Cuproptosis: mechanisms and links with cancers

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 7, 2023

Abstract Cuproptosis was a copper-dependent and unique kind of cell death that separate from existing other forms death. The last decade has witnessed considerable increase in investigations programmed death, whether copper induced an independent form long been argued until mechanism cuproptosis revealed. After that, increasing number researchers attempted to identify the relationship between process cancer. Thus, this review, we systematically detailed systemic cellular metabolic processes copper-related tumor signaling pathways. Moreover, not only focus on discovery its mechanism, but also outline association cancers. Finally, further highlight possible therapeutic direction employing ion ionophores with cuproptosis-inducing functions combination small molecule drugs for targeted therapy treat specific

Language: Английский

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Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116115 - 116115

Published: Jan. 5, 2024

Ferroptosis and cuproptosis, regulated forms of cell death resulting from metal ion accumulation, are closely related in terms occurrence, metabolism, signaling pathways, drug resistance. Notably, it is now understood that these processes play crucial roles regulating physiological pathological processes, especially tumor development. Consequently, ferroptosis cuproptosis have gained increasing significance as potential targets for anti-cancer This article systematically outlines the molecular mechanisms cross-talk components both elucidating their impacts on cancer. Furthermore, investigates clinical perspective targeted cancer chemotherapy, immunotherapy, radiotherapy. Our discussion extends to a comparative analysis nanoparticles developed based cancer, contrasting them with current conventional therapies. Opportunities challenges treatment explored, emphasizing therapeutic direction co-targeting cuproptosis. The also attempts analyze applications this approach while summarizing existing barriers require overcoming.

Language: Английский

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Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insights

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27496 - e27496

Published: March 1, 2024

Copper, a vital trace element, orchestrates diverse cellular processes ranging from energy production to antioxidant defense and angiogenesis. Copper metabolism cuproptosis are closely linked in the context of human diseases, with particular focus on cancer. Cuproptosis refers specific type copper-mediated cell death or copper toxicity triggered by disruptions within cells. This phenomenon encompasses spectrum mechanisms, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum perturbations metal ion equilibrium. Mechanistically, is driven binding lipoylated enzymes tricarboxylic acid (TCA) cycle. interaction participates protein aggregation proteotoxic ultimately culminating death. Targeting its associated pathways cancer cells holds therapeutic potential selectively targeting eliminating cancerous Strategies modulate levels, enhance excretion, interfere cuproptotic being explored identify novel targets for therapy improve patient outcomes. Understanding relationship between malignancies remains an active area research. review provides comprehensive overview association metabolism, homeostasis, cancers, explicitly emphasizing mechanism implications pathogenesis. Additionally, we emphasize aspects treatment.

Language: Английский

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A novel basement membrane-related gene signature for prognosis of lung adenocarcinomas

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 154, P. 106597 - 106597

Published: Jan. 24, 2023

Lung adenocarcinoma (LUAD) remains a global health concern with its poor prognosis and high mortality. Whether tumor cells invade through the basement membrane (BM) is key factor to determine of LUAD. This study aimed identify BM-related gene signatures improve overall LUAD.A series bioinformatics analyses were conducted based on TCGA GEO datasets. Unsupervised consistent cluster analysis was performed, 500 LUAD patients assigned two different groups according expressions 222 genes. The differentially expressed genes (DEGs) between clusters identified, Lasso regression, ROC curve, univariate multivariate Cox regression enrichment conducted. Besides, ssGSEA, CIBERSORT ESTIMATE algorithmwere employed understand relationship microenvironment (TME) risk scores. Moreover, single cell clustering trajectory performed further significance Finally, qRT-PCR used verify model.A total 31 prognostic determined for LUAD, novel 17-mRNA model named BMsocre successfully established predict survival patients. BMscore group indicated worse prognosis. Seventeen DEGs enriched mainly in metabolism, ECM-receptor interaction immune response. In addition, high-risk showed higher TMB lower score. low-risk had better immunotherapeutic response where escape less likely. verified our patient cohort. Furthermore, NELL2 T cells, identified play critical role T-cell differentiation.A might be effective providing guidance therapy.

Language: Английский

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Machine learning and molecular subtyping reveal the impact of diverse patterns of cell death on the prognosis and treatment of hepatocellular carcinoma

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 115, P. 108360 - 108360

Published: Jan. 27, 2025

Language: Английский

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The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.

Language: Английский

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Mendelian Randomization Validates the Immune Landscape Mediated by Aggrephagy in Esophageal Squamous Cell Carcinoma Patients from the Perspectives of Multi-omics

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(7), P. 1940 - 1953

Published: Jan. 1, 2024

To delineate the immune landscape of ESCC patients mediated by aggrephagy through bioinformatics and identify prognostic cell cluster genes with causal attributes to esophageal cancer Mendelian randomization.

Language: Английский

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Cuproptosis in microsatellite stable colon cancer cells affects the cytotoxicity of CD8+T through the WNT signaling pathway

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 403, P. 111239 - 111239

Published: Sept. 19, 2024

Language: Английский

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Copper homeostasis and cuproptosis in central nervous system diseases

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 20, 2024

Abstract Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array fundamental metabolic processes. The human body maintains relatively low concentration copper, which is mostly found in bones, liver, and brain. Despite its concentration, Cu plays crucial role as element progression pathogenesis central nervous system (CNS) diseases. Extensive studies have been conducted recent years on copper homeostasis copper-induced cell death CNS disorders, including glioma, Alzheimer’s disease, Amyotrophic lateral sclerosis, Huntington’s stroke. Cuproptosis, novel pathway distinct from apoptosis, necrosis, pyroptosis, ferroptosis, has identified potentially intricately linked pathogenic mechanisms underlying various Therefore, systematic review cuproptosis their relationship with disorders could deepen our understanding these In addition, it may provide new insights strategies treatment disorders.

Language: Английский

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Machine learning predicts cuproptosis-related lncRNAs and survival in glioma patients

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 27, 2024

Language: Английский

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