Hydrogel/nanofibrous membrane composites with enhanced water retention, stretchability and self-healing capability for wound healing

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 257, P. 110672 - 110672

Published: March 17, 2023

Language: Английский

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Supramolecular hydrogels for wound repair and hemostasis

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 37 - 101

Published: Oct. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Language: Английский

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Advances in Functional Hydrogel Wound Dressings: A Review

Polymers, Journal Year: 2023, Volume and Issue: 15(9), P. 2000 - 2000

Published: April 23, 2023

One of the most advanced, promising, and commercially viable research issues in world hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition merits ordinary dressings, functional dressings can adjust their chemical/physical properties satisfy different types, carry out corresponding reactions actively create a healing environment conducive repair, also control drug release provide long-lasting benefit. Although lot in-depth has been conducted over last few decades, very studies have properly summarized. order give researchers basic blueprint for designing motivate them develop ever-more we summarized development recent years, as well current situation future trends, light preparation mechanisms effects.

Language: Английский

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Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 2, 2024

Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.

Language: Английский

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Deciphering structural biological materials: Viewing from the mechanics perspective and their prospects

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 245, P. 110213 - 110213

Published: Aug. 17, 2022

Language: Английский

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Asymmetric “Janus” Biogel for Human‐Machine Interfaces

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(34)

Published: May 11, 2023

Abstract Human‐machine interfaces (HMIs) are essential for effective communication between machines and tissues. However, mechanical biological mismatches, along with weak adhesion rigid electronic devices soft tissue, often cause unreliable responses affect the signal recording of HMIs. In this study, an asymmetrical “Janus” biogel patch one side firmly adhering to tissues, other surface having little minimal interactions surrounding environments has been developed. A series analytical, mechanical, electrical tests performed investigate as a functional biocompatible HMI. It is found that gallic acid‐modified gelatin adhesive on exhibits body temperature‐dependent tissue adhesion, enabling low modulus seamless skin contact. The tough gelatin/glycerol gel layer, which thermally welded into layer functions encapsulant prevent external interference due adhesion. encapsulation also friction coefficient when wet proves be reliable alternative barrier conventional materials. scientific insights engineering principles revealed in type will applicable broad range biomedical applications, such epidermal electrodes or skin‐adhesive wearable devices.

Language: Английский

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Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(36), P. 42304 - 42316

Published: Aug. 30, 2023

It remains challenging to fabricate highly stretchable and adhesive hydrogel dressings for wound healing using simple, safe, green methods. Herein, inspired by the main components of snail mucus, a fully physical double-network (DN) dressing composed fish gelatin (FGel) glycyrrhizic acid (GL) was fabricated, in which FGel provided protein scaffold mimic mucus proteins, while GL mimicked adhesion bioactivity because its abundant carboxyl hydroxyl groups intrinsic immunomodulatory activity. As expected, obtained FGel/GL exhibited outstanding mechanical performances (flexibility, stretchability, ability, removability), high transparency, good antifreezing properties. More importantly, they also possessed excellent biocompatibility, cell migration, angiogenesis ability vitro experiments. Finally, animal experiments vivo indicated that significantly promoted full-thickness healing, including promoting granulation tissue formation, collagen deposition, skin inhibiting inflammatory response. All these findings have great potential applications clinical treatment healing.

Language: Английский

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Polysaccharide hydrogel containing silver nanoparticle@catechol microspheres with photothermal, antibacterial and anti-inflammatory activities for infected-wounds repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130898 - 130898

Published: March 19, 2024

Language: Английский

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Gelatin/PVP/hydroxyapatite nanocomposite based on double micro-emulsion for tissue engineering applications

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 401, P. 124741 - 124741

Published: April 12, 2024

Language: Английский

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Multi-role conductive hydrogels for flexible transducers regulated by MOFs for monitoring human activities and electronic skin functions

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(25), P. 6190 - 6202

Published: Jan. 1, 2024

Metal organic frameworks (MOFs) have garnered significant attention in the development of stretchable and wearable conductive hydrogels for flexible transducers. However, MOFs used hydrogel networks been hampered by low mechanical performance poor dispersibility aqueous solutions, which affect hydrogels, including toughness, limited self-recovery, short working ranges, conductivity, prolonged response-recovery times. To address these shortcomings, a novel approach was adopted micelle co-polymerization

Language: Английский

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