Circuit modules linking internal states and social behaviour in flies and mice

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(11), P. 692 - 704

Published: Oct. 18, 2016

Language: Английский

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Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 179, P. 101607 - 101607

Published: March 22, 2019

Language: Английский

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A Model for Basic Emotions Using Observations of Behavior in Drosophila

Frontiers in Psychology, Journal Year: 2019, Volume and Issue: 10

Published: April 24, 2019

Emotion plays a crucial role, both in general human experience and psychiatric illnesses. Despite the importance of emotion, relative lack objective methodologies to scientifically studying emotional phenomena limits our current understanding thereby calls for development novel methodologies, such us study illustrative animal models. Analysis Drosophila other insects has unlocked new opportunities elucidate behavioral phenotypes fundamentally phenomena. Here we propose an integrative model basic emotions based on observations this model. The are internal states that modulated by neuromodulators, these externally expressed as certain stereotypical behaviors, instinct, which is proposed ancient mechanisms survival. There four kinds emotions: happiness, sadness, fear anger, differentially associated with three core affects: reward (happiness), punishment (sadness), stress (fear anger). These affects analogous primary colors (red, yellow, blue) they combined various proportions result more complex "higher order" emotions, love aesthetic emotion. We refer called "Three Primary Color Model Basic Emotions".

Language: Английский

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Gut microbiome modulates Drosophila aggression through octopamine signaling

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 11, 2021

Abstract Gut microbiome profoundly affects many aspects of host physiology and behaviors. Here we report that gut modulates aggressive behaviors in Drosophila . We found germ-free males showed substantial decrease inter-male aggression, which could be rescued by microbial re-colonization. These are not as competitive wild-type for mating with females, although they displayed regular levels locomotor courtship further interacted diet during a critical developmental period the proper expression octopamine manifestation aggression adult males. findings provide insights into how specific through interaction development.

Language: Английский

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Descending networks transform command signals into population motor control

Nature, Journal Year: 2024, Volume and Issue: 630(8017), P. 686 - 694

Published: June 5, 2024

Abstract To convert intentions into actions, movement instructions must pass from the brain to downstream motor circuits through descending neurons (DNs). These include small sets of command-like that are sufficient drive behaviours 1 —the circuit mechanisms for which remain unclear. Here we show DNs in Drosophila directly recruit networks additional orchestrate require active control numerous body parts. Specifically, found previously thought alone 2–4 fact co-activate larger populations DNs. Connectome analyses and experimental manipulations revealed this functional recruitment can be explained by direct excitatory connections between interconnected brain. Descending population is necessary behavioural control: with many partners network co-activation complete only simple stereotyped movements their absence. DN reside within behaviour-specific clusters inhibit one another. results support a mechanism generated increasingly large compose combining multiple subroutines.

Language: Английский

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Cell types and neuronal circuitry underlying female aggression in Drosophila

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 3, 2020

Aggressive social interactions are used to compete for limited resources and regulated by complex sensory cues the organism's internal state. While both sexes exhibit aggression, its neuronal underpinnings understudied in females. Here, we identify a population of sexually dimorphic aIPg neurons adult Drosophila melanogaster central brain whose optogenetic activation increased, genetic inactivation reduced, female aggression. Analysis GAL4 lines identified an unbiased screen increased chasing behavior revealed involvement another neuron, pC1d, implicated pC1d as core nodes regulating Connectomic analysis demonstrated that interconnected suggest may exert part their effect gating flow visual information descending neurons. Our work reveals important regulatory components circuitry underlies aggressive provides tools manipulation.

Language: Английский

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Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila

Neuron, Journal Year: 2019, Volume and Issue: 105(2), P. 322 - 333.e5

Published: Dec. 3, 2019

Language: Английский

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A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila

Neuron, Journal Year: 2017, Volume and Issue: 95(5), P. 1112 - 1128.e7

Published: Aug. 1, 2017

Language: Английский

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Potentiation of Divergent Medial Amygdala Pathways Drives Experience-Dependent Aggression Escalation

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(25), P. 4858 - 4880

Published: May 18, 2020

Heightened aggression can be serious concerns for the individual and society at large are symptoms of many psychiatric illnesses, such as post-traumatic stress disorder. The circuit synaptic mechanisms underlying experience-induced increase, however, poorly understood. Here we find that prior attack experience leading to an increase in aggressive behavior, known priming, activates neurons within posterior ventral segment medial amygdala (MeApv). Optogenetic stimulation MeApv using a depression protocol suppresses whereas high-frequency enhances aggression, mimicking experience. Interrogation neural circuitry revealed mediates priming via connections with ventromedial hypothalamus (VmH) bed nucleus stria terminalis (BNST). These pathways undergo NMDAR-dependent potentiation after attack. Furthermore, MeApv–VmH synapses selectively control duration, MeApv–BNST modulate frequency, both no effect on social behavior. Synaptic contributes increased induced by traumatic stress, weakening transmission these blocks aggression. results reveal basis modulation potentially leveraged toward clinical interventions. SIGNIFICANCE STATEMENT have devastating consequences may associated disorders, escalation, identify two between its downstream partners, enhance Notably, circuits naturally occurring stress-induced increase. illustrate experience, which targeted

Language: Английский

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Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 23, 2021

Abstract Septal-hypothalamic neuronal activity centrally mediates aggressive behavior and dopamine system hyperactivity is associated with elevated aggression. However, the causal role of in aggression its target circuit mechanisms are largely unknown. To address this knowledge gap, we studied modulatory population- projection-specific function a murine model behavior. We find that terminal ventral tegmental area (VTA) dopaminergic neurons selectively projecting to lateral septum (LS) sufficient for promoting necessary establishing baseline Within LS, acts on D2-receptors inhibit GABAergic neurons, septal D2-signaling VTA promote Collectively, our data reveal powerful influence synaptic input LS aggression, effectively linking clinically pertinent hyper-dopaminergic classic septal-hypothalamic axis.

Language: Английский

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