International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136392 - 136392
Published: Oct. 1, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12917 - 12932
Published: May 9, 2024
Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of broad bioactivity high compatibility polyphenols, there is considerable interest developing a polyphenol-based collaborative platform remodel IBD regulate microbiota. Here, we demonstrated coordination assembly nanostructured polyphenols modify probiotics simultaneously deliver drugs for treatment. Inspired by distinctive structure tannic acid (TA), fabricated pBDT-TA using self-polymerizable aromatic dithiol (BDT) TA, which exhibited excellent antioxidant anti-inflammatory capability vitro. We thus coated sodium alginate (SA) surface Escherichia coli Nissle 1917 layer construct EcN@SA-pBDT-TA. The modified showed improved resistance oxidative inflammatory stress, resulted superior colon accumulation retention model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate (DSS)-induced colitis controlling response, repairing barriers, modulating gut Importantly, EcN@SA-pBDT-TA-mediated drug delivery achieve an therapeutic effect DSS Given availability functionality polyphenol prebiotics, expected that polyphenol-modified provided solution develop
Language: Английский
Citations
25
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151756 - 151756
Published: April 30, 2024
Language: Английский
Citations
17
Gels, Journal Year: 2024, Volume and Issue: 10(5), P. 295 - 295
Published: April 25, 2024
Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization drug encapsulation, transport, controlled release, complemented by biocompatibility, biodegradability, non-immunogenic nature. Stimuli-responsive hydrogels, also known smart have strictly regulated release patterns since they respond adapt based various external stimuli. Moreover, can imitate the intrinsic tissues’ mechanical, biological, physicochemical properties. These characteristics allow stimuli-responsive hydrogels provide cutting-edge, effective, safe treatment. Constant progress field necessitates an up-to-date summary of current trends breakthroughs biomedical application chitosan-based was aim this review. General data about sensitive ions, pH, redox potential, light, electric field, temperature, magnetic are recapitulated. Additionally, responsive multiple stimuli mentioned. Focusing multifaceted thoroughly described. The vast spectrum encompasses neurological disorders, tumors, wound healing, dermal infections. Available chitosan strongly support idea that approaches developing novel solutions worth improving. present paper constitutes valuable resource researchers practitioners currently field.
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 575 - 575
Published: Jan. 11, 2025
Inflammatory bowel disease (IBD), encompassing Crohn's and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Current immune-modulating therapies are insufficient for 30-50% patients or cause significant side effects, emphasizing need new treatments. Targeting innate immune system enhancing drug delivery to inflamed gut regions promising strategies. Neutrophils play a central role in IBD by releasing reactive oxygen species (ROS) neutrophil extracellular traps (NETs) -DNA-based structures with cytotoxic proteins-that contribute mucosal damage inflammation. Recent studies linking ROS production, DNA repair, NET formation have identified NETs as potential therapeutic targets, preclinical models showing positive outcomes from inhibition. Innovative oral systems designed target directly-without systemic absorption-could improve treatment precision reduce effects. Advanced formulations utilize properties such particle size, surface modifications, ROS-triggered release selectively distal ileum colon. A dual strategy that combines deeper understanding pathophysiology identify inflammation-related targets advanced may offer promise. For instance, pairing inhibition ROS-responsive nanocarriers could enhance efficacy, though further research is needed. This synergistic approach has greatly patients.
Language: Английский
Citations
1
Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1659 - 1659
Published: April 7, 2024
Curcumin (CCM) is a polyphenol compound extracted from the turmeric rhizome. It has various biological activities, including antibacterial, anti-inflammatory, anti-cancer, and antioxidant. Due to its diverse it often used by researchers study therapeutic effects on diseases. However, poor solubility leads bioavailability, necessary increase water with help of carriers improve effect. Gastrointestinal disease major global health problem that continues affect human health. In this review, we have summarized possible mechanism effect CCM in gastrointestinal diseases, improvement curative nanopreparation. Finally, concluded there been many clinical trials combination other drugs for treatment disease, but so far, few nanomaterials treatment. Although vitro preclinical experiments shown nanopreparations can efficacy CCM, are still insufficient studies safety carriers.
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135775 - 135775
Published: Sept. 1, 2024
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133956 - 133956
Published: July 17, 2024
Language: Английский
Citations
5
Journal of Tissue Engineering, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 1, 2024
The incidence of ulcerative colitis (UC) is rapidly rising worldwide. Oral drug delivery system a promising approach for treating UC, but it often fails to accumulate the inflammatory lesions, thus, impressive develop colon-targeted oral preventing systemic toxicity and maintaining UC therapeutics. Here, negative-charged PLGA nanoparticle was designed encapsulate celastrol (Cel), then chitosan mannose were coated on surface nanoparticles (MC@Cel-NPs) endow these with mucosal adsorption macrophage targeting abilities. MC@Cel-NPs demonstrate excellent resist decomposition ability against strong acidic gastrointestinal environment, accumulates in specific sites through affinity electrostatic reaction. After releasing payload, could remarkably alleviate colon inflammation, which evidenced by decrease pro-inflammatory cytokines TNF-α, IL-1β, IL-6 both blood sections, scavenging reactive oxygen species (ROS) cells, including macrophage, neutrophil, T cell, B cell. This provided new Chinese herbal ingredient-related manner.
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1333 - 1333
Published: Oct. 17, 2024
Nanoemulsions (NEs) are submicron-sized heterogeneous biphasic liquid systems stabilized by surfactants. They physically transparent or translucent, optically isotropic, and kinetically stable, with droplet sizes ranging from 20 to 500 nm. Their unique properties, such as high surface area, small size, enhanced bioavailability, excellent physical stability, rapid digestibility, make them ideal for encapsulating various active substances. This review focuses on recent advancements, future prospects, challenges in the field of NEs, particularly oral, parenteral, ophthalmic delivery. It also discusses clinical trials patents. Different types vitro vivo NE characterization techniques summarized. High-energy low-energy preparation methods briefly described diagrams. Formulation considerations commonly used excipients ocular, drug delivery presented. The emphasizes need new functional improve permeation large molecular weight unstable proteins, oligonucleotides, hydrophilic drugs advance rapidly.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 8, 2025
The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention the recent years. As field rapidly evolves, analyzing research trends and identifying hotpots are essential for guiding future advancements, a comprehensive bibliometric can provide valuable insights. current focused on publications from 2001 to 2024, was sourced Web Science Core Collection (WoSCC). CiteSpace VOSviewer were employed visualize authors, institutions, countries, co-cited references, keywords, thereby mapping intellectual structure emerging field. analysis covered 1,518 literature across 447 journals, authored by 9,334 researchers 5,459 institutions 287 countries/regions. global publication numbers exhibited an upward trend, particularly last decade, with China leading as top publishing country Chinese Academy Sciences foremost institution. Dr. Xiao Bo is prominent figure advanced drug delivery systems. This interdisciplinary field, which spans materials science, pharmacy, medicine, seen influential mainly concentrated targeted nanoparticles treatment IBD. Keyword revealed that hotspots include delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, nanovesicles. study offers overview landscape, emphasizing rapid growth increasing complexity this It identifies key trends, including efforts enhance precision, efficacy, safety applications. Emerging directions highlighted crucial further progress evolving area.
Language: Английский
Citations
0