Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Small Methods, Journal Year: 2022, Volume and Issue: 6(8)

Published: June 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Language: Английский

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Bone/cartilage targeted hydrogel: Strategies and applications

Bioactive Materials, Journal Year: 2022, Volume and Issue: 23, P. 156 - 169

Published: Nov. 11, 2022

The skeletal system is responsible for weight-bearing, organ protection, and movement. Bone diseases caused by trauma, infection, aging can seriously affect a patient's quality of life. targeted biomaterials are suitable the treatment bone diseases. Biomaterials with bone-targeted properties improve drug utilization reduce side effects. A large number micro-nano materials have been developed. However, only few studies addressed hydrogel. size hydrogel makes it difficult to achieve systematic targeting. local still has significant prospects. Molecules in bone/cartilage extracellular matrix cells provide binding sites Drug delivery systems featuring microgels targeting key construction strategy Besides, injectable depot carrying drugs another strategy. In this review, we summarize through application environment, strategies disease applications. We hope article will reference development hydrogels. also could increase awareness materials.

Language: Английский

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Silk fibroin-based biomaterials for cartilage/osteochondral repair

Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 5103 - 5124

Published: Jan. 1, 2022

Osteoarthritis (OA) is a common joint disease with high disability rate.In addition, OA not only causes great physiological and psychological harm to patients, but also puts pressure on the social healthcare system.Pathologically, disintegration of cartilage lesions subchondral bone are related OA.Currently, tissue engineering, which expected overcome defects existing treatment methods, had lot research in field cartilage/osteochondral repair.Silk fibroin (SF), as natural macromolecular material good biocompatibility, unique mechanical properties, excellent processability degradability, holds potential engineering.Nowadays, SF been prepared into various materials adapt demands repair.SF-based biomaterials can be functionally modified enhance repair performance further.In this review, preparation types, structures, functional modifications SF-based used for summarized discussed.We hope that review will provide reference design development field.

Language: Английский

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Bone Repair Biomaterials: A Perspective from Immunomodulation

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(51)

Published: Oct. 9, 2022

Abstract With an increasingly aging society, bone defects and fractures have become significant threats to human health quality of life. Currently, autologous allogeneic grafts remain the “gold standard” for clinical treatment repair. However, transplantation is still clinically insufficient, owing its substantial limitations, such as graft rejection, donor functional defects, risk infection. Therefore, a variety biomaterials been developed facilitate advancement tissue engineering, focus research has transitioned from bioinert bioactive biomaterials. many not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology revealed that immune system, which macrophages are critical components, plays essential regulatory role regeneration. this review, healing explored developments promote regeneration by modulating macrophage polarization improving osteoimmune microenvironment reviewed. This review provides reference development application repair immunomodulation perspective.

Language: Английский

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Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery

Science Advances, Journal Year: 2023, Volume and Issue: 9(25)

Published: June 21, 2023

Intratissue topical medication is important for the treatment of cutaneous, mucosal or splanchnic diseases. However, penetrating surface barriers to providing adequate and controllable drug delivery while guaranteeing adhesion in bodily fluids remains challenging. Here, predatory behavior blue-ringed octopus inspired us with a strategy improve medication. For effective intratissue delivery, active injection microneedles were prepared manner by teeth venom secretion octopus. With on demand release function guided temperature-sensitive hydrophobic shrinkage variations, these can supply at an early stage then achieve long-term stage. Meanwhile, bionic suction cups developed facilitate stay firmly place (>10 kilopascal) when wet. wet bonding ability multiple mode, this microneedle patch achieved satisfactory efficacy, such as accelerating ulcers' healing speed halting tumor progression.

Language: Английский

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Synthesis and characterization of g–C3N4–CoFe2O4–ZnO magnetic nanocomposites for enhancing photocatalytic activity with visible light for degradation of penicillin G antibiotic

Environmental Research, Journal Year: 2022, Volume and Issue: 215, P. 114270 - 114270

Published: Sept. 11, 2022

Language: Английский

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Targeted and responsive biomaterials in osteoarthritis

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 931 - 954

Published: Jan. 1, 2023

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions tissue lesions.The non-vascular environment dense matrix in the joints tend to block drug penetration, resulting low bioavailability.There desire develop safer more effective OA therapies meet challenges an aging world population future.Biomaterials have achieved satisfactory results improving targeting, prolonging duration action, achieving precision therapy.This article reviews current basic understanding pathological mechanisms clinical treatment dilemmas OA, summarizes discusses advances for different kinds targeted responsive biomaterials seeking provide new perspectives OA.Subsequently, limitations translation biosafety are analyzed guide development future therapeutic strategies OA.As need medicine rises over time, emerging multifunctional based on targeting controlled release will become irreplaceable part management.

Language: Английский

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Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages implants. Smart hydrogels that respond internal external stimuli achieve therapeutic actions in spatially temporally controlled manner have recently attracted much attention for therapy regeneration. These can be modified by introducing responsive moieties embedding nanoparticles increase their capacity repair. Under specific stimuli, smart variable, programmable, controllable changes on demand modulate the microenvironment promoting healing. In this review, we highlight advantages summarize materials, gelation methods, properties. Then, overview recent advances developing biochemical signals, electromagnetic energy, physical including single, dual, multiple types enable physiological pathological modulating microenvironment. discuss current challenges future perspectives regarding clinical translation hydrogels.

Language: Английский

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Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 255, P. 110610 - 110610

Published: Feb. 13, 2023

Language: Английский

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Bone‐Targeted Exosomes: Strategies and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 7, 2023

Abstract As the global population ages, bone‐related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, been used to treat due their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, modified exosomes exhibit strong bone‐targeting capabilities that may improve efficacy avoid systemic side effects, demonstrating promising translational potential. However, review of bone‐targeted is still lacking. Thus, recently developed for applications in this are focused. The biogenesis regulatory functions exosomes, constructive strategies bone‐targeting, effects introduced. By summarizing developments challenges It striven shed light on selection exosome different bone highlight potential future clinical orthopedics.

Language: Английский

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