Advanced Science,
Journal Year:
2024,
Volume and Issue:
12(2)
Published: Nov. 18, 2024
Abstract
Phosphate
and
phosphonate
drugs
are
vital
in
building
organisms,
regulating
physiological
processes,
exhibiting
diverse
biological
activities,
including
antiviral,
antibacterial,
antineoplastic,
enzyme‐inhibitory
effects.
However,
their
therapeutic
potential
is
limited
by
the
lack
of
advanced
nanoengineering
technologies.
Herein,
a
competitive
coordination
strategy
for
phosphate/phosphonate
introduced.
By
leveraging
difference
capabilities
between
polyphenols
phosphates/phosphonates
with
metal
ions,
various
phosphate/phosphonate‐based
nanodrugs
using
metal‐phenolic
networks
(MPNs)
as
templates
agents
constructed.
The
dynamic
nature
these
bonds
imparts
stimuli‐responsiveness
to
nanodrugs,
allowing
targeted
release
therapy.
As
proof
concept,
Fe
3+
galangin
used
form
MPN
template,
zoledronic
acid
cGAMP
agents,
DOX
loaded
drug
construct
DOX@Fe‐galangin@Fe‐zoledronic
acid‐cGAMP
nanodrugs.
results
demonstrate
that,
triggering
pyroptosis
activating
cGAS‐STING
pathway,
exhibit
potent
cytotoxicity
accurate
selectivity
eradicating
orthotopic
breast
tumors,
activate
an
antitumor
immune
response
against
lung
bone
metastases.
Because
applicable
variety
it
holds
significant
enhancing
clinical
efficacy
advancing
nanodrug
development
complex
applications.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
99, P. 105919 - 105919
Published: July 2, 2024
Clobetasol-17-proprionate
(CP)
is
the
most
potent,
highly
lipophilic
topical
corticosteroid,
used
for
treatment
of
immune-mediated
muco-cutaneous
diseases.
No
commercial
preparations
are
available
oral
cavity
and
galenic
formulations
often
ineffective
due
to
easy
displacement
by
saliva
muscular
movements.
Here,
we
developed
characterized
novel
mucoadhesive
patches
CP
delivery
on
mucosa.
Bilayer
chitosan
(CS)-based
(CS-CP)
were
produced
via
electrophoretic
deposition
(EPD)
physical
biological
properties.
CS-CP
showed
a
porous
structure
at
surface
towards
mucosa
(containing
CP)
more
compact
occlusive
backing
layer
(without
CP).
displayed
fast
swelling
(301.6
±
0.8
%)
in
PBS,
while
sustained
release
was
observed
over
time,
both
vitro
PBS
using
an
ex
vivo
model
porcine
mucosa,
with
about
40
%
released
after
6
h.
did
not
affect
properties
patches.
Through
3D
patches'
cytocompatibility
activity
regulating
immune
response-related
pathways
evaluated.
CS-based
represent
innovative
biocompatible
biomedical
devices
able
successfully
loading
drugs,
including
CP.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
12(2)
Published: Nov. 18, 2024
Abstract
Phosphate
and
phosphonate
drugs
are
vital
in
building
organisms,
regulating
physiological
processes,
exhibiting
diverse
biological
activities,
including
antiviral,
antibacterial,
antineoplastic,
enzyme‐inhibitory
effects.
However,
their
therapeutic
potential
is
limited
by
the
lack
of
advanced
nanoengineering
technologies.
Herein,
a
competitive
coordination
strategy
for
phosphate/phosphonate
introduced.
By
leveraging
difference
capabilities
between
polyphenols
phosphates/phosphonates
with
metal
ions,
various
phosphate/phosphonate‐based
nanodrugs
using
metal‐phenolic
networks
(MPNs)
as
templates
agents
constructed.
The
dynamic
nature
these
bonds
imparts
stimuli‐responsiveness
to
nanodrugs,
allowing
targeted
release
therapy.
As
proof
concept,
Fe
3+
galangin
used
form
MPN
template,
zoledronic
acid
cGAMP
agents,
DOX
loaded
drug
construct
DOX@Fe‐galangin@Fe‐zoledronic
acid‐cGAMP
nanodrugs.
results
demonstrate
that,
triggering
pyroptosis
activating
cGAS‐STING
pathway,
exhibit
potent
cytotoxicity
accurate
selectivity
eradicating
orthotopic
breast
tumors,
activate
an
antitumor
immune
response
against
lung
bone
metastases.
Because
applicable
variety
it
holds
significant
enhancing
clinical
efficacy
advancing
nanodrug
development
complex
applications.
