Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

---

Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

---

The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 194 - 194

Published: Jan. 18, 2024

Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically patients suffering from certain ailments. Although this knowledge was empirical past tomes, modern science has already verified it and expanded new limits. These microorganisms can be found nature various foods such as dairy products supplements formulated for clinical preventive use. The current review examines the different mechanisms of action probiotic strains how they interact with organism host. Emphasis is put on therapeutic use these beneficial conditions gastrointestinal tract. Diseases tract particularly any malfunction inflammation intestines seriously compromise whole organism. interaction between host’s microbiota alleviate signs symptoms while some cases, due course, intervene underlying pathology. Various safety issues probiotics also discussed.

Language: Английский

---

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 28, 2024

The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It over 2.47 million deaths through various syndromes such as distress, hypercoagulability, and multiple organ failure. viral invasion proceeds the ACE2 receptor, expressed in cell types, some patients serious damage to tissues, organs, immune cells, microbes that colonize gastrointestinal tract (GIT). Some who survived SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae COVID-19 (PASC). Diagnosis these revealed biological effects, none which are mutually exclusive. However, severity also depends on numerous comorbidities obesity, age, diabetes, hypertension care must be taken with respect other morbidities, host immunity. Gut microbiota relation immunopathology is considered evolve progression via mechanisms biochemical metabolism, exacerbation inflammation, intestinal mucosal secretion, cytokine storm, immunity regulation. Therefore, modulation gut microbiome equilibrium food supplements probiotics remains a hot topic current research debate. In this review, we discuss complications physio-pathological effects infection, GIT response, therapeutic pharmacological strategies. We summarize targets probiotics, their limitations, efficacy preclinical clinical drugs effectively inhibit spread SARS-CoV-2.

Language: Английский

---

Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 220 - 220

Published: Sept. 18, 2024

Chronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the response cortisol, glucocorticoid hormone produced by adrenal glands. While cortisol release adaptive in acute stress, prolonged exposure elevated levels can result adverse effects. This manuscript explores neurobiological of chronic its impact on metabolic dysregulation, particularly context inflammatory bowel diseases (IBDs). The hypothalamic-pituitary-adrenal (HPA) axis regulates production, which influences metabolism, immune response, neurobiology. Elevated are associated development exacerbation disorders like IBD contribute neurodegenerative processes, including cognitive impairments increased susceptibility psychiatric conditions. interaction between receptors, underscores complexity these review aims elucidate mechanisms through dysregulation health function, providing insights into potential therapeutic strategies mitigating

Language: Английский

---

Effects of Physical Exercise on the Microbiota in Irritable Bowel Syndrome

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2657 - 2657

Published: Aug. 11, 2024

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain, bloating, diarrhea, and constipation. Recent studies have underscored the significant role of gut microbiota in pathogenesis IBS. Physical exercise, as non-pharmacological intervention, has been proposed to alleviate IBS symptoms modulating microbiota. Aerobic such running, swimming, cycling, shown enhance diversity abundance beneficial bacteria, including Lactobacillus Bifidobacterium. These bacteria produce short-chain fatty acids that possess anti-inflammatory properties support barrier integrity. Studies involving patients participating structured aerobic exercise programs reported improvements their microbiota's composition diversity, alongside an alleviation like pain bloating. Additionally, positively influences mental health reducing stress improving mood, which can further relieve via gut-brain axis. Long-term interventions provide sustained benefits, maintaining stability, supporting immune functions, systemic inflammation. However, must be tailored individual needs avoid exacerbating symptoms. Personalized plans starting with low-to-moderate intensity gradually increasing maximize benefits minimize risks. This review examines impact various types intensities physical on patients, highlighting need for explore optimal protocols. Future research should include larger sample sizes, longer follow-up periods, examine synergistic effects other lifestyle modifications. Integrating into comprehensive management symptom control improve patients' quality life.

Language: Английский

---

Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

---

Diverse Colonisation and Disease Associations of the Human Commensal Malassezia: Our Body's Secret Tenant

Mycoses, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 1, 2025

ABSTRACT A niche in the context of microorganisms defines specific ecological role or habitat inhabited by microbial species within an ecosystem. For human commensal Malassezia , skin surface is considered its primary niche, where it adapts to environment utilising lipids as main carbon and energy source. However pathogenic characteristics include production allergens, immune modulation excessive lipid utilisation, which result several diseases such pityriasis versicolor, seborrheic dermatitis, folliculitis atopic dermatitis. Recent studies have revealed colonisation internal organs, including lungs, gut, genitourinary tract, eyes, ears breast milk. In these associated with linked respiratory conditions, neurological disorders, gastrointestinal genital infections. The system plays a critical shaping prevalence, factors like, suppressive drugs underlying health conditions influencing susceptibility. Accurate diagnosis ‐related disorders challenging due unique growth requirements, but molecular fingerprinting assays sequencing methods, particularly ITS sequencing, offer precise identification. Treatment involves antifungal drugs, corticosteroids phytocompounds, yet recurrent infections highlight need for more targeted therapeutic strategies addressing 's characteristics. Understanding complex interactions between host organs crucial diagnosis, treatment prevention exploring potentially beneficial roles disease. This review highlights current findings on intricate diverse ecosystem body, underscoring complexity associations emphasising their multifaceted

Language: Английский

---

Population-specific differences in the human microbiome: Factors defining the diversity

Gene, Journal Year: 2024, Volume and Issue: 933, P. 148923 - 148923

Published: Sept. 6, 2024

Language: Английский

---

Therapeutic Potential of Cajanus cajan (L.) Millsp. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 67 - 67

Published: Jan. 9, 2025

Background/Objectives: Inflammatory bowel disease (IBD) is a persistent inflammatory condition affecting the gastrointestinal tract, distinguished by impairment of intestinal epithelial barrier, dysregulation gut microbiota, and abnormal immune responses. Cajanus cajan (L.) Millsp., traditionally used in Chinese herbal medicine for issues such as bleeding dysentery, has garnered attention its potential therapeutic benefits. However, effects on IBD remain largely unexplored. Methods: In this study, major compounds from leaf extract (CCLE) were initially characterized LCMS-IT-TOF. The model was developed C57BL/6 mice administering continuous 4% (w/v) dextran sodium sulfate (DSS) aqueous solution over period seven days. body weight, colon length, activity index (DAI), histopathological examination using hematoxylin eosin (H&E) staining performed model. levels main factors, specifically TNF-α, IL-1β, IL-6, myeloperoxidase (MPO), quantified employing enzyme-linked immunosorbent assay (ELISA) kits. Additionally, tight junction proteins (ZO-1, Occludin) oxidative stress enzymes (iNOS, SOD1, CAT) investigated qPCR. Subsequently, flow cytometry employed to analyze populations various cells within spleen, thereby assessing impact CCLE systemic homeostasis mice. Finally, 16S rDNA sequencing conducted examine composition relative abundance microbiota across different experimental groups. addition, molecular docking analysis assess interaction between principal components aryl hydrocarbon receptor (AHR). Results: We identified bioactive CCLE: catechin, cajachalcone, 2-hydroxy-4-methoxy-6-(2-phenylcinyl)-benzoic acid, longistylin A, C, pinostrobin, amorfrutin cajaninstilbene acid. Our results demonstrated that oral administration significantly alleviates symptoms DSS-induced modulating balance gut-derived pro- anti-inflammatory cytokines. This modulation associated with functional correction M1/M2 macrophage polarization Th17/Treg cell splenic cells, well shifts harmful bacteria (Erysipelatoclostridium Staphylococcus) beneficial (Odoribacter, unidentified Oscillospiraceae, Lachnoclostridium, Oscillibacter) gut. Furthermore, C AhR agonists. Conclusions: present suggested CCLE, comprising stilbenes like protects barrier's structure function against acute restoring response Overall, represents promising natural product-based strategy treating

Language: Английский

---