Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 13, 2023
Abstract
Photothermal
therapy
(PTT)
and
photodynamic
(PDT)
are
effective
method
for
tumor
treatment.
However,
the
limited
variety
quantity
of
photothermal
agents
(PTAs)
photosensitizer
(PSs)
still
major
challenges.
Moreover,
cell
apoptosis
mechanism
induced
by
PDT
PTT
is
elusive.
A
fused-ring
small
molecule
acceptor-donor
acceptor′
donor-acceptor
(A-DA′D-A)
type
Y5
(
Scheme
1
)
has
a
narrow
band-gap
strong
light
absorption.
Herein,
we
used
to
polymerize
with
thiophene
unit
obtain
polymer
PYT
based
on
polymerized
strategy,
nanoparticles
(PYT
NPs)
was
prepared
via
one-step
nanoprecipitation
strategy
DSPE-PEG
2000
.
NPs
had
excellent
biocompatibility,
good
photostability,
high
conversion
efficiency
(67%)
reactive
oxygen
species
(ROS)
production
capacity
under
808
nm
laser
irradiation
+
NIR).
In
intro
in
vivo
experiments
revealed
that
NIR
ability
completely
ablate
cells.
It
demonstrated
closely
related
mitochondrial
damage.
This
study
provides
valuable
guidance
constructing
high-performance
organic
PTAs
PSs
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 17, 2023
Triple
positive
breast
cancer
(TPBC)
is
one
of
the
most
aggressive
cancer.
Due
to
unique
cell
phenotype,
aggressiveness,
metastatic
potential
and
lack
receptors
or
targets,
chemotherapy
choice
treatment
for
TNBC.
Doxorubicin
(DOX),
representative
agents
anthracycline
chemotherapy,
has
better
efficacy
in
patients
with
TNBC
(mTNBC).
DOX
anthracycline-based
regimens
have
higher
response
rates.
Nano-drug
delivery
systems
possess
targeting
ability
co-load,
deliver
release
chemotherapeutic
drugs,
active
gene
fragments
immune
enhancing
factors
effectively
inhibit
kill
tumor
cells.
Therefore,
advances
nano-drug
therapy
attracted
a
considerable
amount
attention
from
researchers.
In
this
article,
we
reviewed
progress
(e.g.,
Nanoparticles,
Liposomes,
Micelles,
Nanogels,
Dendrimers,
Exosomes,
etc.)
applied
We
also
summarize
current
clinical
trials
combined
checkpoint
inhibitors
(ICIS)
The
merits,
demerits
future
development
nanomedicine
are
envisioned,
aim
providing
new
class
safe
efficient
thoughts
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 115997 - 115997
Published: Dec. 20, 2023
Nullomers
are
the
shortest
strings
of
absent
amino
acid
(aa)
sequences
in
a
species
or
group
species.
Primes
those
nullomers
that
have
not
been
detected
genome
any
9S1R
is
5-aa
peptide
prime
sequence
attached
to
5-arginine
aa,
used
treat
triple
negative
breast
cancer
(TNBC)
an
vivo
mouse
model.
This
unique
peptide,
administered
with
trehalose
carrier
(9S1R-NulloPT),
offers
enhanced
solubility
and
exhibits
distinct
anti-cancer
effects
against
TNBC.
In
our
study,
we
investigated
effect
9S1R-NulloPT
on
tumor
growth,
metabolism,
metastatic
burden,
immune-microenvironment
(TME),
transcriptome
aggressive
TNBC
tumors.
Notably,
treated
mice
had
smaller
tumors
initial
phase
treatment,
as
compared
untreated
control,
diminished
ex
bioluminescence
at
later-stages
-
indicative
metabolically
quiescent,
dying
The
treatment
also
caused
changes
TME
increased
infiltration
immune
cells
altered
transcriptome,
365
upregulated
genes
710
downregulated
genes.
Consistent
vitro
data,
were
enriched
cellular
metabolic
processes
(179),
specifically
mitochondrial
TCA
cycle/oxidative
phosphorylation
(44),
translation
machinery/ribosome
biogenesis
(45).
associated
developmental
(13),
ECM
organization
(12)
focal
adhesion
pathways
(7).
conclusion,
study
demonstrates
effectively
reduced
growth
during
its
phase,
altering
transcriptome.
induced
pathology
which
led
deceleration
tumors,
aligning
observations.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116446 - 116446
Published: March 20, 2024
Herein,
we
constructed
innovative
reduction-sensitive
and
targeted
gelatin-based
micelles
for
doxorubicin
(DOX)
delivery
in
tumor
therapy.
AS1411
aptamer-modified
gelatin-ss-tocopherol
succinate
(AGSST)
the
control
GSST
without
modification
were
synthesized
characterized.
Antitumor
drug
DOX-containing
AGSST
(AGSST-D)
GSST-D
nanoparticles
prepared,
their
shapes
almost
spherical.
Reduction-responsive
characteristics
of
DOX
release
vitro
revealed
AGSST-D
GSST-D.
Compared
with
non-targeted
GSST-D,
demonstrated
better
intracellular
uptake
stronger
cytotoxicity
against
nucleolin-overexpressed
A549
cells.
Importantly,
showed
more
effective
killing
activity
A549-bearing
mice
than
DOX⋅HCl.
It
was
that
had
no
obvious
systemic
toxicity.
Overall,
would
have
potential
to
be
an
carrier
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Dec. 20, 2023
Abstract
Photothermal
therapy
(PTT)
and
photodynamic
(PDT)
are
effective
method
for
tumor
treatment.
However,
the
limited
variety
quantity
of
photothermal
agents
(PTAs)
photosensitizer
(PSs)
still
major
challenges.
Moreover,
cell
apoptosis
mechanism
induced
by
PDT
PTT
is
elusive.
A
fused-ring
small
molecule
acceptor–donor
acceptor′
donor–acceptor
(A-DA′D-A)
type
Y5
(Scheme
1)
has
a
narrow
band-gap
strong
light
absorption.
Herein,
we
used
to
polymerize
with
thiophene
unit
obtain
polymer
PYT
based
on
polymerized
strategy,
nanoparticles
(PYT
NPs)
was
prepared
via
one-step
nanoprecipitation
strategy
DSPE-PEG
2000
.
NPs
had
excellent
biocompatibility,
good
photostability,
high
conversion
efficiency
(67%)
reactive
oxygen
species
(ROS)
production
capacity
under
808
nm
laser
irradiation
+
NIR).
In
vitro
in
vivo
experiments
revealed
that
NIR
ability
completely
ablate
cells.
It
demonstrated
closely
related
mitochondrial
damage.
This
study
provides
valuable
guidance
constructing
high-performance
organic
PTAs
PSs
