Dissociation between phase and power correlation networks in the human brain is driven by co-occurrent bursts DOI Creative Commons
Rikkert Hindriks, Prejaas Tewarie

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: March 18, 2023

Abstract Well-known haemodynamic resting-state networks are better mirrored in power correlation than phase coupling electrophysiological data. However, what do these reflect? We address this long-outstanding question neuroscience using rigorous mathematical analysis, biophysical simulations with ground truth and application of concepts to empirical magnetoencephalography (MEG) Our derivations show that for two non-Gaussian signals, their depends on coherence, cokurtosis conjugate-coherence. Only coherence contribute MEG data, but is less affected by artefactual signal leakage mirrors networks. Simulations data may reflect co-occurrent bursting events. findings shed light the origin complementary nature suggests partly reflected co-occurent bursts neuronal activity.

Language: Английский

Neuromodulation of Brain State and Behavior DOI Open Access
David A. McCormick, Dennis Nestvogel, Biyu J. He

et al.

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 391 - 415

Published: April 6, 2020

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans animals reveal that these variations not random their nature, but may fact be due large part to rapid shifts neural, cognitive, behavioral states. Here we review recent advances the understanding waking state, how generated, they modulate neural mice humans. We propose brain has an identifiable set states through which it wanders continuously a nonrandom fashion, owing ascending modulatory fast-acting corticocortical subcortical-cortical pathways. These state provide backdrop upon operates, them is critical making progress revealing mechanisms underlying cognition behavior.

Language: Английский

Citations

248
Neurovascular coupling: motive unknown DOI
Patrick J. Drew

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(11), P. 809 - 819

Published: Aug. 19, 2022

Language: Английский

Citations

96
Brain connectomics: time for a molecular imaging perspective? DOI Creative Commons
Arianna Sala,

Aldana Lizarraga,

Silvia Paola Caminiti

et al.

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(4), P. 353 - 366

Published: Jan. 6, 2023

Language: Английский

Citations

55
The Contribution of the Vascular Architecture and Cerebrovascular Reactivity to the BOLD signal Formation across Cortical Depth DOI Creative Commons
Emiel Roefs, Wouter Schellekens, Mario Gilberto Báez‐Yáñez

et al.

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 19

Published: Jan. 1, 2024

Assessment of neuronal activity using blood oxygenation level-dependent (BOLD) is confounded by how the cerebrovascular architecture modulates hemodynamic responses. To understand brain function at laminar level, it crucial to distinguish signal contributions from those determined cortical vascular organization. Therefore, our aim was investigate purely contribution in BOLD vasoactive stimuli and compare that with neuronal-induced responses a visual task. do so, we estimated response (HRF) across depth following brief stimulations under different conditions ultrahigh-field (7 Tesla) functional (f)MRI. We acquired gradient-echo (GE)-echo-planar-imaging (EPI) BOLD, containing all vessel sizes, spin-echo (SE)-EPI for which changes predominately originate microvessels, weighting compartments. Non-neuronal were induced hypercapnia hyperoxia estimate reactivity venous cerebral volume (

Language: Английский

Citations

27
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain DOI Creative Commons
Hannah Bennett, Qingguang Zhang, Yuan-Ting Wu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 30, 2024

Abstract Aging is frequently associated with compromised cerebrovasculature and pericytes. However, we do not know how normal aging differentially impacts vascular structure function in different brain areas. Here utilize mesoscale microscopy methods vivo imaging to determine detailed changes aged murine cerebrovascular networks. Whole-brain tracing shows an overall ~10% decrease length branching density ~7% increase radii brains. Light sheet 3D immunolabeling reveals increased arteriole tortuosity of Notably, vasculature pericyte densities show selective significant reductions the deep cortical layers, hippocampal network, basal forebrain We find blood extravasation, implying blood-brain barrier Moreover, awake mice demonstrates reduced baseline on-demand oxygenation despite relatively intact neurovascular coupling. Collectively, uncover regional vulnerabilities network physiological that can mediate cognitive decline aging.

Language: Английский

Citations

23
Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis DOI
Katrina Aberizk, Esra Sefik, Qingyue Yuan

et al.

Schizophrenia Research, Journal Year: 2025, Volume and Issue: 277, P. 151 - 158

Published: March 1, 2025

Language: Английский

Citations

2
Separating vascular and neuronal effects of age on fMRI BOLD signals DOI Creative Commons
Kamen A. Tsvetanov, Richard N. Henson, James B. Rowe

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2020, Volume and Issue: 376(1815), P. 20190631 - 20190631

Published: Nov. 16, 2020

Accurate identification of brain function is necessary to understand the neurobiology cognitive ageing, and thereby promote well-being across lifespan. A common tool used investigate neurocognitive ageing functional magnetic resonance imaging (fMRI). However, although fMRI data are often interpreted in terms neuronal activity, blood oxygenation level-dependent (BOLD) signal measured by includes contributions both vascular factors, which change differentially with age. While some studies results these not well known within field therefore confounds common. Despite over 10 000 BOLD-fMRI papers on fewer than 20 have applied techniques correct for effects. neurovascular only a confound fMRI, but an important feature its own right, be assessed alongside measures ageing. We review current approaches dissociate components regional activity connectivity. highlight emerging evidence that mechanisms do simply control flow support metabolic needs neurons, form complex interactions influence health disease. This article part theme issue ‘Key relationships between non-invasive neuroimaging underlying activity’.

Language: Английский

Citations

112
Neurovascular coupling and bilateral connectivity during NREM and REM sleep DOI Creative Commons
Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Oct. 29, 2020

To understand how arousal state impacts cerebral hemodynamics and neurovascular coupling, we monitored neural activity, behavior, hemodynamic signals in un-anesthetized, head-fixed mice. Mice frequently fell asleep during imaging, these sleep events were interspersed with periods of wake. During both NREM REM sleep, mice showed large increases blood volume ([HbT]) arteriole diameter relative to the awake state, two five times larger than those evoked by sensory stimulation. NREM, amplitude bilateral low-frequency oscillations [HbT] increased markedly, coherency between activity was higher resting states. Bilateral correlations highest lowest state. Hemodynamic cortex are strongly modulated changes substantially sensory-evoked responses.

Language: Английский

Citations

98
Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response DOI
Jon̈athan R. Polimeni, Laura D. Lewis

Progress in Neurobiology, Journal Year: 2021, Volume and Issue: 207, P. 102174 - 102174

Published: Sept. 12, 2021

Language: Английский

Citations

82
nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice DOI Creative Commons
Christina Echagarruga, Kyle W. Gheres, Jordan N Norwood

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Oct. 5, 2020

Cortical neural activity is coupled to local arterial diameter and blood flow. However, which neurons control the dynamics of cerebral arteries not well understood. We dissected cellular mechanisms controlling basal evoked dilation in cortical awake, head-fixed mice. Locomotion drove robust dilation, increases gamma band power field potential (LFP), calcium signals pyramidal neuronal nitric oxide synthase (nNOS)-expressing neurons. Chemogenetic or pharmocological modulation overall up down caused corresponding decreases diameter. Modulation neuron alone had little effect on despite pronounced changes LFP. nNOS-expressing without population activity.

Language: Английский

Citations

79