Tumor-targeted delivery of SNHG15 siRNA using a ZIF-8 nanoplatform: Towards a more effective prostate cancer therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129233 - 129233

Published: Jan. 4, 2024

Language: Английский

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Advancing Cancer Therapy with Quantum Dots and Other Nanostructures: A Review of Drug Delivery Innovations, Applications, and Challenges

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 878 - 878

Published: March 4, 2025

Nanotechnology, particularly quantum dots (QDs), has ushered in a transformative era the pharmaceutical and medical industries, offering notable opportunities for nanoscale advancements. These particles, known their exceptional optical properties confinement, have emerged as indispensable tools cancer drug delivery bioimaging. This review delves into various conjugation techniques with QDs, including covalent linking, non-covalent conjugation, click chemistry, disulfide linkage, pH-sensitive linkage. Each method provides distinct advantages, such enhanced stability, reversibility, specificity, controlled release. Moreover, QDs demonstrated significant promise oncology by efficiently delivering drugs to cancerous tissues while minimising systemic toxicity. Investigations applications different cancers, blood, brain, cervical, breast etc., reveal efficacy targeted delivery, real-time imaging, improved therapeutic outcomes. However, challenges potential toxicity, pharmacokinetics, targeting specificity must be addressed fully harness benefits of therapy. Future research should focus on developing biocompatible optimising techniques, elucidating safety profiles long-term effects biological systems. Overall, represent promising frontier treatment, multifaceted capabilities that hold outcomes reduced side across cancers.

Language: Английский

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Enhanced theranostic efficacy of epirubicin-loaded SPION@MSN through co-delivery of an anti-miR-21-expressing plasmid and ZIF-8 hybridization to target colon adenocarcinoma

Nanoscale, Journal Year: 2024, Volume and Issue: 16(12), P. 6215 - 6240

Published: Jan. 1, 2024

The SPION@MSN-EPI/pDNA-ZIF-8-PEG-Apt nanocarrier showcases exceptional plasmid stability, drug loading, and controlled release. Its outstanding anti-tumor efficacy through targeted chemo–gene therapy is supported by its imaging traceability.

Language: Английский

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Advancements in Colorectal Cancer Treatment: The Role of Metal-Based and Inorganic Nanoparticles in Modern Therapeutic Approaches

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 264, P. 155706 - 155706

Published: Nov. 6, 2024

Language: Английский

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Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 8, 2025

Colorectal cancer (CRC) is one of thes most prevalent malignant tumors worldwide. Current therapeutic strategies for CRC have limitations, while nanomaterials show significant potential diagnosing and treating CRC. This study utilizes bibliometric analysis to evaluate the current status trends in this field. Research on from 2003 2024 was retrieved Web Science Core Collection (WOSCC). Tools such as CiteSpace, VOSviewer, RStudio, GraphPad Prism, Excel were used analyze hotspots, covering publication trends, countries, institutions, authors, journals, co-citation analysis, keywords. Visual maps created forecast future developments. The includes 3,683 publications by 17,261 authors 3,721 institutions across 100 countries/regions, published 840 journals. Global steadily increased, particularly since 2018. China leads volume citations, with six top ten research seven cited United States excels citation impact academic centrality. Both countries currently dominate field, underscoring urgent need enhanced international collaboration. Ramezani M Abnous K lead H-index, Siegel RL highly cited. International Journal Nanomedicine has highest volume, Controlled Release In addition "colorectal cancer" "nanoparticles," common keyword "drug delivery." Emerging areas "metal-organic frameworks (MOFs)" "green synthesis" are gaining attention leading hotspots. offers an in-depth application CRC, promoting interdisciplinary collaboration advancing scientific progress

Language: Английский

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UiO-based platforms in biomedicine: Advanced nanovehicles for effective treatment

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102645 - 102645

Published: March 22, 2025

Language: Английский

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The utilization of metal-organic frameworks in tumor-targeted drug delivery systems

Journal of Science Advanced Materials and Devices, Journal Year: 2024, Volume and Issue: 9(3), P. 100770 - 100770

Published: July 23, 2024

Due to the non-specific distribution of drugs in body and low concentration at tumor site traditional chemotherapy, there are challenges associated with significant side effects resistance. Therefore, a drug delivery system (DDS) urgently needs be developed that can precisely target tumors. Metal-organic frameworks (MOFs) possess advantageous characteristics derived from organic inorganic materials, including small particle size, large specific surface area, high loading capacity, adjustable structure pore as well ease modification. Consequently, MOFs offer unique advantages for designing active targeting, passive stimulus-responsive targeting strategies have become hot topic current research on tumor-targeted systems. This review will elaborate application systems perspective different strategies. We hope this paper provide assistance therapy.

Language: Английский

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Application of dual chemotherapeutic drug delivery system based on metal-organic framework platform in enhancing tumor regression for breast cancer research

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 710, P. 149889 - 149889

Published: April 4, 2024

Language: Английский

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Current landscape of metal–organic framework-mediated nucleic acid delivery and therapeutics

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125295 - 125295

Published: Feb. 1, 2025

Language: Английский

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Metal-organic framework nanoparticles activate cGAS-STING pathway to improve radiotherapy sensitivity

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 21, 2025

Tumor immunotherapy aims to harness the immune system identify and eliminate cancer cells. However, its full potential is hindered by immunosuppressive nature of tumors. Radiotherapy remains a key treatment modality for local tumor control immunomodulation within microenvironment. Yet, efficacy radiotherapy often limited radiosensitivity, traditional radiosensitizers have shown effectiveness in hepatocellular carcinoma (HCC). To address these challenges, we developed novel multifunctional nanoparticle system, ZIF-8@MnCO@DOX (ZMD), designed enhance drug delivery tissues. In microenvironment, Zn²⁺ Mn²⁺ ions released from ZMD participate Fenton-like reaction, generating reactive oxygen species (ROS) that promote cell death improve radiosensitivity. Additionally, release doxorubicin (DOX)-an anthracycline chemotherapeutic agent-induces DNA damage apoptosis The combined action metal double-stranded (dsDNA) damaged cells synergistically activates cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway, thereby initiating robust anti-tumor response. Both vitro vivo experiments demonstrated effectively cGAS-STING promotes responses, exerts potent tumor-killing effect combination with radiotherapy, leading regression both primary tumors distant metastases. Our work provides straightforward, safe, effective strategy combining treat advanced cancer.

Language: Английский

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