Multifunctional hydrogel bioscaffolds based on polysaccharide to promote wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129356 - 129356

Published: Jan. 11, 2024

Language: Английский

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Biomedical Applications of Electrets: Recent Advance and Future Perspectives

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(6), P. 320 - 320

Published: June 12, 2023

Recently, electrical stimulation, as a non-pharmacological physical stimulus, has been widely exploited in biomedical and clinical applications due to its ability significantly enhance cell proliferation differentiation. As kind of dielectric material with permanent polarization characteristics, electrets have demonstrated tremendous potential this field owing their merits low cost, stable performance, excellent biocompatibility. This review provides comprehensive summary the recent advances applications. We first provide brief introduction development electrets, well typical materials fabrication methods. Subsequently, we systematically describe applications, including bone regeneration, wound healing, nerve drug delivery, wearable electronics. Finally, present challenges opportunities also discussed emerging field. is anticipated state-of-the-art insights on stimulation-related electrets.

Language: Английский

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Injectable carboxymethyl chitosan-based hydrogel for simultaneous anti-tumor recurrence and anti-bacterial applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 230, P. 123196 - 123196

Published: Jan. 10, 2023

Language: Английский

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Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 98 - 98

Published: Jan. 23, 2023

Postoperative adhesion is a common post-surgery complication formed between the surface of body cavity, ranging from layer connective tissue to fibrous bridge containing blood vessels and nerve tissue. Despite achieving lot progress, mechanisms formation still need be further studied. In addition, few current treatments are consistently effective in prevention postoperative adhesion. Hydrogel kind water-expanding crosslinked hydrophilic polymer network generated by simple reaction one or more monomers. Due porous structure, hydrogels can load different drugs control drug release kinetics. Evidence existing studies has confirmed feasibility superiority using counter adhesions, primarily due their outstanding antifouling ability. this review, research status as anti-adhesion barriers summarized, character briefly introduced, future directions discussed.

Language: Английский

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Structure-activity relationships of bioactive polysaccharides extracted from macroalgae towards biomedical application: A review

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121533 - 121533

Published: Oct. 26, 2023

Language: Английский

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In situ forming alginate/gelatin hybrid hydrogels containing doxorubicin loaded chitosan/AuNPs nanogels for the local therapy of breast cancer

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 246, P. 125640 - 125640

Published: July 1, 2023

Language: Английский

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Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 18, 2023

Due to oral nano-delivery systems for the treatment of inflammatory bowel disease (IBD) are often failed accumulated colonic site and could not achieve controlled drug release, it's urgent develop a microenvironment responsive delivery improve therapy efficacy. Inflammation at IBD is mainly mediated by macrophages, which key effector cells. Excessive inflammation leads oxidative stress intestinal mucosal damage. The use curcumin (CUR) emodin (EMO) together promising due their respective anti-inflammatory repair effects. In view pH gradient environment gastrointestinal tract, here we prepared pH-responsive sodium alginate (SA) hydrogel-coated nanoemulsions co-deliver CUR EMO (CUR/EMO NE@SA) release specifically target macrophages colon.In this study, CUR/EMO NE@SA was successfully developed, in NE loaded chitosan further crosslinked with alginate. had property colon. preparation significantly alleviate colon decreasing TNF-α IL-6 expression, increasing IL-10 scavenging reactive oxygen species ameliorating restoration tight junction protein expression. Furthermore, revealed molecular mechanism treatment, might synergic inhibition NF-κB pro-inflammatory microenvironment. Our study provides new strategy via synergically inhibiting inflammatory, repairing clearing ROS pH-sensitive hydrogel-encapsulated nanoemulsion system, be developed other chronic treatment.It's suggested that nanoemulsion-based codelivery combinatorial platform IBD.

Language: Английский

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Preparation of Biocompatible Manganese Selenium-Based Nanoparticles with Antioxidant and Catalytic Functions

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4498 - 4498

Published: June 1, 2023

The specificity of the tumor microenvironment (TME) severely limits effectiveness treatment. In this study, we prepared a composite nanoparticle manganese dioxide and selenite by one-step redox method, their stability under physiological conditions was improved with bovine serum protein modification to obtain MnO

Language: Английский

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Intelligent hydrogel on–off controller sensor for irrigation

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 7(1)

Published: Dec. 31, 2023

Language: Английский

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AgNPs-loaded chitosan/sodium alginate hydrogel film by in-situ green reduction with tannins for enhancing antibacterial activity

Materials Today Communications, Journal Year: 2023, Volume and Issue: 38, P. 107927 - 107927

Published: Dec. 22, 2023

Language: Английский

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