Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(24), P. 2022 - 2022
Published: Dec. 16, 2024
Sclerotinia
sclerotiorum
is
one
of
the
fungi
that
cause
plant
diseases.
It
damages
plants
by
secreting
large
amounts
oxalic
acid
and
cell
wall-degrading
enzymes.
To
meet
this
challenge,
we
designed
a
new
pH/enzyme
dual-responsive
nanopesticide
Pro@ZnO@Pectin
(PZP).
This
uses
zinc
oxide
(ZnO)
as
carrier
prochloraz
(Pro)
encapsulated
with
pectin.
When
encountering
released
sclerotiorum,
acidic
environment
promotes
decomposition
ZnO;
at
same
time,
pectinase
produced
can
also
decompose
outer
pectin
layer
PZP,
thereby
promoting
effective
release
active
ingredient.
Experimental
data
showed
PZP
was
able
to
achieve
an
efficient
rate
57.25%
68.46%
when
added
or
under
conditions,
respectively.
In
addition,
in
vitro
tests
antifungal
effect
comparable
commercial
Pro
(Pro
SC)
on
market,
its
efficacy
1.40
times
1.32
original
drug
TC),
Crucially,
application
significantly
alleviated
detrimental
impacts
wheat
development.
Soil
wetting
experiments
have
proved
primarily
remained
soil,
decreasing
likelihood
contaminating
water
sources
reducing
potential
risks
non-target
organisms.
Moreover,
improved
foliar
wettability
Pro,
lowering
contact
angle
75.06°.
Residue
analyses
indicated
did
not
elevate
residue
levels
tomato
fruits
compared
conventional
applications,
indicating
formulation
does
lead
excessive
pesticide
buildup.
summary,
shows
great
promise
for
effectively
managing
while
minimizing
environmental
impact.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 3, 2025
The
fluorescent
vesicles
based
on
lanthanide
ions
are
considered
as
an
ideal
biomimetic
optical
nanoplatform
for
simulating
biological
processes
of
cell
membrane.
However,
the
accurately
and
controllably
adjusting
size
lanthanides
while
ensuring
their
fluorescence
performance
stability
still
remains
a
challenge.
Herein,
dual-stimuli-responsive
supramolecular
vesicle
with
tunable
has
been
designed
host-guest
interaction
coordinating
aggregation.
Europium
complexes
can
be
encapsulated
within
assemblies
by
assembling
polypseudorotaxanes
(PPRs),
which
formed
F127
carboxymethyl-β-cyclodextrin
(CMCD)
through
interaction.
properties
europium
have
significantly
enhanced
confining
shielding
them
vesicles.
Upon
addition
α-amylase
HCl,
intensity
will
gradually
quench
result
CMCD
degradation
dissociation
complexes.
This
research
presents
convenient
method
regulating
vesicles,
obtained
multi-stimuli
response
anticipated
to
utilized
in
diagnosis
relevant
diseases
targeted
drug
delivery.
Pesticide
delivery
carriers
provide
protection
against
pathogens
but
face
significant
challenges,
including
limited
loading
capacity,
rapid
release
rates,
and
inconsistent
performance.
To
address
these
issues,
this
study
develops
a
dual-stimuli-responsive
pesticide
carrier,
featuring
an
iron-copper
bimetal-organic
framework
(Fe-Cu
MOF)
supported
on
diatomaceous
earth
(DE)
coated
with
lauric
acid
(LA).
Here,
DE
serves
as
biocompatible
scaffold,
enhancing
the
adhesion
retention
of
MOF
particles
at
target
sites,
thereby
improving
localization
efficiency.
The
carrier
exhibits
high
thiabendazole
(Tbz)
capacity
38.14%
owing
to
its
nanoporous
structure.
LA
coating
functions
pH-
temperature-responsive
barrier,
regulating
prolong
treatment
duration
minimizing
need
for
repeated
applications.
demonstrates
controlled
rates
80.73%
pH
5
96.55%
40
°C,
confirming
dual-stimuli
responsiveness.
In
vitro
assays
reveal
92.26%
inhibition
Botrytis
cinerea
1
μg
mL-1,
while
in
vivo
experiments
tomato
plants
fruits
show
complete
200
mL-1.
Additionally,
developed
composites
adhere
strongly
leaves
through
electrostatic
hydrogen-bonding
interactions,
reducing
loss
due
rain
erosion.
Overall,
DE-MOF-Tbz-LA
presents
promising
efficient
alternative
conventional
Journal of Materials Science Materials in Medicine,
Journal Year:
2024,
Volume and Issue:
35(1)
Published: June 19, 2024
Abstract
This
study
leverages
nanotechnology
by
encapsulating
indocyanine
green
(ICG)
and
paclitaxel
(Tax)
using
zeolitic
imidazolate
frameworks-8
(ZIF-8)
as
a
scaffold.
aims
to
investigate
the
chemo-photothermal
therapeutic
potential
of
ZIF-8@ICG@Tax
nanoparticles
(NPs)
in
treatment
non-small
cell
lung
cancer
(NSCLC).
An
“all-in-one”
theranostic
NPs
was
conducted
self-assembly
based
on
electrostatic
interaction.
First,
photothermal
effect,
stability,
pH
responsiveness,
drug
release,
blood
compatibility
were
evaluated
through
vitro
testing.
Furthermore,
hepatic
renal
toxicity
assessed
vivo
Additionally,
anticancer
effects
these
investigated
both
vivo.
Uniform
stable
had
been
successfully
synthesized
outstanding
releasing
capacities.
Moreover,
showed
remarkable
responsiveness
dependent
tumor
microenvironment
NIR
irradiation,
allowing
for
targeted
delivery
controlled
release.
irradiation
can
enhance
response
uptake,
thereby
promoting
anti-tumor
growth
have
demonstrated
synergistic
properties
compared
their
individual
components.
novel
hold
great
viable
option
NSCLC.
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