Synergistic antibacterial and antifouling wound dressings: Integration of photothermal-activated no release and zwitterionic surface modification

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 657, P. 124160 - 124160

Published: April 24, 2024

Language: Английский

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Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Candida auris has emerged as a significant global health threat due to its multidrug resistance and ability form robust biofilms, particularly on medical devices hospital surfaces. Biofilms protect C. from antifungal treatments the host immune response, making infections persistent difficult control. This review explores potential of nanoparticles overcome limitations traditional therapies in combating biofilms. Nanoparticles, with their unique physicochemical properties, offer promising strategies penetrate biofilm matrices, deliver agents, disrupt structure. Various types nanoparticles, including metallic, polymeric, lipid-based, cyclodextrin-based, demonstrate enhanced penetration activity. Their generate reactive oxygen species, cell adhesion, release antifungals controlled manner makes them ideal candidates for biofilm-targeted therapies. presents current advancements nanoparticle-based solutions, emphasizing need further research into mechanisms action, safety, clinical application. By addressing challenge biofilms specifically, this provides critical synthesis existing knowledge identifies future directions developing effective using nanotechnology. Graphical abstract

Language: Английский

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Trends in pH-Triggered Strategies for Dental Resins Aiming to Assist in Preventing demineralization: a scoping review

Journal of Dentistry, Journal Year: 2024, Volume and Issue: 153, P. 105540 - 105540

Published: Dec. 20, 2024

Language: Английский

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Recent Trends and Outcomes in Oral Cancer Targeting Using Nano-Sized Drug Delivery Systems

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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H₂O₂ Self‐Supplying CaO₂/POM@MOF Bimodal Nanogeneration Materials for Photothermal and Chemodynamic Synergistic Antimicrobials

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 30, 2024

ABSTRACT The emergence of bacterial resistance has a negative impact on the conventional antimicrobial treatments, and research into development new materials is great significance. Multimodal synergistic exert better effects compared with single modality. In recent years, Polyoxometalate (POM) shown potential in biomedical field due to its high catalytic activity photothermal conversion ability. However, owing small surface area, applications have been greatly limited. Herein, we designed H 2 O self‐supplied CDT PTT bimodal nanogeneration material (i.e., CaO /POM@MOF) possessing larger area for treatment infections, which could release weakly acidic microenvironment infection dual site POM@MOF enhance reaction generate ROS, resulting oxidative stress leakage contents, exposure NIR light generates localized temperature that cause rupture cell membranes denaturation their proteins. Meanwhile, superior stability can fewer metal ions improve biocompatibility. vitro experiments demonstrated /POM@MOF possessed combined effect exhibited excellent efficacy. This work presents promising strategy combat infections.

Language: Английский

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Green-Synthesized Nanoparticles: An Alternative to Conventional Nanoparticles to Treat microbial Biofilm

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 6, 2024

Language: Английский

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