Diabetes and bacterial co-infection are two independent risk factors for respiratory syncytial virus disease severity

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 1, 2023

Diabetes mellitus (DM) is common among older adults hospitalized with lower respiratory tract infection, yet information on the impact of DM disease severity limited. This study retrospectively analyzed 46 Turkish patients infected syncytial virus (RSV), their comorbidities, co-infection status, and symptoms. Patients are grouped into four levels from mild to severe, according lung parenchymal infiltration status oxygen level. Similar previously published studies, we found that comorbidities diabetes, heart failure, hypertension, any type, bacterial co-infection, age associated severity. Cough most symptom (89%) followed by fever (26%) myalgia, dyspnea, weakness (around 20%). Using a second-order analysis (two-variable regression), identified two independent risks for severity, first represented second co-infection. We observed whose more severe symptoms were not an age, but combination diabetes To confirm true causality statistical correlation, further studies needed.

Language: Английский

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Approximate reciprocal relationship between two cause-specific hazard ratios in COVID-19 data with mutually exclusive events

The International Journal of Biostatistics, Journal Year: 2023, Volume and Issue: 20(1), P. 43 - 56

Published: March 30, 2023

Abstract COVID-19 survival data presents a special situation where not only the time-to-event period is short, but also two events or outcome types, death and release from hospital, are mutually exclusive, leading to cause-specific hazard ratios (csHR d csHR r ). The eventual mortality/release analyzed by logistic regression obtain odds-ratio (OR). We have following three empirical observations: (1) magnitude of OR an upper limit : |log(OR)| ≥ |log(csHR )|. This relationship between HR might be understood definition quantities; (2) point in opposite directions: log(csHR ) ⋅ < 0; relation direct consequence nature events; (3) there tendency for reciprocal ∼ 1/csHR . Though approximate trend indication that same factor causing faster lead slow recovery similar mechanism, vice versa, quantitative this context obvious. These results may help future analyses other diseases, particular if deceased patients lacking, whereas surviving abundant.

Language: Английский

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Comparação laboratorial entre pacientes falecidos por infecções virais na pandemia do SARS-CoV-2

Contribuciones a las Ciencias Sociales, Journal Year: 2024, Volume and Issue: 17(12), P. e13028 - e13028

Published: Nov. 26, 2024

Introdução: A crise sanitária e a subsequente econômica provocada pela pandemia do SARS-CoV-2 comprometeram os recursos das unidades de saúde globalmente. Os serviços menor porte precisam alternativas econômicas para o atendimento dos pacientes. Objetivo: Comparar resultados exames laboratoriais entre pacientes que faleceram por infecção outras infecções virais. Metodologia: Exames falecidos foram extraídos prontuários eletrônicos no Hospital PUC-Campinas, avaliados identificação preditores gravidade na comparação tiveram diagnóstico pelo Resultados: Proteína C Reativa lactato não apresentaram diferença estatisticamente significativa dois grupos. No hemograma, neutrófilos, linfócitos plaquetas diferentes. média monócitos foi mais elevada grupo COVID-19 (COVID) outros vírus (VIRAL), com p = 0,02. As relações as células como Índice Resposta Inflamatória Sistêmica, relaciona linfócitos, diferentes Entre eletrólitos estudados, cálcio ionizado semelhante. O magnésio potássio maiores COVID, 0,01 0,004, respectivamente. Já sódio SARS-CoV-2, 0,0006. Conclusão: Para manejo clínico internados novo coronavírus sugere-se coleta hemograma (monócitos) eletrólitos, monitorando-se especificamente sódio, magnésio.

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Blood-Type-A is a COVID-19 infection and hospitalization risk in a Turkish cohort

Transfusion Clinique et Biologique, Journal Year: 2022, Volume and Issue: 30(1), P. 116 - 122

Published: Oct. 13, 2022

Language: Английский

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