ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(43), P. 58072 - 58099
Published: Oct. 21, 2024
Atherosclerosis-induced
coronary
artery
disease
is
a
major
cause
of
cardiovascular
mortality.
Clinically,
conservative
treatment
strategies
for
atherosclerosis
still
focus
on
lifestyle
interventions
and
the
use
lipid-lowering
anticoagulant
medications.
Despite
achieving
some
therapeutic
effects,
these
approaches
are
limited
by
low
bioavailability,
long
intervention
periods,
significant
side
effects.
With
advancement
nanotechnology,
nanomaterials
have
demonstrated
extraordinary
potential
in
biomedical
field.
Their
excellent
biocompatibility,
surface
modifiability,
high
targeting
capability
not
only
enable
efficient
diagnosis
plaque
progression
but
also
allow
precise
drug
delivery
within
atherosclerotic
plaques,
significantly
enhancing
bioavailability
reducing
systemic
Here,
we
systematically
review
current
research
progress
field
to
summarize
types
their
applications
both
atherosclerosis.
Notably,
context
therapy,
provide
comprehensive
overview
nanomaterial
based
targeted
systems
different
cell
plaques.
Additionally,
address
persistent
challenge
clinical
translation
summarizing
issues
providing
directions
innovation
improvement
design.
Overall,
believe
that
this
summarizes
challenges
thereby
offering
insights
references
development
materials
Critical Reviews in Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 29
Published: March 27, 2025
The
urgent
need
for
sensitive,
rapid,
and
reliable
diagnostic
methodologies
to
control
prevent
life-threatening
pandemic
infectious
disease,
such
as
COVID-19,
remains
a
critical
priority.
Timely
on-site
detection
of
viral
pathogens
is
essential
effective
disease
management
mitigation
societal
disruptions.
Recent
advancements
in
optical
methods
have
positioned
them
at
the
forefront
healthcare
diagnostics,
offering
high
sensitivity
specificity
viable
alternatives
conventional
techniques
Polymerase
Chain
Reaction
(PCR),
which
often
suffer
from
time
delays
limited
accessibility
resource-constrained
environments.
This
review
elucidates
potential
various
techniques,
highlighting
their
advantages
over
traditional
methods.
It
encompasses
range
modalities,
including
fluorescence-based
approaches,
Raman
spectroscopy
(RS),
Plasmonic
(e.g.,
surface
plasmon
resonance
(SPR),
localized
SPR,
(LSPR),
surface-enhanced
(SERS),
fluorescence
(SEF)),
super
resolution
microscopies
(SRMs),
attenuated
total
reflectance-Fourier
transform
infrared
(ATR-FTIR),
integrated
platforms
waveguides
molecularly
imprinted
polymer
(MIP)-based
biosensors.
Additionally,
evolution
novel
biosensors,
particularly
5th
6th
generation
challenges
related
these
technologies
were
discussed.
studies
reviewed
aims
advance
development
portable,
specific,
cost-effective
point-of-care
(POC)
devices
rapid
pathogens.
This
paper
underlines
the
critical
need
for
novel
diagnostic
techniques
against
increasing
worldwide
burden
of
neurodegenerative
disorders
(NDDs).
The
intricacies
Alzheimer's,
Parkinson's,
and
Huntington's
necessitate
very
accurate
sensitive
early
detection
strategies.
In
addition,
it
provides
an
essential
look
at
promise
role
nanotechnology
potential
nanoscale
material
technology
integration
to
revolutionize
preclinical
disease
diagnostics.
Furthermore,
allows
pinpoint
identification
biomarkers
pathological
alterations.
We
discussed
different
types
nanotools,
including
nanoparticles,
nanosensors,
imaging
agents,
nanomedicine.
process
metamorphosis,
however,
has
its
challenges.
development
these
cutting-edge
instruments
necessitates
careful
thought
on
issues
ethics,
safety,
biocompatibility.
Despite
limitations,
nanotools'
importance
in
changing
course
screening
is
undeniable.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(43), P. 58072 - 58099
Published: Oct. 21, 2024
Atherosclerosis-induced
coronary
artery
disease
is
a
major
cause
of
cardiovascular
mortality.
Clinically,
conservative
treatment
strategies
for
atherosclerosis
still
focus
on
lifestyle
interventions
and
the
use
lipid-lowering
anticoagulant
medications.
Despite
achieving
some
therapeutic
effects,
these
approaches
are
limited
by
low
bioavailability,
long
intervention
periods,
significant
side
effects.
With
advancement
nanotechnology,
nanomaterials
have
demonstrated
extraordinary
potential
in
biomedical
field.
Their
excellent
biocompatibility,
surface
modifiability,
high
targeting
capability
not
only
enable
efficient
diagnosis
plaque
progression
but
also
allow
precise
drug
delivery
within
atherosclerotic
plaques,
significantly
enhancing
bioavailability
reducing
systemic
Here,
we
systematically
review
current
research
progress
field
to
summarize
types
their
applications
both
atherosclerosis.
Notably,
context
therapy,
provide
comprehensive
overview
nanomaterial
based
targeted
systems
different
cell
plaques.
Additionally,
address
persistent
challenge
clinical
translation
summarizing
issues
providing
directions
innovation
improvement
design.
Overall,
believe
that
this
summarizes
challenges
thereby
offering
insights
references
development
materials
