Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1117 - 1133
Published: Dec. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10377 - 10377
Published: Sept. 26, 2024
Polymers of natural origin, such as representatives various polysaccharides (e.g., cellulose, dextran, hyaluronic acid, gellan gum, etc.), and their derivatives, have a long tradition in biomedical applications. Among them, the use chitosan safe, biocompatible, environmentally friendly heteropolysaccharide has been particularly intensively researched over last two decades. The potential using for medical purposes is reflected its unique cationic nature, viscosity-increasing gel-forming ability, non-toxicity living cells, antimicrobial activity, mucoadhesiveness, biodegradability, well possibility chemical modification. intuitive clay minerals treatment superficial wounds known traditional medicine thousands years. To improve efficacy overcome ubiquitous bacterial resistance, beneficial properties utilized preparation chitosan–clay mineral bionanocomposites. focus this review on composites containing with montmorillonite halloysite minerals. This highlights antibacterial bionanocomposites drug delivery topical skin infections wound healing. Finally, an overview preparation, characterization, possible future perspectives related to these advancing applications presented.
Language: Английский
Citations
8
Applied Clay Science, Journal Year: 2025, Volume and Issue: 266, P. 107688 - 107688
Published: Jan. 5, 2025
Language: Английский
Citations
0
Applied Clay Science, Journal Year: 2025, Volume and Issue: 266, P. 107706 - 107706
Published: Jan. 16, 2025
Language: Английский
Citations
0
Applied Clay Science, Journal Year: 2025, Volume and Issue: 270, P. 107779 - 107779
Published: March 10, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Silver nanoparticles (Ag NPs) have emerged as a promising solution to combat biofilm-related infections caused by multidrug-resistant bacteria. However, their practical application remains limited due tendency aggregate and exhibit high toxicity at elevated concentrations. Here, we developed Citrus limon peel water extract-mediated hydrothermal process facilitate the heterogeneous nucleation of Ag NPs on attapulgite (APT) nanorods prepared Ag/APT nanocomposites with ultrasmall (<2 nm) uniformly anchored APT nanorods. Ascorbic acid polyphenols in extract acted electron donors reduce Ag+ Ag0, while interfacial interaction induced confined growth nanocrystals, resulting NPs. As result, synergistic effect targeted biofilm-binding affinity siginificantly increased specific surface area conducive release ions, obtained exhibited enhanced eradication activities antimicrobial-resistant bacterial biofilms accelerated wound healing MRSA-infected models. Additionally, attributing low dosage Ag, exceptional biocompatibility both vitro vivo. This work provides simple green strategy for preparation highly active Ag-based antibacterial nanomaterials sheds new light development advanced antimicrobial agents healing.
Language: Английский
Citations
0
ACS Omega, Journal Year: 2024, Volume and Issue: 9(16), P. 17760 - 17783
Published: April 8, 2024
Natural nano-minerals (NNMs) are minerals that derived from nature with a size of less than 100 nm in at least one dimension size. NNMs have number excellent properties due to their unique nanostructure and been applied various fields recent years. They rising stars disciplines, such as materials, biomedicine, chemistry, taking advantage huge surface area, multiple active sites, adsorption capacity, large quantity, low cost, nontoxicity, etc. To provide more comprehensive overview the biomedical applications NNMs-based nanocomposites, this review classifies into three types by dimension, lists structure typical NNMs, illustrates applications. Furthermore, novel concept natural nanomineral medical materials (NNMMs) is proposed, focusing on value NNMs. In addition, attempts address current challenges delineate future directions for advancement With deepening applications, it believed NNMMMs will inevitably play an important role field human health contribute its promotion.
Language: Английский
Citations
1
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 437 - 437
Published: June 30, 2024
Recent developments in biomimetic hydrogel research have expanded the scope of biomedical technologies that can be used to model, diagnose, and treat a wide range medical conditions. Cancer presents one most intractable challenges this arena due surreptitious mechanisms it employs evade detection treatment. In order address these challenges, design principles adapted beat cancer at its own game. Biomimetic strategies are inspired by natural biological systems offer promising opportunities for developing life-changing methods detect, treat, cure various types static metastatic cancers. particular, focusing on cellular subcellular phenomena serve as fundamental drivers peculiar behavioral traits provide rich insights into eradicating all manifestations. This review highlights nanocomposite hydrogels contribute therapies via enhanced drug delivery modeling mechanobiology relation metastasis synergistic sensing systems. Creative efforts amplify advance development more effective will discussed alignment with international collaborative goals cancer.
Language: Английский
Citations
1
Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 358(1)
Published: Dec. 26, 2024
Abstract Multidrug resistance (MDR) due to the overexpression of P‐glycoprotein (P‐gp) efflux pump remains a significant challenge in cancer therapy, also breast cancer. Traditional pharmacological approaches have focused on using inhibitors modulate P‐gp expression and function. Curcumin, polyphenol derived from Curcuma longa L., is one most extensively studied natural compounds with potential as an effective inhibitor. Despite its promising attributes, clinical application complicated by P‐gp's presence healthy cells, such those intestinal barrier blood–brain barrier, which can lead increased toxicity. To address these challenges, we developed novel multifunctional nanomaterial covalently bonding halloysite nanotubes (HNTs) hectorite (Ht) loading it curcumin doxorubicin. The efficacy co‐delivery doxorubicin HNTs‐Ht was evaluated cytotoxicity assays MCF‐7R both two‐dimensional (2D) three‐dimensional (3D) models. obtained data show that causes accumulation acting substrate for transport stimulator adenosine triphosphate (ATP)‐dependent drug transporter doxorubicin‐resistant cell line. results suggest could provide approach improve chemotherapy effectiveness overcoming MDR enhancing treatment outcomes.
Language: Английский
Citations
1
New Trends in Qualitative Research, Journal Year: 2024, Volume and Issue: 20(3), P. e1053 - e1053
Published: Aug. 26, 2024
Introducción: Este estudio examina la revolución tecnológica en el ámbito de los dispositivos médicos conectados, que están redefiniendo monitoreo, diagnóstico y tratamiento enfermedades. Se analiza cómo integración tecnologías avanzadas está impulsando atención médica personalizada a distancia. Objetivos: Evaluar avances conectados su impacto mejora del monitoreo investiga estas cambiando dinámica cuáles son desafíos oportunidades asociados. Metodología: utiliza un enfoque cualitativo, vinculando preguntas investigación con teorías resultados. El se basa análisis wearables sistemas implantables, combinando revisión literatura entrevistas expertos datos. metodológico permite una comprensión profunda interacción entre tecnología práctica médica. Resultados: Los hallazgos muestran ofrecen significativas ventajas términos precisión eficiencia, permitiendo seguimiento tiempo real mejor toma decisiones clínicas. identifican retos técnicos, éticos regulatorios, pero también destacan soluciones innovadoras para superarlos. Conclusiones: La subraya importancia cualitativo conectados. resultados enfatizan necesidad marco robusto evaluar tanto tecnológicos como contribuye transformando médica, enfatizando abordajes integrados multidisciplinarios maximizar sus beneficios minimizar riesgos.
Citations
0
Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1117 - 1133
Published: Dec. 1, 2024
Language: Английский
Citations
0