving
use
of
amphiphilic
surfactants,
most
notably
TPGS-750-M,
to
enable
a
multitude
synthetic
transformations
be
conducted
in
water,
implementation
this
methodology
within
pharmaceutical
industry
has
been
relatively
limited.
In
paper,
we
will
disclose
key
results
learnings
from
multicompany
collaboration
focused
on
reproducibility
study
some
commonly
used
reaction
types
industry,
specifically
amidation,
SNAr,
nitro
reduction,
reductive
amination,
multiple
Pd-catalyzed
water.
The
presentation
not
just
originally
TPGS-750-M
conditions
but
also
under
water-only
control
with
three
different
as
well
both
small
(i.e.,
≤500
mg)
mid
(∼10
g)
scales.
Phase-separated
compartments
can
localize
(bio)chemical
reactions
and
influence
their
kinetics.
They
are
believed
to
play
an
important
role
both
in
extant
life
the
form
of
biomolecular
condensates
at
origins
as
coacervate
protocells.
However,
experimentally
testing
coacervates
on
different
is
practically
impossible.
We
therefore
use
a
numerical
model
explore
effect
phase-separated
droplets
kinetics
outcome
chemical
reaction
systems,
where
we
vary
volume
partitioning
reactants.
find
that
rate
bimolecular
has
optimal
dilute/coacervate
phase
ratio
for
given
reactant
partitioning.
Furthermore,
accelerate
polymerization
self-replication
lead
formation
longer
polymers.
Lastly,
‘rescue’
oscillating
networks
concentration
regimes
sustained
oscillations
do
not
occur
single-phase
system.
Our
results
indicate
direct
wide
range
impact
fundamental
aspects
such
yield,
pathway
selection,
product
length
emergent
functions.
This
may
have
far-reaching
implications
life,
synthetic
cells
fate
function
biological
condensates.
ChemSystemsChem,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Aug. 22, 2024
Abstract
Phase‐separated
compartments
can
localize
(bio)chemical
reactions
and
influence
their
kinetics.
They
are
believed
to
play
an
important
role
both
in
extant
life
the
form
of
biomolecular
condensates
at
origins
as
coacervate
protocells.
However,
experimentally
testing
coacervates
on
different
is
challenging
time‐consuming.
We
therefore
use
a
numerical
model
explore
effect
phase‐separated
droplets
kinetics
outcome
chemical
reaction
systems,
where
we
vary
volume
partitioning
reactants.
find
that
rate
bimolecular
has
optimal
dilute/coacervate
phase
ratio
for
given
reactant
partitioning.
Furthermore,
accelerate
polymerization
self‐replication
lead
formation
longer
polymers.
Lastly,
‘rescue’
oscillating
networks
concentration
regimes
sustained
oscillations
do
not
occur
single‐phase
system.
Our
results
indicate
direct
wide
range
impact
fundamental
aspects
such
yield,
pathway
selection,
product
length
emergent
functions.
This
may
have
far‐reaching
implications
life,
synthetic
cells
fate
function
biological
condensates.
