Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 20
Published: Oct. 16, 2024
Nanoscale
drug
delivery
systems
that
are
both
multifunctional
and
targeted
have
been
developed
using
proteins
as
a
basis,
thanks
to
their
attractive
biomacromolecule
properties.
A
novel
nanocarrier,
aptamer
(AS1411)-conjugated
β-lactoglobulin/poly-l-lysine
(BLG/Ap/PL)
nanoparticles,
was
in
this
study.
To
unique
formulation,
the
as-prepared
nanocarrier
blends
distinctive
features
of
an
chemotherapeutic
targeting
agent
with
those
protein
nanocarriers.
By
loading
cabazitaxel
(CTX)
onto
nanocarriers,
therapeutic
potential
BLG/Ap/PL
could
be
demonstrated.
The
CTX-loaded
(CTX@BLG/Ap/PL)
showed
regulated
release
profile
acidic
milieu,
which
improve
efficacy
cancer
cells
high
encapsulation
up
93%.
However,
compared
free
CTX,
CTX@BLG/Ap/PL
killed
colorectal
HCT116
higher
at
24
48
h.
Further
investigation
confirms
apoptosis
by
acridine
orange
ethidium
bromide
(AO/EB),
DAPI
staining
morphological
changes,
chromatin
condensation,
membrane
blebbing
treated
cell
through
flow
cytometry
displayed
percentages
apoptosis.
Cell
cycle
analysis
revealed
induced
sub-G1
G2/M
phase
(apoptosis)
Annexin
V/propidium
iodide
(PI)
confirmed
induces
cells.
Overall,
study
proved
had
several
advantages
over
drugs
promise
solution
clinical
problems
associated
antitumor
systems.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: Jan. 16, 2025
The
objective
of
the
study
was
to
tackle
recurrence
prostate
cancer
(PCa)
post-surgery
and
re-sensitize
docetaxel
(DTX)-resistant
PC-3
cells
chemo-therapy
using
NIC.
Prolonged
DTX
therapy
leads
emergence
chemo-resistance
by
overexpression
PI3K-AKT
pathway
in
PCa
along
with
tumor
post-surgery.
Suppression
this
could
be
essential
improving
anticancer
activity
re-sensitizing
resistant
cells.
Niclosamide
(NIC),
an
anthelmintic
drug
has
shown
tremendous
potential
re-sensitized
various
drugs.
To
mitigate
post-surgical
recurrence,
implant-based
system
facilitating
sustained
release
NIC
beneficial.
were
incorporated
within
a
nanofiber
(NF)
prevent
on-site
local
DTX-resistant
fabricated
DTX-NIC
NF
via
electrospinning
334
±
96.14
nm
diameter
demonstrated
profile
till
6
d.
Elevated
mitochondrial
damage,
reactive
oxygen
species
levels
apoptotic
index
revealed
improvement
cytotoxicity
post
incorporation
into
owing
their
profile.
Re-sensitization
PC-3/DTX
observed
introduction
which
due
suppression
p-Akt1,
overexpressed
From
superior
re-sensitization
cells,
we
conclude
that
beneficial
therapeutic
regimen
preventing
PCa.
Materials,
Journal Year:
2024,
Volume and Issue:
17(16), P. 3916 - 3916
Published: Aug. 7, 2024
This
manuscript
explores
the
multifaceted
applications
of
polydopamine
(PDA)
across
various
scientific
and
industrial
domains.
It
covers
chemical
aspects
PDA
its
potential
in
bone
tissue
engineering,
implant
enhancements,
cancer
treatment,
nanotechnology.
The
investigates
PDA’s
roles
cell
culture
technologies,
surface
modifications,
drug
delivery
systems,
sensing
techniques.
Additionally,
it
highlights
contributions
to
microfabrication,
nanoengineering,
environmental
applications.
Through
detailed
testing
assessment,
study
identifies
limitations
PDA-related
research,
such
as
synthesis
complexity,
incomplete
mechanistic
understanding,
biocompatibility
variability.
also
proposes
future
research
directions
aimed
at
improving
techniques,
expanding
biomedical
applications,
enhancing
technologies
optimize
efficacy
scalability.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1536 - 1536
Published: Dec. 1, 2024
Background:
The
effectiveness
of
paclitaxel
(PTX)
in
treating
non-small-cell
lung
carcinoma
(NSCLC)
is
restricted
by
its
poor
pharmacokinetic
profile
and
side
effects.
This
limitation
stems
from
the
lack
a
suitable
delivery
vector
to
efficiently
target
cancer
cells.
Therefore,
there
critical
need
develop
an
efficient
carrier
for
optimised
PTX
NSCLC
therapy.
Methods:
present
study
describes
fabrication
mesoporous
polydopamine
(mPDA)
nano-bowls
via
emulsion-induced
interfacial
anisotropic
assembly
method,
designed
entrapment
pH-responsive
release
behaviour.
Results:
depicted
typical
bowl-like
shape,
with
connecting
channels
central
hollow
cavity,
allowing
optimal
loading
PTX.
fabricated
nanocarrier
system,
mPDA-PTX-nb,
had
mean
hydrodynamic
bowl
diameter
200.4
±
5.2
nm
surface
charge
−39.2
1.3
mV.
efficiency
within
was
found
be
95.7%,
corresponding
85.1%
achieved
at
acidic
pH
5.9
(simulated
tumour
microenvironment)
48
h.
Drug
best
fitted
Peppas–Sahlin
model,
indicating
involvement
both
diffusion
relaxation
mechanisms.
Treatment
mPDA-PTX-nb
significantly
suppressed
A549
cell
proliferation
72
h,
resulting
viability
14.0%
9.3%,
respectively,
highest
concentration
(100
µg/mL).
Conclusions:
These
results
highlight
potential
as
effective
PTX,
promoting
enhanced
anti-proliferative
effects
