This
study
aimed
to
develop
trastuzumab
(HCT)-functionalized
albumin
(BSA)-coated,
pyrotinib
(Ptb)-loaded
hollow
mesoporous
selenium
(HSE)
nanoparticles
(HBHSEP)
for
the
targeted
delivery
of
HER2-positive
breast
cancer.
Characterization
pharmaceutical
properties
in
vitro
revealed
that
HBHSEP
was
well
dispersed,
and
particle
size
172
±
3.4
nm.
In
release
experiments
effectively
controlled
Ptb
tumor
microenvironment
(high
glutathione
concentration),
with
a
cumulative
rate
86.5
4.2%
over
48
h.
Cell
uptake
vivo
imaging
confirmed
have
good
tumor-targeting
ability.
The
results
cell
experiments,
such
as
MTT,
flow
cytometry,
immunofluorescence
staining,
antitumor
can
significantly
promote
apoptosis
SK-BR-3
cells
inhibit
their
proliferation.
These
findings
strongly
show
may
be
an
effective
treatment
Inorganics,
Journal Year:
2025,
Volume and Issue:
13(1), P. 12 - 12
Published: Jan. 4, 2025
Breast
cancer
is
a
common
clinical
malignant
tumor
that
seriously
threatens
women’s
physical
and
mental
health.
Chemotherapy,
as
the
first
choice
of
breast
treatment,
has
limited
its
application
in
clinic
due
to
problems
poor
stability,
short
half-life,
serious
toxic
side
effects.
With
emergence
nanotechnology,
inorganic
materials
prepare
mesoporous
silica
nanoparticles
(MSNs)
have
been
widely
used
anti-tumor
drug
carriers.
However,
their
slow
degradation
rate
limits
biomedical
field.
Therefore,
developing
low-toxicity
MSNs
with
good
biocompatibility,
biodegradability,
rapid
release
at
site
key
scientific
issue
be
addressed.
Here,
we
prepared
DOX-loaded
Ca-Mg-doped
by
electrostatic
adsorption
obtain
Ca-Mg@DOX@MSNs
suitable
particle
sizes
zeta
potential,
incorporation
calcium
magnesium
also
led
an
increase
under
acidic
conditions
accelerated
release,
which
reduced
toxicity
DOX
promoted
cellular
uptake
This
study
provides
new
idea
for
treatment
cancer.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2813 - 2846
Published: March 1, 2025
Abstract:
Metal-based
nanoparticles
(MNPs)
have
great
potential
for
applications
in
wound
healing
and
tissue
engineering,
due
to
their
unique
structures,
high
bioactivities,
excellent
designability
characteristics,
an
increasing
number
of
studies
been
devoted
modifying
these
species
generate
novel
composites
with
desirable
optical,
electrical,
magnetic
properties.
However,
few
systematic
detailed
reviews
performed
relating
the
modification
approaches
available
MNPs
resulting
composites.
In
this
review,
a
comprehensive
summary
is
regarding
optimized
formulations
application
dressings,
techniques
used
prepare
composite
dressings
are
discussed.
addition,
safety
profiles
nanocomposite
limitations
reported
systems
evaluated.
More
importantly,
solution
strategies
proposed
address
limitations.
Overall,
review
provides
new
ideas
design
facilitate
field
skin
repair,
also
looks
into
future
direction
biomedical
field.
Keywords:
metal-based
nanoparticles,
nanocomposite,
dressing,
multi-functional,
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 1, 2025
The
creation
and
development
of
classical
multifunctional
nanomaterials
are
crucial
for
the
advancement
nanotherapeutic
treatments
tumors.
Currently,
metal–organic
frameworks
(MOFs)
modified
with
polydopamine
(PDA)
at
forefront
nanomedicine
research,
particularly
in
tumor
diagnostics
therapy,
owing
to
their
exceptional
biocompatibility,
expansive
specific
surface
area,
multifaceted
functionalities,
superior
photothermal
properties,
which
led
significant
advancements
anti-tumor
research.
Consequently,
a
range
anti-cancer
strategies
has
been
devised
by
leveraging
capabilities
MOFs,
including
intelligent
drug
delivery
systems,
photodynamic
tailored
microenvironment.
In
order
gain
deeper
insight
into
role
MOFs@PDA
cancer
diagnosis
treatment,
it
is
essential
conduct
comprehensive
review
existing
research
outcomes
promptly
analyze
challenges
associated
biological
applications.
This
will
provide
valuable
perspectives
on
potential
clinical
settings.
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(14), P. 1253 - 1269
Published: May 8, 2024
Cancer
is
one
of
the
leading
causes
mortality
worldwide,
and
its
treatment
faces
several
challenges.
Phytoconstituents
derived
from
recently
discovered
medicinal
plants
through
nanotechnology
potentially
target
cancer
cells
via
PI3K/Akt/mTOR
pathways
exert
their
effects
selectively
generation
reactive
oxygen
species
β-catenin
inhibition,
DNA
damage,
increasing
caspase
3/9
p53
expression.
These
nanocarriers
act
specifically
against
different
cell
lines
such
as
HT-29,
MOLT-4
human
leukemia
MCF-7
SKOV-3,
Caov-3,
SW-626,
HepG2,
A-549,
HeLa,
MCF-7.
This
review
comprehensively
elaborates
on
cellular
molecular
mechanisms,
therapeutic
prospects
various
plant-mediated
nanoformulations
to
attain
a
revolutionary
shift
in
immunotherapy.
Materials Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Deformed
organosilica
nanoprobes
(CDPF)
exhibit
enhanced
accumulation
within
larger
tumors,
highlighting
the
pivotal
role
of
tumor
microenvironment
in
optimization
nanoparticle-based
therapeutic
strategies.
