Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(7)
Published: April 5, 2024
Biomaterials
denoting
self-healing
and
versatile
structural
integrity
are
highly
curious
in
the
biomedicine
segment.
The
injectable
and/or
printable
3D
printing
technology
is
explored
a
few
decades
back,
which
can
alter
their
dimensions
temporarily
under
shear
stress,
showing
potential
healing/recovery
tendency
with
patient-specific
intervention
toward
development
of
personalized
medicine.
Thus,
hydrogels
(IHs)
stunning
developing
paradigm
for
tissue
regeneration.
This
review
comprises
designing
IHs,
rheological
characterization
stability,
several
benchmark
consequences
translation
into
regeneration
specific
types,
applications
IHs
biomedical
such
as
anticancer
immunomodulation,
wound
healing
tissue/bone
regeneration,
antimicrobial
potentials,
drugs,
gene
vaccine
delivery,
ocular
printing,
cosmeceuticals,
photothermal
therapy
well
other
allied
avenues
like
agriculture,
aerospace,
electronic/electrical
industries,
coating
approaches,
patents
associated
therapeutic/nontherapeutic
avenues,
numerous
futuristic
challenges
solutions.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(27), P. 30480 - 30492
Published: April 25, 2022
Microenvironment-responsive
hydrogels
present
high
potential
in
treating
refractory
wounds
due
to
their
capability
of
on-demand
drug
release.
In
this
study,
a
specially
designed
hydrogel
with
smart
targeting
wound
characteristics
was
treat
chronically
infected
diabetic
wounds.
Aminated
gelatin
reacted
oxidized
dextran,
forming
cross-linked
dynamic
Schiff
base,
which
is
sensitive
the
low-pH
environment
Nano-ZnO
loaded
into
for
killing
microbes.
A
Paeoniflorin-encapsulated
micelle
ROS-responsive
property
fixed
skeleton
via
base
bond
low-pH-
and
ROS-stimulated
angiogenic
activity.
The
sequential
responsiveness
novel
enabled
rescue
deleterious
microenvironment
This
highly
biocompatible
demonstrated
antibacterial
abilities
vitro
significantly
promoted
healing
hemostatic,
microbe
killing,
activities.
microenvironment-responsive
nZnO
Pf-encapsulated
micelles
holds
great
as
location-specific
dual-response
delivery
platform
curing
refractory,
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: June 2, 2024
Abstract
Hydrogels
are
dynamically
evolving
3D
networks
composed
of
hydrophilic
polymer
scaffolds
with
significant
applications
in
the
healthcare
and
environmental
sectors.
Notably,
protein‐based
hydrogels
mimic
extracellular
matrix,
promoting
cell
adhesion.
Further
enhancing
proliferation
within
these
matrix‐metalloproteinase‐triggered
amino
acid
motifs.
Integration
cell‐friendly
modules
like
peptides
proteins
expands
hydrogel
functionality.
These
exceptional
properties
position
for
diverse
applications,
including
biomedicine,
biosensors,
remediation,
food
industry.
Despite
progress,
there
is
ongoing
research
to
optimize
biomedical
further.
Engineering
novel
favorable
characteristics
crucial
regulating
tissue
architecture
facilitating
ecological
remediation.
This
review
explores
synthesis,
physicochemical
properties,
biological
implications
various
types
their
extensive
biomedicine
It
elaborates
on
potential
bridging
gap
between
advancements
sector
solutions
issues.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
33, P. 506 - 531
Published: Dec. 8, 2023
Intervertebral
disc
degeneration
(IVDD)
is
rising
worldwide
and
leading
to
significant
health
issues
financial
strain
for
patients.
Traditional
treatments
IVDD
can
alleviate
pain
but
do
not
reverse
disease
progression,
surgical
removal
of
the
damaged
may
be
required
advanced
disease.
The
inflammatory
microenvironment
a
key
driver
in
development
degeneration.
Suitable
anti-inflammatory
substances
are
critical
controlling
inflammation
IVDD.
Several
treatment
options,
including
glucocorticoids,
non-steroidal
drugs,
biotherapy,
being
studied
their
potential
reduce
inflammation.
However,
anti-inflammatories
often
have
short
half-life
when
applied
directly
quickly
excreted,
thus
limiting
therapeutic
effects.
Biomaterial-based
platforms
explored
as
anti-inflammation
strategies
treatment.
This
review
introduces
pathophysiology
discusses
therapeutics
components
these
unique
biomaterial
comprehensive
systems.
We
discuss
strengths,
shortcomings,
prospects
various
biomaterials
used
modulate
microenvironment,
providing
guidance
future
breakthroughs
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 20, 2023
Abstract
Chronic
inflammatory
diseases,
such
as
intervertebral
disc
degeneration
(IVDD),
which
affect
the
lives
of
hundreds
millions
people,
still
lack
effective
and
precise
treatments.
In
this
study,
a
novel
hydrogel
system
with
many
extraordinary
properties
is
developed
for
gene–cell
combination
therapy
IVDD.
Phenylboronic
acid‐modified
G5
PAMAM
(G5‐PBA)
first
synthesized,
therapeutic
siRNA
silencing
expression
P65
mixed
G5‐PBA
(siRNA@G5‐PBA)
then
embedded
into
(siRNA@G5‐PBA@Gel)
based
on
multi‐dynamic
bonds
including
acyl
hydrazone
bonds,
imine
linkage,
π
–
stacking,
hydrogen
bonding
interactions.
Local
acidic
microenvironment‐responsive
gene‐drug
release
can
achieve
spatiotemporal
regulation
gene
expression.
addition,
from
be
sustained
more
than
28
days
in
vitro
vivo,
greatly
inhibiting
secretion
factors
subsequent
nucleus
pulposus
(NP)
cells
induced
by
lipopolysaccharide
(LPS).
Through
prolonged
inhibition
P65/NLRP3
signaling
pathway,
siRNA@G5‐PBA@Gel
verified
to
relieve
storms,
significantly
enhance
regeneration
IVD
when
combined
cell
therapy.
Overall,
study
proposes
an
innovative
minimally
invasive
treatment
method
regeneration.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 26, 2024
Abstract
Tissue
regeneration
technology
has
been
rapidly
developed
and
widely
applied
in
tissue
engineering
repair.
Compared
with
traditional
approaches
like
surgical
treatment,
the
rising
gene
therapy
is
able
to
have
a
durable
effect
on
regeneration,
such
as
impaired
bone
articular
cartilage
repair
cancer-resected
Gene
can
also
facilitate
production
of
situ
therapeutic
factors,
thus
minimizing
diffusion
or
loss
complexes
enabling
spatiotemporally
controlled
release
products
for
regeneration.
Among
different
delivery
vectors
supportive
gene-activated
matrices,
advanced
gene/drug
nanocarriers
attract
exceptional
attraction
due
their
tunable
physiochemical
properties,
well
excellent
adaptive
performance
bone,
cartilage,
blood
vessel,
nerve
This
paper
reviews
recent
advances
nonviral-mediated
systems
an
emphasis
important
role
