A Novel Hydrogel Sponge for Three-Dimensional Cell Culture DOI Creative Commons
Sara Baldassari, Mengying Yan, Giorgia Ailuno

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1341 - 1341

Published: Oct. 19, 2024

Three-dimensional (3D) cell culture technologies allow us to overcome the constraints of two-dimensional methods in different fields like biochemistry and biology pharmaceutical vitro tests. In this study, a novel 3D hydrogel sponge scaffold, composed crosslinked polyacrylic acid forming porous matrix, has been developed characterized.

Language: Английский

Smart biomaterial gels for periodontal therapy: A novel approach DOI Open Access

Rabia Ashfaq,

Anita Kovács, Szilvia Berkó

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117836 - 117836

Published: Jan. 19, 2025

Language: Английский

Citations

1
Advances in natural polymer-based hydrogels: synthesis, applications, and future directions in biomedical and environmental fields DOI Creative Commons

Debasis Nanda,

Diptiranjan Behera,

Shruti S. Pattnaik

et al.

Discover Polymers., Journal Year: 2025, Volume and Issue: 2(1)

Published: March 20, 2025

Language: Английский

Citations

1
Novel Supramolecular Hydrogel for Infected Diabetic Foot Ulcer Treatment DOI Open Access
Wenbiao Zhang, Weiwei Wu, Tao Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Multifunctional responsive hydrogels hold significant promise for diabetic foot ulcer (DFU) treatment, though their complex design and manufacturing present challenges. This study introduces a novel supramolecular guanosine‐phenylboronic‐chlorogenic acid (GBC) hydrogel developed using dynamic covalent strategy. The forms through guanosine quadruplex assembly in the presence of potassium ions chlorogenic (CA) linkage via borate bonds. GBC exhibit pH glucose responsiveness, releasing more under acidic high conditions due to bond dissociation G‐quadruplex (G4) disintegration. Experimental results indicate that good self‐healing, shear‐thinning, injectability, swelling properties. Both vitro vivo studies demonstrate hydrogel's biocompatibility, ability eliminate bacteria reactive oxygen species (ROS), facilitate macrophage polarization from M1 phenotype M2 (decreasing CD86 expression increasing CD206 expression), anti‐inflammatory effects (reducing TNF‐α IL‐10 promote angiogenesis (increasing VEGF, CD31, α‐SMA expression). Thus, accelerate DFU healing enhance tissue remodeling collagen deposition. work provides new approach developing expedite healing.

Language: Английский

Citations

5
Advances in sensing technologies using functional carbon nanotube-hydrogel nanocomposites DOI
Mansour A.S. Salem,

Aadil Shafi Bhat,

Rabiya Mehandi

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114139 - 114139

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanohydrogel mediated approaches for wound healing DOI
Ashkan Farazin, Fatemeh Rajabi

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 138

Published: Jan. 1, 2025

Language: Английский

Citations

0
Hybrid silica–sodium lignosulfonate nanoparticles for the controlled release of azadirachtin DOI
Carlos A. Busatto,

Adriano Bruzzoni,

María Eugenia Taverna

et al.

Iranian Polymer Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Language: Английский

Citations

0
Effects of hydrogel stiffness and viscoelasticity on organoid culture: a comprehensive review DOI Creative Commons
Lai Wei,

Hu Geliang,

Bin Xu

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 3, 2025

Abstract As an emerging technology, organoids are promising new tools for basic and translational research in disease. Currently, the culture of relies mainly on a type unknown composition scaffold, namely Matrigel, which may pose problems studying effect mechanical properties organoids. Hydrogels, material with adjustable properties, can adapt to current studies. In this review, we summarized synthesis recent advance developing definite hydrogel scaffolds organoid identified critical parameters regulating properties. addition, classified by different like stiffness viscoelasticity, concluded development tumor We hope review enhances understanding hydrogels provides more practical approaches investigating them.

Language: Английский

Citations

0
Nanocomposites for Bone Tissue Engineering Application DOI
Monalisha Mallick,

Ramakrishna Prasad Are,

Anju R. Babu

et al.

Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100261 - 100261

Published: March 1, 2025

Language: Английский

Citations

0
Strategies for Fabricating Multi-Material Bone Tissue Constructs DOI
Yusuf Olatunji Waidi

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00405 - e00405

Published: March 1, 2025

Language: Английский

Citations

0
ROS‐Activated Nanohydrogel Scaffolds with Multi‐Factors Controlled Release for Targeted Dual‐Lineage Repair of Osteochondral Defects DOI Creative Commons
Xiuhui Wang,

Shunli Wu,

Ruiyang Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Abstract Achieving self‐healing for osteochondral defects caused by trauma, aging, or disease remains a significant challenge in clinical practice. It is an effective therapeutic strategy to construct gradient‐biomimetic biomaterials that replicate the hierarchical structure and complex microenvironment of tissues dual‐lineage regeneration both cartilage subchondral bone. Herein, ROS‐activated nanohydrogels composite bilayer scaffolds with multi‐factors controlled release are rationally designed using combination 3D printing gelatin placeholder methods. The resulting nanohydrogel exhibit micro‐nano interconnected porous soft‐hard mechanical strength facilitating culture BMSCs vitro. More importantly, multi‐stage continuous responses anti‐inflammation, chondrogenesis osteogenesis, effectively induced via sequential multi‐factors, including diclofenac sodium (DS), kartogenin (KGN) bone morphogenetic protein 2 (BMP‐2), from scaffolds, thereby improved tissue defect model SD rats. These findings suggest such specific delivery functional factors, provides promising defects.

Language: Английский

Citations

0