Role of trigeminal ganglion satellite glial cells in masseter muscle pain hypersensitivity DOI
S. Sawada, Suzuro Hitomi, Yoshinori Hayashi

et al.

Journal of Oral Biosciences, Journal Year: 2024, Volume and Issue: unknown, P. 100596 - 100596

Published: Dec. 1, 2024

Language: Английский

Cortical astrocyte N-methyl-D-aspartate receptors influence whisker barrel activity and sensory discrimination in mice DOI Creative Commons
Noushin Ahmadpour, Meher Kantroo, Michael Stobart

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 21, 2024

Astrocytes express ionotropic receptors, including N-methyl-D-aspartate receptors (NMDARs). However, the contribution of NMDARs to astrocyte-neuron interactions, particularly in vivo, has not been elucidated. Here we show that a knockdown approach selectively reduce mouse cortical astrocytes decreases astrocyte Ca

Language: Английский

Citations

12
Immune modulation to treat Alzheimer’s disease DOI Creative Commons
Michael R. Duggan, David Morgan, Brittani R. Price

et al.

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 31, 2025

Abstract Immune mechanisms play a fundamental role in Alzheimer’s disease (AD) pathogenesis, suggesting that approaches which target immune cells and immunologically relevant molecules can offer therapeutic opportunities beyond the recently approved amyloid beta monoclonal therapies. In this review, we provide an overview of immunomodulatory therapeutics development, including their preclinical evidence clinical trial results. Along with detailing processes involved AD pathogenesis highlighting how these be therapeutically targeted to modify progression, summarize knowledge gained from previous trials immune-based interventions, series recommendations for development future treat AD.

Language: Английский

Citations

2
Multifarious astrocyte–neuron dialog in shaping neural circuit architecture DOI
Khai Huynh Ngoc,

Younghyeon Jeon,

Jaewon Ko

et al.

Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Language: Английский

Citations

8
Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase DOI Creative Commons
A. Jones,

Matilde Aquilino,

Rory J. Tinker

et al.

The American Journal of Human Genetics, Journal Year: 2024, Volume and Issue: 111(4), P. 729 - 741

Published: April 1, 2024

Language: Английский

Citations

5
Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer’s disease DOI
Mengjie Wu, Ruonan Zhang, Peng Fu

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mechanisms of astrocytic and microglial purinergic signaling in homeostatic regulation and implications for neurological disease DOI Creative Commons
Moawiah M. Naffaa

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Purinergic signaling, mediated by ATP and adenosine receptors, plays a crucial role in cellular communication homeostasis within the central nervous system (CNS), particularly regulating synaptic activity, glial cell functions, neuroplasticity. Glial cells, including astrocytes microglia, contribute to both short-term processes, such as neurotransmission neuroinflammation, long-term remodeling, tissue repair, behavioral adaptation. Dysregulation of purinergic signaling these cells has been implicated pathogenesis various neurodegenerative neuropsychiatric disorders. This article explores evolving concept synapse, highlighting active modulation emphasizing significance function responses conditions injury neurotoxicity. Specifically, it examines roles receptors—such P2X4, P2X7, P2Y1, P2Y12—in mediating key astrocytic microglial phagocytosis, plasticity, neuronal damage. Furthermore, discusses involvement receptors neurological disorders epilepsy, Alzheimer’s disease, Parkinson’s multiple sclerosis, ischemic stroke, Rett syndrome, autism spectrum disorder, well potential therapeutic strategies targeting mitigate inflammation, promote improve clinical outcomes.

Language: Английский

Citations

0
Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy DOI Creative Commons
Péter Illés,

Patrizia Rubini,

Henning Ulrich

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 17, 2025

ABSTRACT The gliotransmitter adenosine 5'‐triphosphate (ATP) and its enzymatic degradation product play a major role in orchestrating the hippocampus cognitive affective functions via P2 purinoceptors (P2X, P2Y) P1 receptors (A1, A2A). Although numerous reviews exist on that modulate these functions, there is an apparent gap relating to involvement of astrocyte‐derived extracellular ATP. Our review focuses following issues: An impeded release ATP from hippocampal astrocytes through vesicular mechanisms or connexin hemichannels pannexin channels interferes with spatial working memory rodents. pharmacological blockade P2Y1 (P2Y1Rs) reverses deficits learning/memory performance mouse models familial Alzheimer's disease (AD). Similarly, depressive disorder (MDD), based acute chronic stress‐induced development depressive‐like behavior, reduced exocytotic/channel‐mediated results deterioration behavioral responses. However, opposite, increased stimulation microglial/astrocytic P2X7R‐channel by causes neuroinflammation consequence behavior. In conclusion, strong evidence for assumption intimately involved pathophysiology neuron/astrocyte‐based human illnesses opening new diagnostic therapeutic vistas AD MDD.

Language: Английский

Citations

0
Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders DOI Creative Commons

Ángel R. Rábago-Monzón,

Juan Fidel Osuna‐Ramos,

David A. Armienta-Rojas

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1121 - 1121

Published: May 6, 2025

Stress and sleep share a reciprocal relationship, where chronic stress often leads to disturbances that worsen neurodegenerative psychiatric conditions. Non-neuronal cells, particularly astrocytes microglia, play critical roles in the brain’s response regulation of sleep. Astrocytes influence architecture by regulating adenosine signaling glymphatic clearance, both which can be disrupted stress, leading reduced restorative Microglia, activated under conditions, drive neuroinflammatory processes further impair exacerbate brain dysfunction. Additionally, gut–brain axis mediates interactions between sleep, inflammation, with microbial metabolites influencing neural pathways. Many these effects converge on disruption synaptic processes, such as neurotransmitter balance, plasticity, pruning, turn contribute pathophysiology disorders. This review explores how cellular systemic mechanisms stress-induced their implications for disorders, offering insights into potential therapeutic strategies targeting non-neuronal cells axis.

Language: Английский

Citations

0
Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila DOI Creative Commons
Jean‐François De Backer,

Thomas Karges,

Julia Papst

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(6), P. 115765 - 115765

Published: May 28, 2025

Language: Английский

Citations

0
Cortical norepinephrine-astrocyte signaling critically mediates learned behavior DOI Creative Commons
Gabrielle T. Drummond,

Arundhati Natesan,

Marco Celotto

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Updating behavior based on feedback from the environment is a crucial means by which organisms learn and develop optimal behavioral strategies

Language: Английский

Citations

2