Factors Affecting Composition and Diversity of Gut Microbiota: A Disease Hallmark DOI
Rohan Samir Kumar Sachan,

Khushboo,

Inderpal Devgon

et al.

Published: Sept. 7, 2023

Gut microbiota is regarded as a rich reservoir of symbiotic and opportunistic microorganisms. These are essential to maintain healthy lifestyle they play role in digestion, excretion, other physiological metabolic activities the body. The host releases certain bioactive compounds such antimicrobial peptides, non-specific factors immunoglobins, micro RNAs that help foster beneficial microorganisms restrict growth pathogens. Its imbalance, dysbiosis, compromises human health, causing inflammation immune system related abnormalities. Diet, age, chemical consumption, excess use antibiotics main lead fluctuation gut microbiota. Dysbiosis leads wide range disturbances including diarrhea, cramping, constipation, indigestion. In this chapter, we highlight fluctuations normal mediated by internal external agents. Further, elucidation on probiotics balancing microbial diversity composition will be delineated.

Language: Английский

The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis DOI Creative Commons
Farzaneh Fakharian,

Siva Thirugnanam,

David A. Welsh

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1849 - 1849

Published: July 21, 2023

The gut microbiome plays a critical role in maintaining overall health and immune function. However, dysbiosis, an imbalance composition, can have profound effects on various aspects of human health, including susceptibility to viral infections. Despite numerous studies investigating the influence infections microbiome, impact dysbiosis infection pathogenesis remains relatively understudied. clinical variability observed SARS-CoV-2 seasonal influenza infections, presence natural HIV suppressors, suggests that host-intrinsic factors, may contribute pathogenesis. has been shown host system by regulating intestinal homeostasis through interactions with cells. This review aims enhance our understanding how perturb mucosal cells, affecting response Specifically, we focus exploring between gamma delta (γδ) T cells microbes context inflammatory examine highlighting disease outcomes. Furthermore, discuss emerging evidence potential future directions for modulation therapy

Language: Английский

Citations

43
HIV-1–Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities DOI Open Access
Sonia Moretti,

Ivan Schietroma,

Giuseppe Sberna

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12193 - 12193

Published: July 30, 2023

HIV-1 replication in the gastrointestinal (GI) tract causes severe CD4+ T-cell depletion and disruption of protective epithelial barrier intestinal mucosa, causing microbial translocation, main driver inflammation immune activation, even people living with HIV (PLWH) taking antiretroviral drug therapy. The higher levels DNA gut compared to blood highlight importance as a viral reservoir. subsets differ phenotypic characteristics differentiation status from ones other tissues or peripheral blood, little is still known about mechanisms by which persistence maintained at this anatomical site. This review aims describe interaction key T cells mucosa targeted role microbiome its metabolites HIV-associated systemic activation that are crucial pathogenesis infection related comorbidities.

Language: Английский

Citations

12
Dyslipidemia is a Major Side Effect of Long-Term Antiretroviral Therapy DOI Creative Commons
Nemanja Djordjevic, Sofija Marković, Nataša Minić

et al.

Experimental and Applied Biomedical Research (EABR), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Abstract The aim of this study was to investigate the impact different antiretroviral therapy on lipid status HIV patients with emphasis modern-generation drugs. A cross-sectional conducted at Clinic for Infectious Diseases University Clinical Center Kragujevac and included forty-six infection a minimum twelve months. Lipid parameters were analyzed in relation length administration type used (integrase inhibitors or other groups). average duration intake ± standard deviation 5.59 3.649. Statistically significant higher values low-density lipoprotein cholesterol recorded after six years that does not belong group integrase compared period less than three (p<0.05). After all groups therapy, total increase significantly (p<0,01 p<0,05, respectively). Patients groups, show statistically (p<0,05). Although tendency over time both therapy) they do differ, which means have greater growth. Despite use dyslipidemia is present percentage patients.

Language: Английский

Citations

0
Taxonomic and functional profile of the anorectal microbiota in HIV‐positive and HIV‐negative men who have sex with men, using a metagenomic approach DOI Open Access

Paula Natalia Hernández‐Trujillo,

Camila Andrea Lopez‐Barón,

Gabriela Arévalo‐Pinzón

et al.

HIV Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Introduction The study of bacterial diversity in human samples is crucial for developing biomarkers health and disease. This research characterized the taxonomic functional anorectal microbiota men who hae sex with (MSM) HIV compared to from this group without HIV. Materials Methods In July August 2023, self‐collected swabs were obtained. DNA was extracted each sample, metagenomic sequencing performed. With obtained data, alpha beta diversity, abundance, differential operational units, determined. Results Initially, 90 collected, 20 discarded due having less than 200 ng 15 incomplete sequencing, leaving 55 analysed (15 HIV‐positive 40 HIV‐negative). No significant differences found between groups terms (Shannon index p = 0.45) (PERMANOVA R −0.03). Prevotella identified as most abundant genus both groups. Twelve genes be more group, which promote growth, colonization survival. Conclusion Alterations could influence pathogenesis its complications population, underscoring need investigate these mechanisms explore interventions improve health. Longitudinal studies are needed analyse changes during infection response treatment, integrating metagenomic, clinical, immunological data better understand interactions HIV, host

Language: Английский

Citations

0
Nutraceutical metabolites, value addition and industrial products for developing entrepreneurship through edible fleshy fungi DOI

R.L. Pandey,

Vaibhav Sharan Pandey,

V. N. Pandey

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 293 - 328

Published: Jan. 1, 2024

Language: Английский

Citations

1
Factors Affecting Composition and Diversity of Gut Microbiota: A Disease Hallmark DOI
Rohan Samir Kumar Sachan,

Khushboo,

Inderpal Devgon

et al.

Published: Sept. 7, 2023

Gut microbiota is regarded as a rich reservoir of symbiotic and opportunistic microorganisms. These are essential to maintain healthy lifestyle they play role in digestion, excretion, other physiological metabolic activities the body. The host releases certain bioactive compounds such antimicrobial peptides, non-specific factors immunoglobins, micro RNAs that help foster beneficial microorganisms restrict growth pathogens. Its imbalance, dysbiosis, compromises human health, causing inflammation immune system related abnormalities. Diet, age, chemical consumption, excess use antibiotics main lead fluctuation gut microbiota. Dysbiosis leads wide range disturbances including diarrhea, cramping, constipation, indigestion. In this chapter, we highlight fluctuations normal mediated by internal external agents. Further, elucidation on probiotics balancing microbial diversity composition will be delineated.

Language: Английский

Citations

1