Microfluidic Manufacture of Composite Fibers for Biomedical Applications DOI
Rodrigo Dores, Mónica Oliveira, Luís M. Bimbo

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Abstract Fibrous materials are essential structural elements widely distributed throughout natural systems. In order to replicate and harness the unique properties of fibers, microfluidic technologies have been employed refined allow for a precise control over mechanical properties, diameter, alignment, morphology spun fibers. To further their versatility adaptability, better mimic counterparts, microfluidics also allowed integration multiple functional components at microscale giving rise composite These composed combination different materials, offer wide range functionalities that surpass those individual can be tailored specific applications. This review discusses various fabrication methods, highlighting advantages limitations. The compares synthetic polymers in fiber manufacture examines influence process parameters on such as strength, porosity, biocompatibility incorporation nanoparticles, biomolecules, microstructures within fibers tailor functionality biomedical Finally, paper provides an outline current trends well future directions field.

Language: Английский

3D Printing‐Based Hydrogel Dressings for Wound Healing DOI Creative Commons
Xuan Zhou,

Xunzhou Yu,

Tingting You

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(47)

Published: Nov. 18, 2024

Abstract Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of best candidates for ideal wound dressings most feasible choices printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic mechanical properties, 3D can promptly accurately create with complex bioactive structures potential promote tissue regeneration healing. Herein, a comprehensive review multi‐functional printing‐based hydrogel healing is presented. The first summarizes techniques dressings, including photo‐curing, extrusion, inkjet, laser‐assisted printing. Then, properties design approaches series bioinks composed natural, synthetic, composite polymers described. Thereafter, application in variety environments discussed depth, hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, machine learning‐assisted therapy. Finally, challenges prospects

Language: Английский

Citations

14
Oxidized hyaluronic acid/ε-polylysine/quaternized chitosan hydrogel with shear thinning injectability and self-healing properties for full-time and multipurpose wound healing DOI

Huiyuan Zheng,

Xiaofeng Zhang, Weijiang Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 293, P. 139347 - 139347

Published: Jan. 2, 2025

Language: Английский

Citations

0
ATPSpin: A Single Microfluidic Platform that Produces Diversified ATPS-Alginate Microfibers DOI
Niloofar Ghasemzaie, Morteza Jeyhani,

Kushal Joshi

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3896 - 3908

Published: May 15, 2024

Microfluidic spinning is emerging as a useful technique in the fabrication of alginate fibers, enabling applications drug screening, disease modeling, and diagnostics. In this paper, by capitalizing on benefits aqueous two-phase systems (ATPS) to produce diverse fiber forms, we introduce an ATPS-Spinning platform (ATPSpin). This ATPS-enabled method efficiently circumvents rapid clogging challenges inherent traditional production techniques regulating interaction between cross-linking agents like Ba2+ ions. By varying system parameters under guidance regime map, our produces several forms─solid, hollow, droplet-filled─consistently reproducibly from single device. We demonstrate that resulting fibers possess distinct features, including biocompatibility. also encapsulate HEK293 cells microfibers proof-of-concept versatile microfluidic generation may have utility tissue engineering regenerative medicine applications.

Language: Английский

Citations

2
Microfluidic-based cardiovascular systems for advanced study of atherosclerosis DOI

Huiyuan Zheng,

Lei Tai,

Chengbin Xu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(30), P. 7225 - 7245

Published: Jan. 1, 2024

Atherosclerosis (AS) is a significant global health concern due to its high morbidity and mortality rates. Extensive efforts have been made replicate the cardiovascular system explore pathogenesis, diagnosis, treatment of AS. Microfluidics has emerged as valuable technology for modeling studying Here brief review advances microfluidic-based systems AS research presented. The critical pathogenetic mechanisms investigated by are categorized reviewed, with detailed summary accurate diagnostic methods detecting biomarkers using microfluidics represented. Furthermore, covers evaluation screening drugs assisted microfluidic systems, along fabrication novel drug delivery carriers. Finally, challenges future prospects advancing in discussed proposed, particularly regarding new opportunities multi-disciplinary fundamental therapeutic applications broader range disease treatments.

Language: Английский

Citations

1
Aqueous Two-Phase Systems - versatile and advanced (bio)process engineering tools DOI
Alexandre M.S. Jorge, Jorge F. B. Pereira

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Aqueous two-phase systems are the “Swiss Army Knives” for creating cost-effective and sustainable solutions in advanced (bio)process engineering.

Language: Английский

Citations

1
A review on multifunctional calcium alginate fibers for full-time and multipurposed wound treatment: From fundamentals to advanced applications DOI

Feng-Lan Xu,

Yang Gao,

Huan Xin

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139133 - 139133

Published: Dec. 1, 2024

Language: Английский

Citations

1
Microfluidic Manufacture of Composite Fibres for Biomedical Applications DOI
Rodrigo Dores, Mónica Oliveira, Luís M. Bimbo

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Microfluidic Manufacture of Composite Fibers for Biomedical Applications DOI
Rodrigo Dores, Mónica Oliveira, Luís M. Bimbo

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Abstract Fibrous materials are essential structural elements widely distributed throughout natural systems. In order to replicate and harness the unique properties of fibers, microfluidic technologies have been employed refined allow for a precise control over mechanical properties, diameter, alignment, morphology spun fibers. To further their versatility adaptability, better mimic counterparts, microfluidics also allowed integration multiple functional components at microscale giving rise composite These composed combination different materials, offer wide range functionalities that surpass those individual can be tailored specific applications. This review discusses various fabrication methods, highlighting advantages limitations. The compares synthetic polymers in fiber manufacture examines influence process parameters on such as strength, porosity, biocompatibility incorporation nanoparticles, biomolecules, microstructures within fibers tailor functionality biomedical Finally, paper provides an outline current trends well future directions field.

Language: Английский

Citations

0