Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 179, P. 101607 - 101607

Published: March 22, 2019

Language: Английский

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A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 26, 2021

Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of

Language: Английский

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Serotonin in Animal Cognition and Behavior

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(5), P. 1649 - 1649

Published: Feb. 28, 2020

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition behavior. In spite completely distinct organization the 5-HT across kingdom, lines evidence suggest influences on behavior are evolutionary conserved. this review, we have selected some behaviors classically evoked when addressing roles system functions. particular, focus motor activity, arousal, sleep circadian rhythm, feeding, social interactions aggressiveness, anxiety, mood, learning memory, or impulsive/compulsive dimension behavioral flexibility. The 5-HT, illustrated vertebrates, show more able to potentiate mitigate neuronal responses necessary fine-tuning most behaviors, rather than trigger halt specific is, therefore, prototypical fundamentally involved adaptation all organisms kingdom.

Language: Английский

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Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 43(5), P. 937 - 952

Published: Dec. 5, 2017

Language: Английский

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The Regulation of Drosophila Sleep

Current Biology, Journal Year: 2021, Volume and Issue: 31(1), P. R38 - R49

Published: Jan. 1, 2021

Language: Английский

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A potassium channel β-subunit couples mitochondrial electron transport to sleep

Nature, Journal Year: 2019, Volume and Issue: 568(7751), P. 230 - 234

Published: March 20, 2019

Language: Английский

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Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

eLife, Journal Year: 2020, Volume and Issue: 9

Published: June 8, 2020

Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, neural mechanisms coordinate these distinct programs remain poorly understood. Here, we examine how nematode C. elegans coupled together across behavioral states. We describe a new imaging platform permits automated, simultaneous quantification each main over hours or days. Analysis whole-organism profiles shows change animals switch Utilizing genetics, optogenetics, calcium imaging, identify role for dopamine in coupling locomotion egg-laying These results provide insights throughout an organism coordinated suggest neuromodulators like can couple circuits state-dependent manner.

Language: Английский

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Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep

Science Advances, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 6, 2023

Genome-wide association studies (GWAS) in humans have identified loci robustly associated with several heritable diseases or traits, yet little is known about the functional roles of underlying causal variants regulating sleep duration quality. We applied an ATAC-seq/promoter focused Capture C strategy human iPSC-derived neural progenitors to carry out a "variant-to-gene" mapping campaign that 88 candidate effector genes connected relevant GWAS signals. To functionally validate role implicated regulation, we performed neuron-specific RNA interference screen fruit fly,

Language: Английский

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Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila

Frontiers in Systems Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: March 28, 2018

Startle-induced locomotion is commonly used in Drosophila research to monitor locomotor reactivity and its progressive decline with age or under various neuropathological conditions. A widely paradigm startle-induced negative geotaxis (SING), which flies entrapped a narrow column react gentle mechanical shock by climbing rapidly upwards. Here we combined vivo manipulation of neuronal activity splitGFP reconstitution across cells search for brain neurons putative circuits that regulate this behavior. We show the specific clusters dopaminergic (DANs) afferent mushroom bodies (MBs) modulates SING, DAN-mediated SING regulation requires expression DA receptor Dop1R1/Dumb, but not Dop1R2/Damb, intrinsic MB Kenyon (KCs). confirmed our previous observation activating α'β', αβ, KCs decreased response, identified further implicated control, including γ lobe two subtypes output (MBONs). also observed co-activating αβ antagonizes α'β' KC-mediated modulation, suggesting existence subtle mechanisms between different lobes control. Overall, study contributes an emerging picture modulating appear both overlap differ from those underlying associative learning memory, sleep/wake state stress-induced hyperactivity.

Language: Английский

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Endocytosis at the Drosophila blood–brain barrier as a function for sleep

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Nov. 26, 2018

Glia are important modulators of neural activity, yet few studies link glia to sleep regulation. We find that blocking activity the endocytosis protein, dynamin, in adult Drosophila increases and enhances need, manifest as resistance deprivation. Surface comprising fly equivalent blood-brain barrier (BBB) mediate effect dynamin on sleep. Blocking surface causes ultrastructural changes, albeit without compromising integrity barrier. Supporting a role for endocytic trafficking sleep, screen Rab GTPases identifies sleep-modulating effects recycling endosome Rab11 glia. also is increased BBB during reflects need. propose through represents function

Language: Английский

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