Rapid Endothelialization Enabled by Integrating Bi-oriented Topography and Salvianolic Acid B Modification on a Small-Diameter Fibrous Graft

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112163 - 112163

Published: Jan. 1, 2025

Language: Английский

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A Simple and Low-cost Method to Develop Porous Egg White Scaffolds with Controllable Shape for Cartilage Regeneration

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112192 - 112192

Published: Feb. 1, 2025

Language: Английский

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An injectable antibacterial wet-adhesive for meniscal cartilage regeneration via immune homeostasis mediated by SMSC-derived extracellular vesicles

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 291, P. 111970 - 111970

Published: Nov. 12, 2024

Language: Английский

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Complex hydrogel for cartilage regeneration and anti-inflammation

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 280, P. 111481 - 111481

Published: April 24, 2024

With the increasing incidence of osteoarthritis (OA) in elderly patients and challenges posed by its multifaceted pathogenesis developing effective treatments, this study explores protein loading mode Progranulin (PGRN) therapeutic potential for treating OA. GelMA hydrogels prepared with different concentrations PGRN, employing AC-PEG-NHS as a crosslinking agent drug encapsulation, were used to test sustained release effect composite hydrogel delivery system. Additionally, we conducted vitro assays investigate regulatory effects on rat bone marrow mesenchymal atromal cells (BMSCs), chondrocytes, mouse macrophages - focusing cell proliferation, differentiation. For vivo studies, histological staining techniques utilized assess inflammatory polarization cartilage repair knee injury model. The results demonstrated that PGRN-loaded significantly accelerated enhance differentiation BMSCs into maintained healthy chondrocyte phenotype, induce M2-type while inhibiting M1-type macrophages. Histological analyses also showed markedly improved tissue group treated GelMA–NHS–PGRN hydrogels. As result, these present promising approach OA, potentially mitigating chronic inflammation facilitating through controlled PGRN. Osteoarthritis, Anti-inflammatory hydrogels, Cartilage regeneration.

Language: Английский

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Biphasic biomimetic scaffolds based on a regionally decalcified bone framework and pre-chondrogenic microspheres for osteochondral defect repair

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101494 - 101494

Published: Jan. 13, 2025

Osteochondral defects are still facing a significant challenge in clinical surgery, making post-trauma repair difficult. Tissue engineering has provided promising approach to solving these defects. However, existing scaffolds cannot replicate the complex biphasic cartilage-bone microenvironment with accuracy. We aimed develop biomimetic scaffold regionally regulated vascularization that promoted chondrogenesis and osteogenesis through bidirectional regulation of endochondral ossification. This consisted pre-chondrogenic microspheres (PCMs) decalcified bone frame prepared by decalcifying cartilage layer varying degrees. Incorporation PCMs into created regeneration while axitinib was modified inhibit enhance regeneration. The ossification facilitated repair. In vitro studies have shown axitinib-modified layers significantly VEGF expression cells, powder from promotes PCMs. vivo experiments indicated this controls regionalized angiogenesis, promoting integrated reconstruction osteochondral rabbit knee joints. These results suggest our designed demineralized can precisely engineer microenvironment, providing theoretical guidance for anisotropic tissue injuries.

Language: Английский

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Control and interplay of scaffold-biomolecules interactions applied to cartilage tissue engineering.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cartilage tissue engineering based on the combination of biomaterials, adult or stem cells and bioactive factors is a challenging approach for regenerative medicine with aim achieving formation functional neotissue stable in long term. Various 3D scaffolds have been developed to mimic extracellular matrix environment promote cartilage repair. In addition, extensively employed induce maintain phenotype. However, spatiotemporal control factor release remains critical maximizing potential multipotent cells, such as mesenchymal stromal (MSCs), efficient chondrogenesis sustained homeostasis, which are essential repair hyaline cartilage. Despite advances, effective delivery limited by challenges insufficient retention at site injury loss therapeutic efficacy due uncontrolled drug release. These limitations prompted research biomolecule-scaffold interactions develop advanced systems that provide controlled bioavailability biological factors, thereby improving outcomes. This review focuses specifically biomaterials (natural, hybrid synthetic) biomolecules (molecules, proteins, nucleic acids) interest engineering. Herein, we detail approaches their release, chemical nature structure, through steric, non-covalent and/or covalent interactions, view application

Language: Английский

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Diphasic integrated 3D-bioprinting strategy using framework-enhanced porous cartilage-specific matrix hydrogels for augmentation rhinoplasty

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162441 - 162441

Published: April 1, 2025

Language: Английский

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Micro-structure modified decalcified bone matrix scaffolds and bone marrow stem cell–chondrocyte co-cultures promote stable cartilage regeneration

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 291, P. 111976 - 111976

Published: Nov. 16, 2024

Language: Английский

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