Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 4, 2024
Abstract
The
ongoing
global
pandemic
caused
by
the
SARS-CoV-2
virus
has
demanded
urgent
search
for
effective
therapeutic
interventions.
In
response,
our
research
aimed
at
identifying
natural
products
(NPs)
with
potential
inhibitory
effects
on
entry
of
spike
(S)
protein
into
host
cells.
Utilizing
Protein
Data
Bank
Japan
(PDBJ)
and
BindingDB
databases,
we
isolated
204
S-glycoprotein
sequences
conducted
a
clustering
analysis
to
identify
similarities
differences
among
them.
We
subsequently
identified
33,722
binding
molecules
(BMs)
matching
them
S-glycoproteins
compared
52,107
secondary
metabolites
(SMs)
from
KNApSAcK
database
inhibitors.
docking
drug-likeness
property
analyses
several
SMs
as
drug
candidates
based
energy
(BE),
no
Lipinski’s
rule
violation
(LV),
psychochemical
properties
within
pink
area
bioavailability
radar,
score
(BAS)
not
less
than
0.55.
Fourteen
were
found
be
against
three
major
types
proteins.
Our
study
provides
foundation
further
experimental
validation
these
compounds
agents
SARS-CoV-2.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 2, 2025
The
ongoing
global
pandemic
caused
by
the
SARS-CoV-2
virus
has
demanded
urgent
search
for
effective
therapeutic
interventions.
In
response,
our
research
aimed
at
identifying
natural
products
(NPs)
with
potential
inhibitory
effects
on
entry
of
spike
(S)
protein
into
host
cells.
Utilizing
Protein
Data
Bank
Japan
(PDBJ)
and
BindingDB
databases,
we
isolated
204
S-glycoprotein
sequences
conducted
a
clustering
analysis
to
identify
similarities
differences
among
them.
We
subsequently
identified
33,722
binding
molecules
(BMs)
matching
them
S-glycoproteins
compared
52,107
secondary
metabolites
(SMs)
from
KNApSAcK
database
inhibitors.
docking
drug-likeness
property
analyses
several
SMs
as
drug
candidates
based
energy
(BE),
no
Lipinski's
rule
violation
(LV),
psychochemical
properties
within
pink
area
bioavailability
radar,
score
(BAS)
not
less
than
0.55.
Fourteen
were
predicted
through
computational
inhibiting
three
major
types
S
proteins.
Our
study
provides
foundation
further
experimental
validation
these
compounds
agents
against
SARS-CoV-2.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 290 - 290
Published: Jan. 15, 2025
(1)
Background:
It
has
been
reported
that
people
affected
by
COVID-19,
an
infectious
disease
caused
SARS-CoV-2,
suffer
from
various
diseases,
after
infection.
One
of
the
most
serious
problems
is
increased
risk
developing
diabetes
COVID-19
However,
a
treatment
for
post-COVID-19
infection
not
yet
established.
In
this
study,
we
investigated
effects
Ficus
pumila
L.
extract,
which
traditionally
used
to
reduce
blood
glucose
levels
in
Okinawa,
on
patients
who
developed
(2)
Methods:
total,
128
rehabilitation
aged
80
years
old
or
older
were
included.
The
HOMA-β
(Homeostatic
model
assessment
β-cell
function)
and
HOMA-IR
insulin
resistance)
assessed
evaluate
tolerance.
(3)
Results:
decreased
Subsequently,
59
given
extract
their
improved
ingestion.
On
other
hand,
control
group
did
consume
showed
no
improvement
both
HOMA-IR.
(4)
Conclusions:
ingested
infection,
stimulated
secretion
capacity
resistance.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1024 - 1024
Published: Feb. 23, 2025
Tea
polyphenols,
the
primary
bioactive
constituents
responsible
for
various
health
benefits
of
tea,
can
be
categorized
into
different
subgroups
according
to
their
structural
characteristics.
However,
distinctions
in
antiviral
activity
among
diverse
types
polyphenolic
compounds
remain
unexplored.
In
present
study,
fifty-eight
tea
polyphenols
with
varied
structures,
including
eleven
undescribed
compounds,
were
isolated
from
Rougui
Wuyi
rock
tea.
Their
molecular
structures
elucidated
using
comprehensive
analytical
approaches
NMR,
HRMS,
CD
spectroscopic
data
and
acid
hydrolysis.
The
polyphenol
analogs
could
structurally
classified
two
main
categories:
flavan-3-ols,
which
include
catechins,
flavoalkaloids,
procyanidins
theasinensins,
flavones,
encompassing
kaempferol,
quercetin,
myricetin,
respective
glycosides.
inhibitory
activities
against
3CLpro
assessed
vitro,
eighteen
phenolic
exhibited
effects
on
3CLpro,
IC50
values
ranging
9.8
μM
61.1
μM.
Among
them,
catechin
flavoalkaloid
derivatives,
demonstrated
superior
compared
other
categories.
structure-activity
relationship
was
further
explored,
docking
analysis
revealed
that
differing
derivatives
attributed
variations
number
positions
hydrogen
bond
interactions
3CLpro.
This
study
provides
a
valuable
understanding
supplies
potential
lead
drugs.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 16, 2024
Introduction
Kaempferol,
a
flavonoid
found
in
numerous
foods
and
medicinal
plants,
offers
range
of
health
benefits
such
as
anti-inflammatory,
antioxidant,
antiviral,
anticancer,
cardioprotective,
neuroprotective
effects.
Methods
Herein,
bibliometric
visual
analysis
global
publications
on
kaempferol
was
performed
to
map
the
evolution
frontiers
hotspots
field.
Using
search
string
TS
=
kaempferol,
data
for
this
extracted
from
Web
Science
Core
Collection
database
analyzed
using
VOSviewer,
CiteSpace,
Scimago
Graphica
software.
Results
As
result,
by
February
26,
2024,
11,214
were
identified,
comprising
articles
(
n
10,746,
96%)
review
468,
4%).
Globally,
annual
number
surpassed
100
per
year
since
2000,
exceeded
500
2018,
further
crossed
threshold
1,000
starting
2022.
The
major
contributing
countries
China,
United
States
America,
India,
while
top
three
institutes
citations
Chinese
Academy
Sciences,
Consejo
Superio
de
Investigaciones
Cientficas,
Uniersidade
do
Porto.
These
mainly
published
agricultural
food
chemistry
journals,
chemistry,
phytochemistry.
Discussion
keywords
frequently
mentioned
include
phenolic
compounds,
antioxidant
activity,
flavonoids,
NF-kappa
B,
inflammation,
bioactive
etc.
Anti-inflammation,
anti-oxidation,
anti-cancer
have
consistently
been
focus
research,
cardiovascular
protection,
neuroprotection,
anti-bacterial
effects
emerged
recent
highlights.
field
research
is
thriving.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 10, 2024
Intestinal
stem
cells
(ISCs)
are
crucial
for
tissue
repair
and
homeostasis
because
of
their
ability
to
self-renew
differentiate.
However,
functionality
declines
significantly
with
age,
resulting
in
reduced
regeneration
a
higher
risk
age-related
diseases.
Addressing
this
decline
ISC
performance
during
aging
presents
substantial
challenge.
The
specific
impact
nutrients
or
dietary
elements
on
adaptive
resizing
is
urgent
explore.
Horticulturae,
Journal Year:
2023,
Volume and Issue:
9(10), P. 1111 - 1111
Published: Oct. 8, 2023
This
study
employed
the
mixture
design
method
to
determine
optimal
solvent
combinations,
aiming
obtain
refined
extracts
from
squash
peels
with
enhanced
antioxidant
properties.
We
optimized
extraction
solvents,
focusing
on
recovering
total
phenolic
compounds
(TPC)
and
increased
properties
using
a
second-order
polynomial
equation
through
response
surface
methodology
(RSM).
Six
solvents
(MeOH,
Hexane,
DCM,
EtOAc,
BuOH,
water)
were
assessed
for
their
effects
TPC
activity
in
preliminary
experiments.
The
underwent
HPLC
analysis
composition
determination
further
evaluated
antibacterial
cytotoxicity.
results
revealed
rich
content
extract
of
Bejaoui
landrace,
primarily
catechin
(8.06
mg/g
dry
(DE)),
followed
by
epicatechin
kaempferol
(5
DE).
Antibacterial
tests
against
Enterococcus
faecalis,
Pseudomonas
aeruginosa,
Salmonella
typhimurium,
Staphylococcus
aureus
showed
significant
antimicrobial
activities,
especially
Karkoubi
batati
landraces,
where
growth
inhibitions
99%,
96%,
97%,
80%
94%,
89%,
98%,
96%
respective
bacteria.
peel
exhibited
negligible
cytotoxicity
RAW264.7
cell
line,
even
at
high
concentrations.
Our
findings
emphasize
potential
due
diverse
compounds,
suggesting
use
food
nutraceuticals
industries
as
sources
natural
agents.
