Cell Biology International,
Journal Year:
2022,
Volume and Issue:
46(7), P. 1009 - 1020
Published: March 24, 2022
Abstract
Almost
a
century
after
the
devastating
pandemic
of
Spanish
flu,
humankind
is
facing
relatively
comparable
global
outbreak
COVID‐19.
COVID‐19
an
infectious
disease
caused
by
SARS‐CoV‐2
with
unprecedented
transmission
pattern.
In
face
recent
repercussions
COVID‐19,
many
have
argued
that
clinical
experience
influenza
through
last
may
tremendous
implications
in
containment
this
newly
emerged
viral
disease.
During
2
years,
from
emergence
advances
been
made
diagnosing
and
treating
coinfections.
Several
approved
vaccines
are
available
now
for
primary
prevention
specific
treatments
exist
to
alleviate
symptoms.
The
present
review
article
aims
discuss
pathophysiology,
diagnosis,
treatment
A
virus
coinfection
while
delivering
bioinformatics‐based
insight
into
subject
matter.
Cell Biochemistry and Function,
Journal Year:
2022,
Volume and Issue:
40(8), P. 926 - 934
Published: Oct. 6, 2022
The
quick
widespread
of
the
coronavirus
and
speedy
upsurge
in
tally
cases
demand
fast
development
effective
drugs.
uridine-directed
endoribonuclease
activity
nonstructural
protein
15
(Nsp15)
is
responsible
for
invasion
host
immune
system.
Therefore,
developing
potential
inhibitors
against
Nsp15
a
promising
strategy.
In
this
concern,
silico
approach
can
play
significant
role,
as
it
cost-effective
comparison
to
trial
error
approaches
experimental
investigations.
study,
six
turmeric
derivatives
(curcuminoids)
were
chosen
analysis.
molecular
interactions,
pharmacokinetics,
drug-likeness
all
curcuminoids
measured.
Further,
stability
Nsp15-curcuminoids
complexes
was
appraised
by
employing
dynamics
(MD)
simulations
MM-PBSA
approaches.
All
molecules
affirmed
have
strong
interactions
pharmacokinetic
profile.
MD
data
stated
that
stable
during
simulations.
showed
high
binding
affinity,
these
could
be
admitted
modulators
inhibition.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
12
Published: March 25, 2022
COVID-19
is
threatening
human
health
worldwide
but
no
effective
treatment
currently
exists
for
this
disease.
Current
therapeutic
strategies
focus
on
the
inhibition
of
viral
replication
or
using
anti-inflammatory/immunomodulatory
compounds
to
improve
host
immunity,
not
both.
Traditional
Chinese
medicine
(TCM)
could
be
promising
candidates
due
their
safety
and
minimal
toxicity.
In
study,
we
have
developed
a
novel
in
silico
bioinformatics
workflow
that
integrates
multiple
databases
predict
use
honeysuckle
(
Lonicera
japonica
)
Huangqi
Astragalus
membranaceus
as
potential
anti-SARS-CoV-2
agents.
Using
extracts
from
Huangqi,
these
two
herbs
upregulated
group
microRNAs
including
let-7a
,
miR-148b
miR-146a
which
are
critical
reduce
pathogenesis
SARS-CoV-2.
Moreover,
suppressed
pro-inflammatory
cytokines
IL-6
TNF-α,
were
both
identified
cytokine
storm
acute
respiratory
distress
syndrome,
major
cause
death.
Furthermore,
partially
inhibited
fusion
SARS-CoV-2
spike
protein-transfected
BHK-21
cells
with
lung
cancer
cell
line
Calu-3
was
expressing
ACE2
receptors.
These
M
pro
activity,
thereby
alleviating
entry
well
replication.
conclusion,
our
findings
demonstrate
used
an
inhibitor
virus
warrants
further
vivo
analysis
functional
assessment
miRNAs
confirm
clinical
importance.
This
fast-screening
platform
can
also
applied
other
drug
discovery
studies
infectious
diseases.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(13), P. 11287 - 11368
Published: May 20, 2022
Despite
tremendous
efforts
in
the
past
two
years,
our
understanding
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
virus-host
interactions,
immune
response,
virulence,
transmission,
and
evolution
is
still
very
limited.
This
limitation
calls
for
further
in-depth
investigation.
Computational
studies
have
become
an
indispensable
component
combating
disease
2019
(COVID-19)
due
to
their
low
cost,
efficiency,
fact
that
they
are
free
from
safety
ethical
constraints.
Additionally,
mechanism
governs
global
transmission
SARS-CoV-2
cannot
be
revealed
individual
experiments
was
discovered
by
integrating
genotyping
massive
viral
sequences,
biophysical
modeling
protein-protein
deep
mutational
data,
learning,
advanced
mathematics.
There
exists
a
tsunami
literature
on
molecular
modeling,
simulations,
predictions
related
developments
drugs,
vaccines,
antibodies,
diagnostics.
To
provide
readers
with
quick
update
about
this
literature,
we
present
comprehensive
systematic
methodology-centered
review.
Aspects
such
as
biophysics,
bioinformatics,
cheminformatics,
machine
mathematics
discussed.
review
will
beneficial
researchers
who
looking
ways
contribute
those
interested
status
field.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
38(1), P. 7 - 10
Published: Feb. 14, 2023
Data
S1:
Supporting
Information.
Please
note:
The
publisher
is
not
responsible
for
the
content
or
functionality
of
any
supporting
information
supplied
by
authors.
Any
queries
(other
than
missing
content)
should
be
directed
to
corresponding
author
article.
Phytomedicine,
Journal Year:
2023,
Volume and Issue:
118, P. 154942 - 154942
Published: June 24, 2023
The
continuous
evolution
of
SARS-CoV-2
has
underscored
the
development
broad-spectrum
prophylaxis.
Antivirals
targeting
membrane
fusion
process
represent
promising
paradigms.
Kaempferol
(Kae),
an
ubiquitous
plant
flavonol,
been
shown
efficacy
against
various
enveloped
viruses.
However,
its
potential
in
anti-SARS-CoV-2
invasion
remains
obscure.To
evaluate
capabilities
and
mechanisms
Kae
preventing
invasion.To
avoid
interference
viral
replication,
virus-like
particles
(VLPs)
constructed
with
luciferase
reporter
were
applied.
To
investigate
antiviral
potency
Kae,
human
induced
pluripotent
stem
cells
(hiPSC)-derived
alveolar
epithelial
type
II
(AECII)
ACE2
(hACE2)
transgenic
mice
utilized
as
vitro
vivo
models,
respectively.
Using
dual
split
protein
(DSP)
assays,
inhibitory
activities
determined
Alpha,
Delta
Omicron
variants
SARS-CoV-2,
well
SARS-CoV
MERS-CoV.
further
reveal
molecular
determinants
restricting
fusion,
synthetic
peptides
corresponding
to
conserved
heptad
repeat
(HR)
1
2,
involved
mutant
form
HR2
explored
by
circular
dichroism
native
polyacrylamide
gel
electrophoresis.Kae
inhibited
both
vivo,
which
was
mainly
attributed
suppressive
effects
on
but
not
endocytosis,
two
pathways
that
mediate
invasion.
In
accordance
proposed
model
anti-fusion
prophylaxis,
functioned
a
pan-inhibitor
including
three
emerged
highly
pathogenic
coronaviruses,
currently
circulating
BQ.1.1
XBB.1
SARS-CoV-2.
Consistent
typical
target
inhibitors,
interacted
HR
regions
S2
subunits.
Distinct
from
previous
prevent
formation
six-helix
bundle
(6-HB)
competitively
interacting
HRs,
deformed
HR1
directly
reacted
lysine
residues
within
region,
latter
considered
critical
for
preservation
stabilized
during
invasion.Kae
prevents
infection
blocking
possesses
ability.
These
findings
provide
valuable
insights
into
benefits
Kae-containing
botanical
products
complementary
especially
waves
breakthrough
infections
re-infections.
